Murcko scaffold
Ring system with 4 rings and 25 atoms
50 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 50
- With full pages
- 3
Scaffold SMILES
O=C(NCCc1cccs1)OCC1c2ccccc2-c2ccccc21
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 50 chemicals
Fmoc-D-2-(5-bromothienyl)alanine
CAS 220497-83-6C22H18BrNO4S
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid
CAS 201532-42-5C22H19NO4S
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(thiophen-2-yl)butanoic acid
CAS 270262-98-1C23H21NO4S
2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid
CAS 134439-24-0C22H19NO4S
Fmoc-L-2-(5-bromothienyl)alanine
CAS 220497-50-7C22H18BrNO4S
(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(thiophen-2-yl)butanoic acid
CAS 269726-90-1C23H21NO4S
Fmoc-L-2-Thienylalanine
CAS 130309-35-2C22H19NO4S
![3-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1695686-65-7](/s/ABNLVFDGUSJGFG-UHFFFAOYSA-N.svg)
3-(5-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1695686-65-7C22H18BrNO4S
![3-(5-Chlorothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18ClNO4S, CAS 1379834-52-2](/s/PFKCQTDHGFPRNP-UHFFFAOYSA-N.svg)
3-(5-Chlorothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1379834-52-2C22H18ClNO4S
![3-(3-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1379880-81-5](/s/NCESHFLJYLXTLF-UHFFFAOYSA-N.svg)
3-(3-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1379880-81-5C22H18BrNO4S
![3-(5-Ethylthiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H23NO4S, CAS 1379887-08-7](/s/NEAKAQSTBHUUFJ-UHFFFAOYSA-N.svg)
3-(5-Ethylthiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1379887-08-7C24H23NO4S
![3-(4-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C22H18BrNO4S, CAS 1379874-25-5](/s/JTTPRZNXFKPFOF-UHFFFAOYSA-N.svg)
3-(4-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 1379874-25-5C22H18BrNO4S
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-methyl-2-thienyl)propanoic acid
CAS 1379879-62-5C23H21NO4S
2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(5-methyl-2-thienyl)propanoic acid
CAS 1379857-16-5C23H21NO4S
3-(4-Chloro-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
CAS 1701639-53-3C22H18ClNO4S
(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-methyl-2-thienyl)propanoic acid
CAS 1306728-48-2C23H21NO4S
(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3-methyl-2-thienyl)propanoic acid
CAS 1986906-39-1C23H21NO4S
![2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}[2-(thiophen-2-yl)ethyl]amino)acetic acid chemical structure, C23H21NO4S, CAS 2094641-12-8](/s/UQMYGAFCSPLEKF-UHFFFAOYSA-N.svg)
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}[2-(thiophen-2-yl)ethyl]amino)acetic acid
CAS 2094641-12-8C23H21NO4S
![(9H-Fluoren-9-yl)methyl N-[1-hydroxy-3-(thiophen-2-yl)propan-2-yl]carbamate chemical structure, C22H21NO3S, CAS 1823289-43-5](/s/XSXZHRHDWUMEIM-UHFFFAOYSA-N.svg)
(9H-Fluoren-9-yl)methyl N-[1-hydroxy-3-(thiophen-2-yl)propan-2-yl]carbamate
CAS 1823289-43-5C22H21NO3S
N-Fmoc-N-methyl-3-(2-thienyl)-L-alanine
CAS 1332600-71-1C23H21NO4S
![5-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethyl]thiophene-2-carboxylic acid chemical structure, C22H19NO4S, CAS 2490418-63-6](/s/HCZKSBSUVDFDPM-UHFFFAOYSA-N.svg)
5-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethyl]thiophene-2-carboxylic acid
CAS 2490418-63-6C22H19NO4S
![3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-4-(thiophen-2-yl)butanoic acid chemical structure, C24H23NO4S, CAS 2172029-39-7](/s/QDUMZQOPGWPWPD-UHFFFAOYSA-N.svg)
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-4-(thiophen-2-yl)butanoic acid
CAS 2172029-39-7C24H23NO4S
![2-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxypropanoic acid chemical structure, C22H18ClNO5S, CAS 2757959-89-8](/s/MEMSUEACESFFJB-UHFFFAOYSA-N.svg)
