Murcko scaffold
Ring system with 4 rings and 25 atoms
112 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 112
- With full pages
- 7
Scaffold SMILES
O=C(NCCc1nccs1)OCC1c2ccccc2-c2ccccc21
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 112 chemicals
![2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazole-4-carboxylic acid chemical structure, C21H18N2O4S, CAS 1508208-26-1](/s/NEYKGMWFAPTGND-UHFFFAOYSA-N.svg)
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazole-4-carboxylic acid
CAS 1508208-26-1C21H18N2O4S
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiazol-2-yl)propanoic acid
CAS 1379862-69-7C21H18N2O4S
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methylthiazol-2-yl)propanoic acid
CAS 1379844-17-3C22H20N2O4S
![3-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C23H22N2O4S, CAS 1702638-41-2](/s/ZSTCIPVRKGTMLI-UHFFFAOYSA-N.svg)
3-(4,5-Dimethyl-1,3-thiazol-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1702638-41-2C23H22N2O4S
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiazol-2-yl)propanoic acid
CAS 1306728-64-2C21H18N2O4S
![(2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(1,3-thiazol-2-yl)propanoic acid chemical structure, C21H18N2O4S, CAS 1987261-05-1](/s/HBHYBVLFMJXMIX-GOSISDBHSA-N.svg)
(2R)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(1,3-thiazol-2-yl)propanoic acid
CAS 1987261-05-1C21H18N2O4S
![2-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-4-methyl-1,3-thiazole-5-carboxylic acid chemical structure, C22H20N2O4S, CAS 2092501-01-2](/s/ZMAYXELJHIDUHU-UHFFFAOYSA-N.svg)
2-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-4-methyl-1,3-thiazole-5-carboxylic acid
CAS 2092501-01-2C22H20N2O4S
![2-[2-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-1,3-thiazol-4-yl]acetic acid chemical structure, C22H20N2O4S, CAS 2138372-34-4](/s/GXIRZXZBHDXTLC-UHFFFAOYSA-N.svg)
2-[2-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethyl)-1,3-thiazol-4-yl]acetic acid
CAS 2138372-34-4C22H20N2O4S
![(3S)-3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)butanoic acid chemical structure, C26H27N3O5S, CAS 2171203-89-5](/s/WTTJRDHMBYGXRO-HNNXBMFYSA-N.svg)
(3S)-3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)butanoic acid
CAS 2171203-89-5C26H27N3O5S
![4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)butanoic acid chemical structure, C26H27N3O5S, CAS 2172278-59-8](/s/KOVSFROKIDMZRO-UHFFFAOYSA-N.svg)
4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)butanoic acid
CAS 2172278-59-8C26H27N3O5S
![2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazole-5-carboxylic acid chemical structure, C21H18N2O4S, CAS 2138205-25-9](/s/OQHBIPPWOSKNLG-UHFFFAOYSA-N.svg)
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazole-5-carboxylic acid
CAS 2138205-25-9C21H18N2O4S
![2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazole-4-carboxylic acid chemical structure, C22H20N2O4S, CAS 2138144-47-3](/s/RLFJGEQSZIEQBG-UHFFFAOYSA-N.svg)
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazole-4-carboxylic acid
CAS 2138144-47-3C22H20N2O4S
![(2S)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)propanoic acid chemical structure, C24H23N3O5S, CAS 2171201-57-1](/s/LJIOZBSYDNRUAS-AWEZNQCLSA-N.svg)
(2S)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)propanoic acid
CAS 2171201-57-1C24H23N3O5S
![2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-methylformamido)acetic acid chemical structure, C24H23N3O5S, CAS 2171942-65-5](/s/DHTNVJSAGHDJJV-UHFFFAOYSA-N.svg)
2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-methylformamido)acetic acid
CAS 2171942-65-5C24H23N3O5S
![3-(5-Bromo-1,3-thiazol-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C21H17BrN2O4S, CAS 2148611-12-3](/s/IOFMDCALANJTFB-UHFFFAOYSA-N.svg)
3-(5-Bromo-1,3-thiazol-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 2148611-12-3C21H17BrN2O4S
![4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid chemical structure, C25H25N3O5S, CAS 2172520-70-4](/s/BPCWLINKBUMSSA-UHFFFAOYSA-N.svg)
4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid
CAS 2172520-70-4C25H25N3O5S
![2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid chemical structure, C25H25N3O5S, CAS 2171768-98-0](/s/MMZGLKCJVDEPDD-UHFFFAOYSA-N.svg)
2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid
CAS 2171768-98-0C25H25N3O5S
![2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methylbutanoic acid chemical structure, C26H27N3O5S, CAS 2648982-51-6](/s/AXSQLDWLKUZYQZ-UHFFFAOYSA-N.svg)
2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methylbutanoic acid
CAS 2648982-51-6C26H27N3O5S
![3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-hydroxy-2-methylpropanoic acid chemical structure, C25H25N3O6S, CAS 2172503-84-1](/s/PJFXIYLJVCXPQQ-UHFFFAOYSA-N.svg)
3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-hydroxy-2-methylpropanoic acid
