Murcko scaffold
Ring system with 2 rings and 20 atoms
359 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 20
- Chemicals
- 359
- With full pages
- 8
Scaffold SMILES
O=C(COc1ccccc1)NC(=S)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 96 of 359 chemicals
![N-[(5-Chloro-2-methoxyphenyl)carbamothioyl]-2-(4-chlorophenoxy)acetamide chemical structure, C16H14Cl2N2O3S, CAS 445419-53-4](/s/QKFFOJWWGJPFBB-UHFFFAOYSA-N.svg)
N-[(5-Chloro-2-methoxyphenyl)carbamothioyl]-2-(4-chlorophenoxy)acetamide
CAS 445419-53-4C16H14Cl2N2O3S
![N-[(3-Chloro-4-methylphenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide chemical structure, C18H19ClN2O2S, CAS 445419-63-6](/s/SRXYWXQEISZUME-UHFFFAOYSA-N.svg)
N-[(3-Chloro-4-methylphenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide
CAS 445419-63-6C18H19ClN2O2S
![N-[(2-Chloro-4-iodophenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide chemical structure, C17H16ClIN2O2S, CAS 445420-30-4](/s/UMEBOBIOAWJFHU-UHFFFAOYSA-N.svg)
N-[(2-Chloro-4-iodophenyl)carbamothioyl]-2-(4-ethylphenoxy)acetamide
CAS 445420-30-4C17H16ClIN2O2S
![2-(2,4-Dichlorophenoxy)-N-[(4-iodo-2-methylphenyl)carbamothioyl]acetamide chemical structure, C16H13Cl2IN2O2S, CAS 431941-34-3](/s/PYVMZYPDUNVMPB-UHFFFAOYSA-N.svg)
2-(2,4-Dichlorophenoxy)-N-[(4-iodo-2-methylphenyl)carbamothioyl]acetamide
CAS 431941-34-3C16H13Cl2IN2O2S
![Methyl 2-[({[(4-isopropylphenoxy)acetyl]amino}carbonothioyl)amino]benzoate chemical structure, C20H22N2O4S, CAS 639057-68-4](/s/ATXLEIAXWKNTPE-UHFFFAOYSA-N.svg)
Methyl 2-[({[(4-isopropylphenoxy)acetyl]amino}carbonothioyl)amino]benzoate
CAS 639057-68-4C20H22N2O4S
![N-[(4-Bromo-2,6-dimethylphenyl)carbamothioyl]-2-(4-propan-2-ylphenoxy)acetamide chemical structure, C20H23BrN2O2S, CAS 639057-75-3](/s/FMGZZQDAXLZTFE-UHFFFAOYSA-N.svg)
N-[(4-Bromo-2,6-dimethylphenyl)carbamothioyl]-2-(4-propan-2-ylphenoxy)acetamide
CAS 639057-75-3C20H23BrN2O2S
![Dimethyl 5-[[2-(2,4-dichlorophenoxy)acetyl]carbamothioylamino]benzene-1,3-dicarboxylate chemical structure, C19H16Cl2N2O6S, CAS 445420-56-4](/s/HZBFOLFCXLIZQM-UHFFFAOYSA-N.svg)
Dimethyl 5-[[2-(2,4-dichlorophenoxy)acetyl]carbamothioylamino]benzene-1,3-dicarboxylate
CAS 445420-56-4C19H16Cl2N2O6S
![N-[(2-Fluoro-4-iodophenyl)carbamothioyl]-2-phenoxyacetamide chemical structure, C15H12FIN2O2S, CAS 835894-07-0](/s/DRLCWNMPMXGUCY-UHFFFAOYSA-N.svg)
N-[(2-Fluoro-4-iodophenyl)carbamothioyl]-2-phenoxyacetamide
CAS 835894-07-0C15H12FIN2O2S
![N-[[2-(Difluoromethoxy)phenyl]carbamothioyl]-2-phenoxyacetamide chemical structure, C16H14F2N2O3S, CAS 674817-66-4](/s/AZNOJWBYMVPDPQ-UHFFFAOYSA-N.svg)
N-[[2-(Difluoromethoxy)phenyl]carbamothioyl]-2-phenoxyacetamide
CAS 674817-66-4C16H14F2N2O3S
![2-(4-Bromophenoxy)-N-[(3-chloro-2-methylphenyl)carbamothioyl]acetamide chemical structure, C16H14BrClN2O2S, CAS 642978-87-8](/s/WAAXMURPKDPQPS-UHFFFAOYSA-N.svg)
2-(4-Bromophenoxy)-N-[(3-chloro-2-methylphenyl)carbamothioyl]acetamide
CAS 642978-87-8C16H14BrClN2O2S
![4-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)benzoic acid chemical structure, C16H13ClN2O4S, CAS 87998-80-9](/s/QJNWIFXGEHEWPT-UHFFFAOYSA-N.svg)
4-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)benzoic acid