2-(5-Chlorothiophen-2-yl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-hydroxypropanoic acid
CAS 2757959-89-8C22H18ClNO5S
![3-(5-Bromothiophen-2-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid chemical structure, C23H20BrNO4S, CAS 2137568-05-7](/s/UMZOVSDNPDVFSJ-UHFFFAOYSA-N.svg)
3-(5-Bromothiophen-2-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
CAS 2137568-05-7C23H20BrNO4S
- (2S)-3-(3-Bromothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid1997455-67-0C22H18BrNO4S
- 3-(3-Chlorothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid1849855-13-5C22H18ClNO4S
- (9H-Fluoren-9-yl)methyl N-[2-(5-chlorothiophen-2-yl)-2-hydroxyethyl]carbamate2680838-05-3C21H18ClNO3S
- 2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-[4-(trifluoromethyl)thiophen-2-yl]propanoic acid2383843-09-0C23H18F3NO4S
- 3-(4-Bromothiophen-2-yl)-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid2138378-83-1C23H20BrNO4S
- (9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-2-yl)propyl]carbamate2763998-85-0C22H21NO3S
- (9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-2-yl)ethyl]carbamate2764009-13-2C21H19NO3S
- (9H-Fluoren-9-yl)methyl N-[2-hydroxy-2-(thiophen-2-yl)ethyl]-N-methylcarbamate2763955-52-6C22H21NO3S
- Fmoc-3-(3-chlorothiophen-2-yl)-L-alanine1998574-24-5C22H18ClNO4S
- Fmoc-3-(3-bromothiophen-2-yl)-D-alanine1998625-51-6C22H18BrNO4S
- Fmoc-3-(3-chlorothiophen-2-yl)-D-alanine1998591-86-8C22H18ClNO4S
- (2S)-Fmoc-3-(5-methylthien-2-yl)alanine2015396-14-0C23H21NO4S
- Fmoc-3-(4-methylthien-2-yl)-L-alanine2350489-22-2C23H21NO4S
- 3-(4-Bromo-5-chlorothiophen-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid2995272-82-5C22H17BrClNO5S
- (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(5-methyl-2-thienyl)propanoic acid1998628-16-2C23H21NO4S
- (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-methyl-2-thienyl)propanoic acid2350017-44-4C23H21NO4S
- 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-methyl-2-thienyl)propanoic acid2352509-10-3C23H21NO4S
- 3-(3,5-Dimethyl-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid2145518-78-9C24H23NO4S
- (2S)-3-(3,5-Dimethyl-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid2145021-60-7C24H23NO4S
- (2R)-3-(3,5-Dimethyl-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid2136912-17-7C24H23NO4S
- (2R)-3-(4-Chloro-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid1997416-98-4C22H18ClNO4S
- (2R)-3-(5-Chloro-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid1998625-73-2C22H18ClNO4S
- (2S)-3-(4-Chloro-2-thienyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid1997423-60-5C22H18ClNO4S
- 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[5-(trifluoromethyl)-2-thienyl]propanoic acid2352107-57-2C23H18F3NO4S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(NCCc1nccs1)OCC1c2ccccc2-c2ccccc217 chemicals![Scaffold O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc21](/scaffold/YSCVHHRVDCKDEK-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]cn1)OCC1c2ccccc2-c2ccccc215 chemicals
O=C(NCC(=O)N1CCOC1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCc1ccco1)OCC1c2ccccc2-c2ccccc213 chemicals
O=C(NCCn1cccn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(CCn1c2c(c3ccccc31)CCCC2)NN=Cc1ccco12 chemicals
O=C(NCCc1cscn1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(NCCC1CCCC1)OCC1c2ccccc2-c2ccccc212 chemicals
O=C(NCCc1ccsc1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc21](/scaffold/ZXNLBXPPRVWTTQ-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1cn[nH]c1)OCC1c2ccccc2-c2ccccc212 chemicals![Scaffold O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc21](/scaffold/DXVOSQOYLKBPSU-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1c[nH]c(=O)[nH]1)OCC1c2ccccc2-c2ccccc211 chemical
O=C(NCCn1cncn1)OCC1c2ccccc2-c2ccccc211 chemical