CAS 2172503-84-1C25H25N3O6S
![4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)pentanoic acid chemical structure, C26H27N3O5S, CAS 2172048-79-0](/s/GKTBRDSRMQHUKY-UHFFFAOYSA-N.svg)
4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)pentanoic acid
CAS 2172048-79-0C26H27N3O5S
![3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)propanoic acid chemical structure, C24H23N3O5S, CAS 2172391-16-9](/s/VLGIHPOWTUEWQC-UHFFFAOYSA-N.svg)
3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)propanoic acid
CAS 2172391-16-9C24H23N3O5S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methyl-1,3-thiazol-2-yl)propanoic acid chemical structure, C22H20N2O4S, CAS 1849650-69-6](/s/UAVPPRQMKCPCFC-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(5-methyl-1,3-thiazol-2-yl)propanoic acid
CAS 1849650-69-6C22H20N2O4S
![4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)but-2-ynoic acid chemical structure, C25H21N3O5S, CAS 2172560-47-1](/s/UNIVISWLJZBRRB-UHFFFAOYSA-N.svg)
4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)but-2-ynoic acid
CAS 2172560-47-1C25H21N3O5S
![(2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-4-hydroxybutanoic acid chemical structure, C25H25N3O6S, CAS 2171211-69-9](/s/HVEZMPMUOLFYQV-HXUWFJFHSA-N.svg)
(2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-4-hydroxybutanoic acid
CAS 2171211-69-9C25H25N3O6S
- 3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methoxypropanoic acid2172461-93-5C25H25N3O6S
- 4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)but-2-enoic acid2172615-17-5C26H25N3O5S
- 2-[({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-5-methyl-1,3-thiazol-4-yl}formamido)oxy]acetic acid2172112-31-9C24H23N3O6S
- 2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-(2-hydroxyethyl)formamido)acetic acid2172103-02-3C25H25N3O6S
- 2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-(prop-2-yn-1-yl)formamido)acetic acid2172115-68-1C26H23N3O5S
- 3-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-methylformamido)-2-methylpropanoic acid2171877-17-9C26H27N3O5S
- (2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-3-methylbutanoic acid2171200-55-6C26H27N3O5S
- 2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-methylformamido)butanoic acid2171574-70-0C26H27N3O5S
- (2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)pentanoic acid2171258-58-3C26H27N3O5S
- 3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methylbutanoic acid2172131-05-2C26H27N3O5S
- 4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methylbutanoic acid2171819-40-0C26H27N3O5S
- 2-(N-Ethyl-1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)acetic acid2171882-79-2C25H25N3O5S
- (2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid2171261-09-7C25H25N3O5S
- (2S)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-3-methylbutanoic acid2171213-02-6C26H27N3O5S
- (2S)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-3-hydroxypropanoic acid2171142-95-1C24H23N3O6S
- 3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2-methylpropanoic acid2172372-16-4C25H25N3O5S
- 2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)pent-4-enoic acid2171711-83-2C26H25N3O5S
- 3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-2,2-difluoropropanoic acid2172469-66-6C24H21F2N3O5S
- 2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-(propan-2-yl)formamido)acetic acid2171984-67-9C26H27N3O5S
- 3-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-3-methylbutanoic acid2172310-62-0C26H27N3O5S
- 2-(1-{2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}-N-(prop-2-en-1-yl)formamido)acetic acid2171845-87-5C26H25N3O5S
- 4-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)but-2-enoic acid2172607-73-5C25H23N3O5S
- (2S)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)butanoic acid2171264-33-6C25H25N3O5S
- (2R)-2-({2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-1,3-thiazol-4-yl}formamido)-3-hydroxypropanoic acid2171214-95-0C24H23N3O6S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc21](/scaffold/YSCVHHRVDCKDEK-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc215 chemicals
O=C(NCC(=O)N1CCOC1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCc1cccs1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCc1ccco1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCn1cccn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(CCn1c2c(c3ccccc31)CCCC2)NN=Cc1ccco12 chemicals
O=C(NCCc1cscn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(NCCC1CCCC1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(NCCc1ccsc1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc21](/scaffold/ZXNLBXPPRVWTTQ-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc21](/scaffold/DXVOSQOYLKBPSU-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc211 chemical
O=C(NCCn1cncn1)OCC1c2ccccc2-c2ccccc211 chemical