CAS 87998-80-9C16H13ClN2O4S
![2-(2,5-Dimethylphenoxy)-N-[(2,4,5-trichlorophenyl)carbamothioyl]acetamide chemical structure, C17H15Cl3N2O2S, CAS 642985-05-5](/s/XYWGMOGESJVGAP-UHFFFAOYSA-N.svg)
2-(2,5-Dimethylphenoxy)-N-[(2,4,5-trichlorophenyl)carbamothioyl]acetamide
CAS 642985-05-5C17H15Cl3N2O2S
![2-(2-Bromo-4-ethylphenoxy)-N-[(3-chlorophenyl)carbamothioyl]acetamide chemical structure, C17H16BrClN2O2S, CAS 649563-48-4](/s/LXCDMIYLRVDQAX-UHFFFAOYSA-N.svg)
2-(2-Bromo-4-ethylphenoxy)-N-[(3-chlorophenyl)carbamothioyl]acetamide
CAS 649563-48-4C17H16BrClN2O2S
![3-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)-2-methylbenzoic acid chemical structure, C17H15ClN2O4S, CAS 535939-27-6](/s/VEQOKIBNWJMOSV-UHFFFAOYSA-N.svg)
3-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)-2-methylbenzoic acid
CAS 535939-27-6C17H15ClN2O4S
![2-(4-Bromo-2-chlorophenoxy)-N-[(2-methoxy-5-nitrophenyl)carbamothioyl]acetamide chemical structure, C16H13BrClN3O5S, CAS 649564-80-7](/s/HJCSTHDFUVUOET-UHFFFAOYSA-N.svg)
2-(4-Bromo-2-chlorophenoxy)-N-[(2-methoxy-5-nitrophenyl)carbamothioyl]acetamide
CAS 649564-80-7C16H13BrClN3O5S
![2-(4-Bromophenoxy)-N-[(3-nitrophenyl)carbamothioyl]acetamide chemical structure, C15H12BrN3O4S, CAS 642978-33-4](/s/PGUKADDZYNZJPB-UHFFFAOYSA-N.svg)
2-(4-Bromophenoxy)-N-[(3-nitrophenyl)carbamothioyl]acetamide
CAS 642978-33-4C15H12BrN3O4S
![4-({[(3,5-Dimethylphenoxy)acetyl]carbamothioyl}amino)benzoic acid chemical structure, C18H18N2O4S, CAS 532979-46-7](/s/FPJOVUQOSACWAE-UHFFFAOYSA-N.svg)
4-({[(3,5-Dimethylphenoxy)acetyl]carbamothioyl}amino)benzoic acid
CAS 532979-46-7C18H18N2O4S
![3-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)benzoic acid chemical structure, C16H13ClN2O4S, CAS 532978-57-7](/s/GFFMDHDMMYMVHV-UHFFFAOYSA-N.svg)
3-({[(2-Chlorophenoxy)acetyl]carbamothioyl}amino)benzoic acid
CAS 532978-57-7C16H13ClN2O4S
![3-[[[[(4-Bromophenoxy)acetyl]amino]thioxomethyl]amino]-4-chloro-benzoic acid chemical structure, C16H12BrClN2O4S, CAS 535949-06-5](/s/PWFSQNVRAFUPCS-UHFFFAOYSA-N.svg)
3-[[[[(4-Bromophenoxy)acetyl]amino]thioxomethyl]amino]-4-chloro-benzoic acid
CAS 535949-06-5C16H12BrClN2O4S
![N-[3-[[2-(3,4-Dimethylphenoxy)acetyl]carbamothioylamino]phenyl]-2-methylpropanamide chemical structure, C21H25N3O3S, CAS 446250-78-8](/s/IGRQHPDWSGJSKL-UHFFFAOYSA-N.svg)
N-[3-[[2-(3,4-Dimethylphenoxy)acetyl]carbamothioylamino]phenyl]-2-methylpropanamide
CAS 446250-78-8C21H25N3O3S
![3-({[(3,4-Dimethylphenoxy)acetyl]carbamothioyl}amino)-4-methylbenzoic acid chemical structure, C19H20N2O4S, CAS 462096-83-9](/s/DYECWJSLQRBTQZ-UHFFFAOYSA-N.svg)
3-({[(3,4-Dimethylphenoxy)acetyl]carbamothioyl}amino)-4-methylbenzoic acid
CAS 462096-83-9C19H20N2O4S
![4-Methyl-3-[({[4-(propan-2-yl)phenoxy]acetyl}carbamothioyl)amino]benzoic acid chemical structure, C20H22N2O4S, CAS 462604-88-2](/s/AHYSXTMXIJVAMF-UHFFFAOYSA-N.svg)
4-Methyl-3-[({[4-(propan-2-yl)phenoxy]acetyl}carbamothioyl)amino]benzoic acid
CAS 462604-88-2C20H22N2O4S
![2-[[2-(2,4-Dichlorophenoxy)acetyl]carbamothioylamino]benzoic acid chemical structure, C16H12Cl2N2O4S, CAS 157921-81-8](/s/VPQLHFWULQZRNE-UHFFFAOYSA-N.svg)
2-[[2-(2,4-Dichlorophenoxy)acetyl]carbamothioylamino]benzoic acid
