Murcko scaffold
Ring system with 2 rings and 15 atoms
108 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 108
- With full pages
- 10
Scaffold SMILES
O=C(Cn1ccnn1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 108 chemicals
![Ethyl 1-{2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C14H15ClN4O4, CAS 902482-47-7](/s/PFGDFTMHYARDPP-UHFFFAOYSA-N.svg)
Ethyl 1-{2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate
CAS 902482-47-7C14H15ClN4O4
![Ethyl 1-{[(4-ethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C15H18N4O3, CAS 901723-84-0](/s/IFOMLNDYAGRXLZ-UHFFFAOYSA-N.svg)
Ethyl 1-{[(4-ethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate
CAS 901723-84-0C15H18N4O3
![Ethyl 1-[2-oxo-2-(4-propan-2-ylanilino)ethyl]triazole-4-carboxylate chemical structure, C16H20N4O3, CAS 902564-56-1](/s/MMGPXYCIISKSDA-UHFFFAOYSA-N.svg)
Ethyl 1-[2-oxo-2-(4-propan-2-ylanilino)ethyl]triazole-4-carboxylate
CAS 902564-56-1C16H20N4O3
![Ethyl 1-({[2-(ethoxycarbonyl)phenyl]carbamoyl}methyl)-1H-1,2,3-triazole-4-carboxylate chemical structure, C16H18N4O5, CAS 902482-57-9](/s/NDKMBJSOTXTPFB-UHFFFAOYSA-N.svg)
Ethyl 1-({[2-(ethoxycarbonyl)phenyl]carbamoyl}methyl)-1H-1,2,3-triazole-4-carboxylate
CAS 902482-57-9C16H18N4O5
![5-Amino-1-{2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide chemical structure, C13H16N6O4, CAS 901046-40-0](/s/VOUGKYHXXDFZTI-UHFFFAOYSA-N.svg)
5-Amino-1-{2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide
CAS 901046-40-0C13H16N6O4
![Diethyl 1-{2-[(4-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C17H20N4O5, CAS 828273-96-7](/s/JLMLZZCPLJFKRH-UHFFFAOYSA-N.svg)
Diethyl 1-{2-[(4-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 828273-96-7C17H20N4O5
![Ethyl 1-{2-[(4-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C14H16N4O3, CAS 901885-02-7](/s/ZXXFWKZSHLIZBQ-UHFFFAOYSA-N.svg)
Ethyl 1-{2-[(4-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate
CAS 901885-02-7C14H16N4O3
![Methyl 5-amino-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxylate chemical structure, C12H13N5O3, CAS 892291-91-7](/s/VIGVRPXASDCTPU-UHFFFAOYSA-N.svg)
Methyl 5-amino-1-[2-oxo-2-(phenylamino)ethyl]-1H-1,2,3-triazole-4-carboxylate
CAS 892291-91-7C12H13N5O3
![Ethyl 1-[2-(3-methoxyanilino)-2-oxoethyl]triazole-4-carboxylate chemical structure, C14H16N4O4, CAS 901723-88-4](/s/FYVNQLMXUXYLBZ-UHFFFAOYSA-N.svg)
Ethyl 1-[2-(3-methoxyanilino)-2-oxoethyl]triazole-4-carboxylate
CAS 901723-88-4C14H16N4O4
![Dimethyl 1-{2-[(4-chlorophenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C14H13ClN4O5, CAS 124193-36-8](/s/HNVUXKSBDOIQGQ-UHFFFAOYSA-N.svg)
Dimethyl 1-{2-[(4-chlorophenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 124193-36-8C14H13ClN4O5
![Methyl 1-{[(4-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C13H14N4O3, CAS 124193-38-0](/s/JCSSYAPEPSLSHY-UHFFFAOYSA-N.svg)
Methyl 1-{[(4-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate
CAS 124193-38-0C13H14N4O3
![Methyl 1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C13H14N4O3, CAS 124844-80-0](/s/QJNGMCWKPGDFNP-UHFFFAOYSA-N.svg)
Methyl 1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate
CAS 124844-80-0C13H14N4O3
![Methyl 1-{[(2-chlorophenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C12H11ClN4O3, CAS 124193-39-1](/s/IZFKILLTUFRTBB-UHFFFAOYSA-N.svg)
Methyl 1-{[(2-chlorophenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate
CAS 124193-39-1C12H11ClN4O3
![Methyl 1-{[(4-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C13H14N4O4, CAS 124193-40-4](/s/USYPMRAZFWVCPM-UHFFFAOYSA-N.svg)
Methyl 1-{[(4-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate
CAS 124193-40-4C13H14N4O4
![Diethyl 1-(1-{[(2,6-dimethylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C20H26N4O5, CAS 865656-91-3](/s/CIPMLNDAMIIOEQ-UHFFFAOYSA-N.svg)
Diethyl 1-(1-{[(2,6-dimethylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 865656-91-3C20H26N4O5
![Ethyl 1-{2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate chemical structure, C15H18N4O5, CAS 902564-68-5](/s/ACUSRCHVQCXEIJ-UHFFFAOYSA-N.svg)
Ethyl 1-{2-[(2,4-dimethoxyphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate
CAS 902564-68-5C15H18N4O5
![4,5-Diethyl 1-{[(3-bromophenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C16H17BrN4O5, CAS 912791-29-8](/s/XVKANLMVZDRSMM-UHFFFAOYSA-N.svg)
4,5-Diethyl 1-{[(3-bromophenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 912791-29-8C16H17BrN4O5
