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Murcko scaffold

Ring system with 3 rings and 22 atoms

266 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
266
With full pages
13
Scaffold SMILES

O=C(c1ccccc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 266 chemicals

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-4-isopropoxybenzamide chemical structure, C20H20FNO4S, CAS 852439-15-7
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-4-isopropoxybenzamide
CAS 852439-15-7C20H20FNO4S
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide chemical structure, C19H18BrNO5S, CAS 863445-65-2
N-(4-Bromophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide
CAS 863445-65-2C19H18BrNO5S
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-(trifluoromethyl)benzamide chemical structure, C20H18F3NO5S, CAS 852439-51-1
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-(trifluoromethyl)benzamide
CAS 852439-51-1C20H18F3NO5S
2-Chloro-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)benzamide chemical structure, C18H16ClNO4S, CAS 852439-20-4
2-Chloro-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)benzamide
CAS 852439-20-4C18H16ClNO4S
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3-methylbenzamide chemical structure, C20H21NO5S, CAS 852439-37-3
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3-methylbenzamide
CAS 852439-37-3C20H21NO5S
4-Chloro-N-(3,4-dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)benzamide chemical structure, C19H18ClNO3S, CAS 326017-13-4
4-Chloro-N-(3,4-dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothien-3-yl)benzamide
CAS 326017-13-4C19H18ClNO3S
N-(3,5-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide chemical structure, C19H19NO3S, CAS 863445-92-5
N-(3,5-Dimethylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide
CAS 863445-92-5C19H19NO3S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-2-methylbenzamide chemical structure, C19H19NO4S, CAS 852439-19-1
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-2-methylbenzamide
CAS 852439-19-1C19H19NO4S
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide chemical structure, C21H23NO7S, CAS 863443-79-2
N-(2,4-Dimethoxyphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide
CAS 863443-79-2C21H23NO7S
4-Butoxy-N-(4-chlorophenyl)-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)benzamide chemical structure, C21H22ClNO4S, CAS 852438-18-7
4-Butoxy-N-(4-chlorophenyl)-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)benzamide
CAS 852438-18-7C21H22ClNO4S
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-fluorobenzamide chemical structure, C17H13ClFNO3S, CAS 852438-15-4
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-fluorobenzamide
CAS 852438-15-4C17H13ClFNO3S
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide chemical structure, C19H18ClNO5S, CAS 863007-36-7
N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,5-dimethoxybenzamide
CAS 863007-36-7C19H18ClNO5S
N-(4-Chlorophenyl)-4-(N,N-dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide chemical structure, C19H19ClN2O5S2, CAS 863007-41-4
N-(4-Chlorophenyl)-4-(N,N-dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide
CAS 863007-41-4C19H19ClN2O5S2
N-(3-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2,4-dimethoxybenzamide chemical structure, C19H18ClNO5S, CAS 863007-83-4
N-(3-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2,4-dimethoxybenzamide
CAS 863007-83-4C19H18ClNO5S
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,4-diethoxybenzamide chemical structure, C22H24ClNO5S, CAS 863007-95-8
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-3,4-diethoxybenzamide
CAS 863007-95-8C22H24ClNO5S
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-ethoxybenzamide chemical structure, C20H20ClNO4S, CAS 863008-12-2
N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-ethoxybenzamide
CAS 863008-12-2C20H20ClNO4S
4-Butoxy-N-(3-chloro-4-methylphenyl)-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)benzamide chemical structure, C22H24ClNO4S, CAS 863008-13-3
4-Butoxy-N-(3-chloro-4-methylphenyl)-N-(1,1-dioxo-2,3-dihydro-1lambda6-thiophen-3-yl)benzamide
CAS 863008-13-3C22H24ClNO4S
N-(3-Chloro-4-methylphenyl)-4-(N,N-dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide chemical structure, C20H21ClN2O5S2, CAS 863008-23-5
N-(3-Chloro-4-methylphenyl)-4-(N,N-dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)benzamide
CAS 863008-23-5C20H21ClN2O5S2
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-2-ethoxy-N-(p-tolyl)benzamide chemical structure, C20H21NO4S, CAS 863008-33-7
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-2-ethoxy-N-(p-tolyl)benzamide
CAS 863008-33-7C20H21NO4S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-3,4-diethoxy-N-(4-ethoxyphenyl)benzamide chemical structure, C23H27NO6S, CAS 863020-81-9
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-3,4-diethoxy-N-(4-ethoxyphenyl)benzamide
CAS 863020-81-9C23H27NO6S
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)-4-methylbenzamide chemical structure, C20H21NO4S, CAS 852438-43-8
N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)-4-methylbenzamide
CAS 852438-43-8C20H21NO4S
3-Bromo-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide chemical structure, C19H18BrNO4S, CAS 863020-97-7
3-Bromo-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide
CAS 863020-97-7C19H18BrNO4S
4-(N,N-Diethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide chemical structure, C23H28N2O6S2, CAS 863021-03-8
4-(N,N-Diethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide
CAS 863021-03-8C23H28N2O6S2
4-(N,N-Dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide chemical structure, C21H24N2O6S2, CAS 863021-04-9
4-(N,N-Dimethylsulfamoyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)benzamide
CAS 863021-04-9C21H24N2O6S2