CAS 157921-81-8C16H12Cl2N2O4S
![4-[[2-(3,4-Dimethylphenoxy)acetyl]carbamothioylamino]benzoic acid chemical structure, C18H18N2O4S, CAS 532957-21-4](/s/UQWLUEIFFAEANO-UHFFFAOYSA-N.svg)
4-[[2-(3,4-Dimethylphenoxy)acetyl]carbamothioylamino]benzoic acid
CAS 532957-21-4C18H18N2O4S
- 2-Methyl-3-({[(3-methylphenoxy)acetyl]carbamothioyl}amino)benzoic acid434306-61-3C18H18N2O4S
- 3-({[(4-Chlorophenoxy)acetyl]carbamothioyl}amino)-2-methylbenzoic acid434308-44-8C17H15ClN2O4S
- 3-({[(4-Ethylphenoxy)acetyl]carbamothioyl}amino)-4-methoxybenzoic acid434310-08-4C19H20N2O5S
- 4-[[[[(4-Bromophenoxy)acetyl]amino]thioxomethyl]amino]-benzoic acid532429-75-7C16H13BrN2O4S
- 3-({[(4-Bromophenoxy)acetyl]carbamothioyl}amino)-4-methoxybenzoic acid690651-57-1C17H15BrN2O5S
- 3-[[[[(4-Bromophenoxy)acetyl]amino]thioxomethyl]amino]-2-methyl-benzoic acid532420-71-6C17H15BrN2O4S
- N-[(2-Fluoro-5-nitrophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide425658-34-0C16H14FN3O4S
- N-[(4-Bromophenyl)carbamothioyl]-2-(3-methylphenoxy)acetamide425659-47-8C16H15BrN2O2S
- N-[(4-Chloro-3-nitrophenyl)carbamothioyl]-2-phenoxyacetamide429641-22-5C15H12ClN3O4S
- N-[(3,4-Dichlorophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide380595-42-6C16H14Cl2N2O2S
- N-[(4-Bromo-2,6-dimethylphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide380887-89-8C18H19BrN2O2S
- Methyl 2-({[(4-methylphenoxy)acetyl]carbamothioyl}amino)benzoate425660-80-6C18H18N2O4S
- N-[(2,4-Dichlorophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide378754-42-8C16H14Cl2N2O2S
- N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide381694-32-2C18H20N2O4S
- N-[(4-Acetamidophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide380877-80-5C18H19N3O3S
- N-[(5-tert-Butyl-2-hydroxyphenyl)carbamothioyl]-2-(2-chloro-4-methylphenoxy)acetamide428856-25-1C20H23ClN2O3S
- 2-(2,4-Dichlorophenoxy)-N-[(3,5-dimethylphenyl)carbamothioyl]acetamide380310-79-2C17H16Cl2N2O2S
- 2-(4-Bromophenoxy)-N-[(2-hydroxy-5-methylanilino)-sulfanylidenemethyl]acetamide430445-86-6C16H15BrN2O3S
- N-[[2-Chloro-5-(trifluoromethyl)phenyl]carbamothioyl]-2-(4-methylphenoxy)acetamide380553-33-3C17H14ClF3N2O2S
- 2-(4-Methylphenoxy)-N-[[2-(trifluoromethyl)phenyl]carbamothioyl]acetamide380585-43-3C17H15F3N2O2S
- 2-(4-tert-Butylphenoxy)-N-[(4-fluoro-3-nitrophenyl)carbamothioyl]acetamide425652-34-2C19H20FN3O4S
- 2-(4-tert-Butylphenoxy)-N-[[2-(trifluoromethyl)phenyl]carbamothioyl]acetamide425655-78-3C20H21F3N2O2S
- N-[(4-Bromo-2-fluorophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide380901-90-6C16H14BrFN2O2S
- N-[(4-Chloro-3-nitrophenyl)carbamothioyl]-2-(4-methylphenoxy)acetamide4362-39-4C16H14ClN3O4S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)NN=Cc1ccccc1255 chemicals
O=C(NN=Cc1ccccc1)C(=O)Nc1ccccc1251 chemicals
O=C(NCNC(=S)Nc1ccccc1)c1ccccc179 chemicals
O=C(C=Cc1ccccc1)NCCc1ccccc145 chemicals
O=C(NCCc1ccccc1)OCc1ccccc142 chemicals
O=C(CCc1ccccc1)NCCc1ccccc138 chemicals
c1ccc(CCCNCCc2ccccc2)cc138 chemicals
O=C(CNc1ccccc1)NN=Cc1ccccc126 chemicals
O=S(=O)(NC=NCCc1ccccc1)c1ccccc126 chemicals
c1ccc(CCNCCOc2ccccc2)cc126 chemicals
O=C(CCCOc1ccccc1)Nc1ccccc121 chemicals
O=C(COc1ccccc1)NCCc1ccccc120 chemicals