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Murcko scaffold

1,4-Dioxaspiro[4.5]decan-8-one scaffold

36 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
36
With full pages
5
Scaffold SMILES

O=C1CCC2(CC1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxaspiro[4.5]decan-8-one page
Murcko scaffold O=C1CCC2(CC1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

7-Methyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C9H14O3, CAS 702-69-2
7-Methyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 702-69-2C9H14O3
7-(2-Oxopropyl)-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C11H16O4, CAS 903634-18-4
7-(2-Oxopropyl)-1,4-dioxaspiro[4.5]decan-8-one
CAS 903634-18-4C11H16O4
Ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate chemical structure, C11H16O5, CAS 14160-65-7
Ethyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
CAS 14160-65-7C11H16O5
1,4-Dioxaspiro[4.5]decan-8-one chemical structure, C8H12O3, CAS 4746-97-8
1,4-Dioxaspiro[4.5]decan-8-one
CAS 4746-97-8C8H12O3
Methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate chemical structure, C10H14O5, CAS 52506-21-5
Methyl 8-oxo-1,4-dioxaspiro[4.5]decane-7-carboxylate
CAS 52506-21-5C10H14O5
6-Methyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C9H14O3, CAS 128563-89-3
6-Methyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 128563-89-3C9H14O3
Ethyl 2-{8-oxo-1,4-dioxaspiro[4.5]decan-7-yl}acetate chemical structure, C12H18O5, CAS 1027377-64-5
Ethyl 2-{8-oxo-1,4-dioxaspiro[4.5]decan-7-yl}acetate
CAS 1027377-64-5C12H18O5
1,4-Cyclohexanedione monoethylene acetal-d4 chemical structure, C8H12O3, CAS 56292-88-7
1,4-Cyclohexanedione monoethylene acetal-d4
CAS 56292-88-7C8H12O3
7-Hydroxy-7,9,9-trimethyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C11H18O4, CAS 99708-51-7
7-Hydroxy-7,9,9-trimethyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 99708-51-7C11H18O4
7,9,9-Trimethyl-8-oxo-1,4-dioxaspiro[4.5]decan-7-yl (diethoxyphosphoryl)acetate chemical structure, C17H29O8P, CAS 162188-93-4
7,9,9-Trimethyl-8-oxo-1,4-dioxaspiro[4.5]decan-7-yl (diethoxyphosphoryl)acetate
CAS 162188-93-4C17H29O8P
7,9,9-Trimethyl-8-oxo-1,4-dioxaspiro[4.5]decan-7-yl bromoacetate chemical structure, C13H19BrO5, CAS 162188-92-3
7,9,9-Trimethyl-8-oxo-1,4-dioxaspiro[4.5]decan-7-yl bromoacetate
CAS 162188-92-3C13H19BrO5
7,7-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C10H16O3, CAS 134409-06-6
7,7-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 134409-06-6C10H16O3
Ethyl 5,5-ethylenedioxy-1-methyl-2-oxocyclohexanecarboxylate chemical structure, C12H18O5, CAS 92115-18-9
Ethyl 5,5-ethylenedioxy-1-methyl-2-oxocyclohexanecarboxylate
CAS 92115-18-9C12H18O5
7-(Prop-2-yn-1-yl)-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C11H14O3, CAS 93351-57-6
7-(Prop-2-yn-1-yl)-1,4-dioxaspiro[4.5]decan-8-one
CAS 93351-57-6C11H14O3
6,7-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C10H16O3, CAS 81040-62-2
6,7-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 81040-62-2C10H16O3
7,7,9,9-Tetramethyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C12H20O3, CAS 561307-28-6
7,7,9,9-Tetramethyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 561307-28-6C12H20O3
7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C8H12O4, CAS 1822648-68-9
7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one
CAS 1822648-68-9C8H12O4
8-Oxo-1,4-dioxaspiro[4.5]decane-7-carbaldehyde chemical structure, C9H12O4, CAS 155261-05-5
8-Oxo-1,4-dioxaspiro[4.5]decane-7-carbaldehyde
CAS 155261-05-5C9H12O4
7-Chloro-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C8H11ClO3, CAS 815575-85-0
7-Chloro-1,4-dioxaspiro[4.5]decan-8-one
CAS 815575-85-0C8H11ClO3
(R)-7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C8H12O4, CAS 851764-31-3
(R)-7-Hydroxy-1,4-dioxaspiro[4.5]decan-8-one
CAS 851764-31-3C8H12O4
7-Acetyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C10H14O4, CAS 2137992-23-3
7-Acetyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 2137992-23-3C10H14O4
6,6-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C10H16O3, CAS 131206-75-2
6,6-Dimethyl-1,4-dioxaspiro[4.5]decan-8-one
CAS 131206-75-2C10H16O3
7-(2,2,2-Trifluoroacetyl)-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C10H11F3O4, CAS 1092459-44-3
7-(2,2,2-Trifluoroacetyl)-1,4-dioxaspiro[4.5]decan-8-one
CAS 1092459-44-3C10H11F3O4
7-Bromo-1,4-dioxaspiro[4.5]decan-8-one chemical structure, C8H11BrO3, CAS 943589-83-1
7-Bromo-1,4-dioxaspiro[4.5]decan-8-one
CAS 943589-83-1C8H11BrO3