Murcko scaffold
Ring system with 2 rings and 20 atoms
359 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 20
- Chemicals
- 359
- With full pages
- 8
Scaffold SMILES
O=C(COc1ccccc1)NC(=S)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 359 chemicals
2-Phenoxy-N-(m-tolylcarbamothioyl)acetamide
CAS 299950-80-4C16H16N2O2S
![N-(2-Hydroxy-5-methylphenyl)-N'-[(4-methoxyphenoxy)acetyl]thiourea chemical structure, C17H18N2O4S, CAS 364740-33-0](/s/YNNWHCLTTVMREO-UHFFFAOYSA-N.svg)
N-(2-Hydroxy-5-methylphenyl)-N'-[(4-methoxyphenoxy)acetyl]thiourea
CAS 364740-33-0C17H18N2O4S
N-(2,5-Dimethoxyphenyl)-N'-(phenoxyacetyl)thiourea
CAS 501105-62-0C17H18N2O4S
![2-(2-Chlorophenoxy)-N-[(3,4-dimethylphenyl)carbamothioyl]acetamide chemical structure, C17H17ClN2O2S, CAS 642993-15-5](/s/KYFMPRGICDTONW-UHFFFAOYSA-N.svg)
2-(2-Chlorophenoxy)-N-[(3,4-dimethylphenyl)carbamothioyl]acetamide
CAS 642993-15-5C17H17ClN2O2S
![N-[(3-Nitrophenyl)carbamothioyl]-2-phenoxyacetamide chemical structure, C15H13N3O4S, CAS 501105-68-6](/s/FFJXNBUWSZVOJO-UHFFFAOYSA-N.svg)
N-[(3-Nitrophenyl)carbamothioyl]-2-phenoxyacetamide
CAS 501105-68-6C15H13N3O4S
![N-[[3-(Hydroxymethyl)phenyl]carbamothioyl]-2-(4-methoxyphenoxy)acetamide chemical structure, C17H18N2O4S, CAS 649565-86-6](/s/UZROFFPSHRTOKX-UHFFFAOYSA-N.svg)
N-[[3-(Hydroxymethyl)phenyl]carbamothioyl]-2-(4-methoxyphenoxy)acetamide
CAS 649565-86-6C17H18N2O4S
![N-[(2-Methylphenoxy)acetyl]-N'-(2-methylphenyl)thiourea chemical structure, C17H18N2O2S, CAS 433329-90-9](/s/QBPKKERRYSXKLT-UHFFFAOYSA-N.svg)
N-[(2-Methylphenoxy)acetyl]-N'-(2-methylphenyl)thiourea
CAS 433329-90-9C17H18N2O2S
![N-[(2-Fluorophenyl)carbamothioyl]-2-(2-methylphenoxy)acetamide chemical structure, C16H15FN2O2S, CAS 433703-64-1](/s/YSMMEBPXFKEKIV-UHFFFAOYSA-N.svg)
N-[(2-Fluorophenyl)carbamothioyl]-2-(2-methylphenoxy)acetamide
CAS 433703-64-1C16H15FN2O2S
![N-[(2-Hydroxy-3,5-dimethylphenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide chemical structure, C18H20N2O3S, CAS 445412-58-8](/s/BJJFQTVUSUESOO-UHFFFAOYSA-N.svg)
N-[(2-Hydroxy-3,5-dimethylphenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide
CAS 445412-58-8C18H20N2O3S
![N-[(2,6-Dimethylphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide chemical structure, C18H20N2O2S, CAS 378780-52-0](/s/PPKFKRLQCYLQBK-UHFFFAOYSA-N.svg)
N-[(2,6-Dimethylphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide
CAS 378780-52-0C18H20N2O2S
![N-[(3-Acetylphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide chemical structure, C18H18N2O3S, CAS 380595-89-1](/s/LJAUQBYMVFDWPP-UHFFFAOYSA-N.svg)
N-[(3-Acetylphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide
CAS 380595-89-1C18H18N2O3S
![N-[(2-Methoxyphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide chemical structure, C17H18N2O3S, CAS 378774-53-9](/s/PQPCGXZMPIOQIC-UHFFFAOYSA-N.svg)
