Murcko scaffold
Ring system with 4 rings and 25 atoms
28 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 28
- With full pages
- 2
Scaffold SMILES
O=C(NCCc1ccsc1)OCC1c2ccccc2-c2ccccc21
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 28 of 28 chemicals
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid
CAS 186320-06-9C22H19NO4S
Fmoc-(S)-3-Amino-4-(3-thienyl)-butyric acid
CAS 270263-01-9C23H21NO4S
FMOC-DL-3-thienylalanine
CAS 678991-94-1C22H19NO4S
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid
CAS 220497-90-5C22H19NO4S
Fmoc-(R)-3-Amino-4-(3-thienyl)-butyric acid
CAS 269726-93-4C23H21NO4S
![(9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-3-yl)ethyl]carbamate chemical structure, C21H19NO3S, CAS 1695914-03-4](/s/CZEBZZFIWUTTRJ-UHFFFAOYSA-N.svg)
(9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-3-yl)ethyl]carbamate
CAS 1695914-03-4C21H19NO3S
![2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(trifluoromethyl)thiophen-3-yl]propanoic acid chemical structure, C23H18F3NO4S, CAS 2287261-02-1](/s/UKIXZKKOAHWXOR-UHFFFAOYSA-N.svg)
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(trifluoromethyl)thiophen-3-yl]propanoic acid
CAS 2287261-02-1C23H18F3NO4S
3-(2,5-Dibromothiophen-3-yl)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid
CAS 2287267-84-7C22H17Br2NO4S
![3-(5-Cyanothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C23H18N2O4S, CAS 2387321-50-6](/s/RVRNLGDLHKVMCJ-UHFFFAOYSA-N.svg)
3-(5-Cyanothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 2387321-50-6C23H18N2O4S
![3-(2-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1849564-32-4](/s/JLCYQFJDMUDMTC-UHFFFAOYSA-N.svg)
3-(2-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1849564-32-4C22H18BrNO4S
![3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-4-(thiophen-3-yl)butanoic acid chemical structure, C24H23NO4S, CAS 2162645-08-9](/s/HZTGADXYCKUKJC-UHFFFAOYSA-N.svg)
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-4-(thiophen-3-yl)butanoic acid
CAS 2162645-08-9C24H23NO4S
![3-(5-Chlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoicacid chemical structure, C22H18ClNO4S, CAS 1849935-73-4](/s/IFICZWFJZNSDIO-UHFFFAOYSA-N.svg)
3-(5-Chlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoicacid
CAS 1849935-73-4C22H18ClNO4S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methylthiophen-3-yl)propanoic acid chemical structure, C23H21NO4S, CAS 2171725-05-4](/s/XSDONQGBDVGVMO-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-methylthiophen-3-yl)propanoic acid
CAS 2171725-05-4C23H21NO4S
![5-(2-Chlorothiophen-3-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoic acid chemical structure, C24H22ClNO4S, CAS 1999830-17-9](/s/LJCVZSMVKWZGMR-UHFFFAOYSA-N.svg)
5-(2-Chlorothiophen-3-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoic acid
CAS 1999830-17-9C24H22ClNO4S
![3-(2-Chlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 1999145-62-8](/s/YJOKWAVKOGLCGA-UHFFFAOYSA-N.svg)
3-(2-Chlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1999145-62-8C22H18ClNO4S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methylthiophen-3-yl)propanoic acid chemical structure, C23H21NO4S, CAS 1869588-07-7](/s/INUXKAODELHZLY-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methylthiophen-3-yl)propanoic acid
CAS 1869588-07-7C23H21NO4S
![3-(2,5-Dichlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H17Cl2NO4S, CAS 1993848-88-6](/s/OKGSYJBLGDNYHH-UHFFFAOYSA-N.svg)
3-(2,5-Dichlorothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1993848-88-6C22H17Cl2NO4S
![(2S)-3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1997405-61-4](/s/ZXECEYSAQBGFMU-IBGZPJMESA-N.svg)
(2S)-3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1997405-61-4C22H18BrNO4S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(2,4,5-trichlorothiophen-3-yl)propanoic acid chemical structure, C22H16Cl3NO4S, CAS 2680587-10-2](/s/QKIKNBCQBDYWQQ-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(2,4,5-trichlorothiophen-3-yl)propanoic acid
CAS 2680587-10-2C22H16Cl3NO4S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-[5-(trifluoromethyl)thiophen-3-yl]propanoic acid chemical structure, C23H18F3NO4S, CAS 2148661-04-3](/s/JDZCFGGVMNSCKX-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-[5-(trifluoromethyl)thiophen-3-yl]propanoic acid
CAS 2148661-04-3C23H18F3NO4S
![3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1869121-72-1](/s/ZXECEYSAQBGFMU-UHFFFAOYSA-N.svg)
3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1869121-72-1C22H18BrNO4S
![(2R)-3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1997374-55-6](/s/ZXECEYSAQBGFMU-LJQANCHMSA-N.svg)
(2R)-3-(5-Bromothiophen-3-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1997374-55-6C22H18BrNO4S
![(9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-3-yl)ethyl]-N-methylcarbamate chemical structure, C22H21NO3S, CAS 2763920-08-5](/s/LODKTGPKXPNFKR-UHFFFAOYSA-N.svg)
(9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-3-yl)ethyl]-N-methylcarbamate
CAS 2763920-08-5C22H21NO3S
![(9H-Fluoren-9-yl)methyl N-[1-(2,5-dichlorothiophen-3-yl)-3-hydroxypropan-2-yl]carbamate chemical structure, C22H19Cl2NO3S, CAS 2763918-85-8](/s/QZCKIQAELGCURO-UHFFFAOYSA-N.svg)
(9H-Fluoren-9-yl)methyl N-[1-(2,5-dichlorothiophen-3-yl)-3-hydroxypropan-2-yl]carbamate
CAS 2763918-85-8C22H19Cl2NO3S
- (9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-3-yl)propyl]carbamate2764001-19-4C22H21NO3S
- 2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-nitrothiophen-3-yl)propanoic acid1379880-49-5C22H18N2O6S
- (2S)-2-[9H-Fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-(3-thienyl)propanoic acid2865160-68-3C23H21NO4S
- Fmoc-L-3-thiophene(2,5-2Me)-OH2002530-86-9C24H23NO4S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(NCCc1nccs1)OCC1c2ccccc2-c2ccccc217 chemicals![Scaffold O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc21](/scaffold/YSCVHHRVDCKDEK-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc215 chemicals
O=C(NCC(=O)N1CCOC1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCc1cccs1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCc1ccco1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCn1cccn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(CCn1c2c(c3ccccc31)CCCC2)NN=Cc1ccco12 chemicals
O=C(NCCc1cscn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(NCCC1CCCC1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc21](/scaffold/ZXNLBXPPRVWTTQ-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc21](/scaffold/DXVOSQOYLKBPSU-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc211 chemical
O=C(NCCn1cncn1)OCC1c2ccccc2-c2ccccc211 chemical