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Murcko scaffold

Ring system with 2 rings and 16 atoms

25 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
25
With full pages
6
Scaffold SMILES

O=C(CSC1=NCCS1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSC1=NCCS1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

N-(2,4-Difluorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide chemical structure, C11H10F2N2OS2, CAS 309739-96-6
N-(2,4-Difluorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide
CAS 309739-96-6C11H10F2N2OS2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C12H11F3N2OS2, CAS 330555-66-3
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 330555-66-3C12H11F3N2OS2
N-(2-Cyanophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide chemical structure, C12H11N3OS2, CAS 389083-72-1
N-(2-Cyanophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide
CAS 389083-72-1C12H11N3OS2
N-(3-Acetylphenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide chemical structure, C13H14N2O2S2, CAS 350845-02-2
N-(3-Acetylphenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide
CAS 350845-02-2C13H14N2O2S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2-methoxyphenyl)acetamide chemical structure, C12H14N2O2S2, CAS 444160-98-9
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2-methoxyphenyl)acetamide
CAS 444160-98-9C12H14N2O2S2
Methyl 4-(2-((4,5-dihydrothiazol-2-yl)thio)acetamido)benzoate chemical structure, C13H14N2O3S2, CAS 444164-70-9
Methyl 4-(2-((4,5-dihydrothiazol-2-yl)thio)acetamido)benzoate
CAS 444164-70-9C13H14N2O3S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-ethoxyphenyl)acetamide chemical structure, C13H16N2O2S2, CAS 403834-93-5
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-ethoxyphenyl)acetamide
CAS 403834-93-5C13H16N2O2S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C13H16N2O3S2, CAS 444165-08-6
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,5-dimethoxyphenyl)acetamide
CAS 444165-08-6C13H16N2O3S2
N-(4-Methylphenyl)-2-(1,3-thiazolin-2-ylthio)acetamide chemical structure, C12H14N2OS2, CAS 5303-59-3
N-(4-Methylphenyl)-2-(1,3-thiazolin-2-ylthio)acetamide
CAS 5303-59-3C12H14N2OS2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4-dimethylphenyl)acetamide chemical structure, C13H16N2OS2, CAS 403835-59-6
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4-dimethylphenyl)acetamide
CAS 403835-59-6C13H16N2OS2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,5-dimethylphenyl)acetamide chemical structure, C13H16N2OS2, CAS 403835-46-1
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,5-dimethylphenyl)acetamide
CAS 403835-46-1C13H16N2OS2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-methoxyphenyl)acetamide chemical structure, C12H14N2O2S2, CAS 403834-83-3
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-methoxyphenyl)acetamide
CAS 403834-83-3C12H14N2O2S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C13H16N2O3S2, CAS 403835-94-9
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4-dimethoxyphenyl)acetamide
CAS 403835-94-9C13H16N2O3S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-sulfamoylphenyl)acetamide chemical structure, C11H13N3O3S3, CAS 296772-57-1
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-sulfamoylphenyl)acetamide
CAS 296772-57-1C11H13N3O3S3
Dimethyl 5-{[(4,5-dihydro-1,3-thiazol-2-ylthio)acetyl]amino}isophthalate chemical structure, C15H16N2O5S2, CAS 825655-79-6
Dimethyl 5-{[(4,5-dihydro-1,3-thiazol-2-ylthio)acetyl]amino}isophthalate
CAS 825655-79-6C15H16N2O5S2
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide chemical structure, C13H15ClN2O2S2, CAS 380170-00-3
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide
CAS 380170-00-3C13H15ClN2O2S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-methyl-N-phenylacetamide chemical structure, C12H14N2OS2, CAS 380484-50-4
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-methyl-N-phenylacetamide
CAS 380484-50-4C12H14N2OS2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-sulfamoylphenyl)butanamide chemical structure, C13H17N3O3S3, CAS 311800-86-9
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(4-sulfamoylphenyl)butanamide
CAS 311800-86-9C13H17N3O3S3
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2-methoxyphenyl)butanamide chemical structure, C14H18N2O2S2, CAS 522650-88-0
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2-methoxyphenyl)butanamide
CAS 522650-88-0C14H18N2O2S2
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4,5-trichlorophenyl)acetamide chemical structure, C11H9Cl3N2OS2, CAS 443653-52-9
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-N-(2,4,5-trichlorophenyl)acetamide
CAS 443653-52-9C11H9Cl3N2OS2
2-((4,5-Dihydrothiazol-2-yl)thio)-N-(p-tolyl)propanamide chemical structure, C13H16N2OS2, CAS 638999-98-1
2-((4,5-Dihydrothiazol-2-yl)thio)-N-(p-tolyl)propanamide
CAS 638999-98-1C13H16N2OS2
2-[[2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)acetyl]amino]benzamide chemical structure, C12H13N3O2S2, CAS 444166-13-6
2-[[2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)acetyl]amino]benzamide
CAS 444166-13-6C12H13N3O2S2
N-(4-Bromophenyl)-2-((4,5-dihydrothiazol-2-yl)thio)acetamide chemical structure, C11H11BrN2OS2, CAS 403835-03-0
N-(4-Bromophenyl)-2-((4,5-dihydrothiazol-2-yl)thio)acetamide
CAS 403835-03-0C11H11BrN2OS2
N-(3,4-Difluorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide chemical structure, C11H10F2N2OS2, CAS 1188964-68-2
N-(3,4-Difluorophenyl)-2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)acetamide
CAS 1188964-68-2C11H10F2N2OS2