N-[(2-Methoxyphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide
CAS 378774-53-9C17H18N2O3S
![N-[(2-Chlorophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide chemical structure, C16H15ClN2O2S, CAS 425655-40-9](/s/JPKWCMRRKMXLSI-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide
CAS 425655-40-9C16H15ClN2O2S
![N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide chemical structure, C17H18N2O3S, CAS 428856-72-8](/s/MNKQVJDUDHAKNE-UHFFFAOYSA-N.svg)
N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide
CAS 428856-72-8C17H18N2O3S
![N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]-2-phenoxyacetamide chemical structure, C16H16N2O3S, CAS 364602-48-2](/s/LYTUSUQLOMBHOZ-UHFFFAOYSA-N.svg)
N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]-2-phenoxyacetamide
CAS 364602-48-2C16H16N2O3S
![N-[(2-Hydroxyphenyl)carbamothioyl]-2-(4-methoxyphenoxy)acetamide chemical structure, C16H16N2O4S, CAS 429655-83-4](/s/NHDSMRDFJQAPFY-UHFFFAOYSA-N.svg)
N-[(2-Hydroxyphenyl)carbamothioyl]-2-(4-methoxyphenoxy)acetamide
CAS 429655-83-4C16H16N2O4S
![Methyl 2-{[(phenoxyacetyl)carbamothioyl]amino}benzoate chemical structure, C17H16N2O4S, CAS 364622-07-1](/s/ZOHVMJGXQWYAJY-UHFFFAOYSA-N.svg)
Methyl 2-{[(phenoxyacetyl)carbamothioyl]amino}benzoate
CAS 364622-07-1C17H16N2O4S
![2-(3,4-Dimethylphenoxy)-N-[(3-fluorophenyl)carbamothioyl]acetamide chemical structure, C17H17FN2O2S, CAS 532949-60-3](/s/XARPIBRRKPCYKI-UHFFFAOYSA-N.svg)
2-(3,4-Dimethylphenoxy)-N-[(3-fluorophenyl)carbamothioyl]acetamide
CAS 532949-60-3C17H17FN2O2S
![N-[(2-Cyanophenyl)thiocarbamoyl]-2-(2,5-dimethylphenoxy)acetamide chemical structure, C18H17N3O2S, CAS 6977-65-7](/s/MRWWKHOTYUYUJD-UHFFFAOYSA-N.svg)
N-[(2-Cyanophenyl)thiocarbamoyl]-2-(2,5-dimethylphenoxy)acetamide
CAS 6977-65-7C18H17N3O2S
![2-(2,5-Dimethylphenoxy)-N-[(4-methylphenyl)carbamothioyl]acetamide chemical structure, C18H20N2O2S, CAS 6977-63-5](/s/ZVXOZQAXSJYSML-UHFFFAOYSA-N.svg)
2-(2,5-Dimethylphenoxy)-N-[(4-methylphenyl)carbamothioyl]acetamide
CAS 6977-63-5C18H20N2O2S
2-(4-Nitrophenoxy)-N-(phenylcarbamothioyl)acetamide
CAS 83277-10-5C15H13N3O4S
![N-[(2-Cyanophenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide chemical structure, C18H17N3O2S, CAS 6978-25-2](/s/HGPNWLMRMGHTFP-UHFFFAOYSA-N.svg)
N-[(2-Cyanophenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide
CAS 6978-25-2C18H17N3O2S
![2-(2-Chlorophenoxy)-N-[(4-methylphenyl)carbamothioyl]acetamide chemical structure, C16H15ClN2O2S, CAS 6978-32-1](/s/KUBXTPRBUOJASH-UHFFFAOYSA-N.svg)
2-(2-Chlorophenoxy)-N-[(4-methylphenyl)carbamothioyl]acetamide
CAS 6978-32-1C16H15ClN2O2S
![2-(2-Chlorophenoxy)-N-[(4-fluorophenyl)carbamothioyl]acetamide chemical structure, C15H12ClFN2O2S, CAS 6978-33-2](/s/AFGQAJNGVHIJMN-UHFFFAOYSA-N.svg)