![Dimethyl 1-{1-[(2-fluorophenyl)amino]-1-oxobutan-2-yl}-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C16H17FN4O5, CAS 865656-88-8](/s/XMTUGJQPBATHNV-UHFFFAOYSA-N.svg)
Dimethyl 1-{1-[(2-fluorophenyl)amino]-1-oxobutan-2-yl}-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 865656-88-8C16H17FN4O5
![Diethyl 1-(1-{[(5-chloro-2-methylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C19H23ClN4O5, CAS 865656-89-9](/s/BFBYVUAUTHMSRN-UHFFFAOYSA-N.svg)
Diethyl 1-(1-{[(5-chloro-2-methylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 865656-89-9C19H23ClN4O5
![Diethyl 1-(1-{[(2,5-dimethylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C20H26N4O5, CAS 865656-90-2](/s/XPKNYLSJYLYNDD-UHFFFAOYSA-N.svg)
Diethyl 1-(1-{[(2,5-dimethylphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 865656-90-2C20H26N4O5
![Diethyl 1-(1-{[(4-methoxyphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate chemical structure, C19H24N4O6, CAS 865656-92-4](/s/BSOZRKPQICGUOH-UHFFFAOYSA-N.svg)
Diethyl 1-(1-{[(4-methoxyphenyl)amino]carbonyl}propyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 865656-92-4C19H24N4O6
Diethyl 1-(2-((3-chloro-4-fluorophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 912781-28-3C16H16ClFN4O5
Diethyl 1-(2-((4-bromo-2-fluorophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 912781-31-8C16H16BrFN4O5
Diethyl 1-(2-((4-(methoxycarbonyl)phenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate
CAS 912773-97-8C18H20N4O7
- Dimethyl 1-(2-((4-(methoxycarbonyl)phenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate912791-34-5C16H16N4O7
- Dimethyl 1-(2-((4-bromo-2-fluorophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate912781-35-2C14H12BrFN4O5
- Ethyl 1-{[(2-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate901723-78-2C14H16N4O3
- Ethyl 1-{[(3-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate902482-27-3C14H16N4O3
- Ethyl 1-{2-[(4-fluorophenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate902482-31-9C13H13FN4O3
- Ethyl 1-{2-[(3-chloro-4-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate902482-39-7C14H15ClN4O3
- Ethyl 1-({[2-(trifluoromethyl)phenyl]carbamoyl}methyl)-1H-1,2,3-triazole-4-carboxylate901723-86-2C14H13F3N4O3
- Ethyl 1-{[(4-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate902564-64-1C14H16N4O4
- Ethyl 1-{[(4-ethoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate901885-08-3C15H18N4O4
- Ethyl 1-{2-[(3,4-dimethylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate901723-92-0C15H18N4O3
- Ethyl 1-{[(2,4-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate902482-52-4C15H18N4O3
- Ethyl 1-{[(2,5-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate902564-72-1C15H18N4O3
- Ethyl 1-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate901885-12-9C15H18N4O3
- Ethyl 1-{2-[(2,6-dimethylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylate901723-93-1C15H18N4O3
- 2-[4-(Aminomethyl)-1H-1,2,3-triazol-1-yl]-N-phenylacetamide1239943-29-3C11H13N5O
- Methyl 1-{[(3,4,5-trimethoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate1371019-04-3C15H18N4O6
- Methyl 1-{[(3-methoxyphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate1371773-35-1C13H14N4O4
- Methyl 1-{[(3-chloro-4-methylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate1355811-81-2C13H13ClN4O3
- Methyl 1-{[(3,5-dimethylphenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate1371044-87-9C14H16N4O3
- 2-[4-(Aminomethyl)-1H-1,2,3-triazol-1-yl]-N-(3,5-difluorophenyl)acetamide1456321-72-4C11H11F2N5O
- 2-[4-(Hydroxymethyl)-1H-1,2,3-triazol-1-yl]-N-phenylacetamide1457737-37-9C11H12N4O2
- 1-{2-[4-(2-Hydroxyethyl)anilino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxylic acid1532692-97-9C13H14N4O4
- 2-[4-(Aminomethyl)-1H-1,2,3-triazol-1-yl]-N-(3,5-dichlorophenyl)acetamide1327151-40-5C11H11Cl2N5O
- Methyl 1-{[methyl(phenyl)carbamoyl]methyl}-1H-1,2,3-triazole-4-carboxylate1920324-30-6C13H14N4O3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(OCc1ccccc1)N1CCCC161 chemicals
O=C(NCc1ccco1)c1ccccc158 chemicals
O=C(Cc1cccs1)Nc1ccccc141 chemicals
O=C(NCC1CCCO1)c1ccccc138 chemicals
O=C(NCC1CCCN1)c1ccccc138 chemicals
O=C(Cc1ccccc1)Nc1nccs137 chemicals
O=S(=O)(NCc1ccco1)c1ccccc136 chemicals
O=S(=O)(NCC1CCCO1)c1ccccc134 chemicals
O=C(NCc1ccccc1)c1ccco130 chemicals
O=C(NCc1ccccc1)c1cccs128 chemicals
c1ccc(CNCc2ccco2)cc128 chemicals![Scaffold O=C(NCc1ccccc1)c1ccc[nH]1](/scaffold/PSYQATYJXPGBDC-UHFFFAOYSA-N/structure.svg)
O=C(NCc1ccccc1)c1ccc[nH]125 chemicals