2-(2-Chlorophenoxy)-N-[(4-fluorophenyl)carbamothioyl]acetamide
CAS 6978-33-2C15H12ClFN2O2S
- 2-Methyl-3-[(2-phenoxyacetyl)carbamothioylamino]benzoic acid532388-44-6C17H16N2O4S
- Benzoic acid, 4-[[[[(3-methylphenoxy)acetyl]amino]thioxomethyl]amino]-87998-78-5C17H16N2O4S
- Benzoic acid, 4-[[[[(2-methylphenoxy)acetyl]amino]thioxomethyl]amino]-87998-77-4C17H16N2O4S
- N-[(4-Bromophenyl)carbamothioyl]-2-phenoxyacetamide312616-56-1C15H13BrN2O2S
- 2-Phenoxy-N-[(2,4,5-trichlorophenyl)carbamothioyl]acetamide429642-01-3C15H11Cl3N2O2S
- 2-(4-Bromophenoxy)-N-[(2,5-dimethoxyphenyl)carbamothioyl]acetamide642978-91-4C17H17BrN2O4S
- N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-(4-methoxyphenoxy)acetamide649565-69-5C18H20N2O5S
- N-[(3-Acetylphenyl)carbamothioyl]-2-(4-bromo-3-methylphenoxy)acetamide642980-62-9C18H17BrN2O3S
- N-[(4-Acetylphenyl)carbamothioyl]-2-(2,5-dimethylphenoxy)acetamide642983-97-9C19H20N2O3S
- 2-[[2-(4-Bromo-2-methylphenoxy)acetyl]carbamothioylamino]benzamide642985-49-7C17H16BrN3O3S
- N-[[4-(Diethylsulfamoyl)phenyl]carbamothioyl]-2-phenoxyacetamide501105-43-7C19H23N3O4S2
- N-[(3,4-Dichlorophenyl)carbamothioyl]-2-(2-methoxyphenoxy)acetamide642973-94-2C16H14Cl2N2O3S
- 2-(4-Bromo-2-chlorophenoxy)-N-[(3-methoxyphenyl)carbamothioyl]acetamide587841-74-5C16H14BrClN2O3S
- N-[(2,4-Dichlorophenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide658069-64-8C16H14Cl2N2O2S
- 2-(4-Bromophenoxy)-N-[(2,5-dichlorophenyl)carbamothioyl]acetamide433245-02-4C15H11BrCl2N2O2S
- N-(4-Acetylphenyl)-N'-[(4-bromophenoxy)acetyl]thiourea432514-81-3C17H15BrN2O3S
- 2-(3,4-Dimethylphenoxy)-N-[[3-(trifluoromethyl)phenyl]carbamothioyl]acetamide445412-47-5C18H17F3N2O2S
- 2-(2,4-Dimethylphenoxy)-N-[(2,4,5-trichlorophenyl)carbamothioyl]acetamide433329-71-6C17H15Cl3N2O2S
- 2-(4-Bromophenoxy)-N-[(4-chloro-2,5-dimethoxyphenyl)carbamothioyl]acetamide364615-26-9C17H16BrClN2O4S
- 2-(4-Bromophenoxy)-N-[(2-propan-2-ylphenyl)carbamothioyl]acetamide433699-00-4C18H19BrN2O2S
- N-[(4-Chloro-2,5-dimethoxyphenyl)carbamothioyl]-2-(4-propan-2-ylphenoxy)acetamide639057-71-9C20H23ClN2O4S
- 2-(2,4-Dichlorophenoxy)-N-[(2-iodophenyl)carbamothioyl]acetamide445418-69-9C15H11Cl2IN2O2S
- N-[(3-Bromophenyl)carbamothioyl]-2-(2,4-dichlorophenoxy)acetamide445419-12-5C15H11BrCl2N2O2S
- N-[(4-Bromo-3-methylphenyl)carbamothioyl]-2-(3,4-dimethylphenoxy)acetamide445419-39-6C18H19BrN2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1251 chemicals
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals
O=C(NCCc1ccccc1)OCc1ccccc142 chemicals
O=C(CCc1ccccc1)NCCc1ccccc138 chemicals
c1ccc(CCCNCCc2ccccc2)cc138 chemicals
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals
c1ccc(CCNCCOc2ccccc2)cc126 chemicals
O=C(CCCOc1ccccc1)Nc1ccccc121 chemicals
O=C(COc1ccccc1)NCCc1ccccc120 chemicals