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Murcko scaffold

Ring system with 3 rings and 20 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
29
With full pages
5
Scaffold SMILES

S=c1[nH]nc(-c2cccnc2)n1N=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1[nH]nc(-c2cccnc2)n1N=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

4-[(E)-(2-Fluorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H10FN5S, CAS 497867-54-6
4-[(E)-(2-Fluorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 497867-54-6C14H10FN5S
4-[(E)-(4-tert-Butylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C18H19N5S, CAS 488853-17-4
4-[(E)-(4-tert-Butylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488853-17-4C18H19N5S
4-[(E)-(4-Methylsulfanylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C15H13N5S2, CAS 488826-72-8
4-[(E)-(4-Methylsulfanylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488826-72-8C15H13N5S2
4-[(E)-Benzylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H11N5S, CAS 1016895-23-0
4-[(E)-Benzylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 1016895-23-0C14H11N5S
4-{[4-(Dimethylamino)benzylidene]amino}-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C16H16N6S, CAS 89814-09-5
4-{[4-(Dimethylamino)benzylidene]amino}-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 89814-09-5C16H16N6S
4-[(E)-(4-Propan-2-ylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C17H17N5S, CAS 487037-65-0
4-[(E)-(4-Propan-2-ylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 487037-65-0C17H17N5S
4-[(2-Chloro-6-fluorobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H9ClFN5S, CAS 500270-62-2
4-[(2-Chloro-6-fluorobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 500270-62-2C14H9ClFN5S
4-[(3-Nitrobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10N6O2S, CAS 89814-11-9
4-[(3-Nitrobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 89814-11-9C14H10N6O2S
4-[(E)-(3-Methylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C15H13N5S, CAS 500146-92-9
4-[(E)-(3-Methylphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 500146-92-9C15H13N5S
4-[(2-Nitrobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol chemical structure, C14H10N6O2S, CAS 488860-85-1
4-[(2-Nitrobenzylidene)amino]-5-(3-pyridinyl)-4H-1,2,4-triazole-3-thiol
CAS 488860-85-1C14H10N6O2S
Methyl 4-[(E)-(3-pyridin-3-yl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)iminomethyl]benzoate chemical structure, C16H13N5O2S, CAS 488724-71-6
Methyl 4-[(E)-(3-pyridin-3-yl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)iminomethyl]benzoate
CAS 488724-71-6C16H13N5O2S
4-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C16H15N5O2S, CAS 489421-45-6
4-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 489421-45-6C16H15N5O2S
4-[(E)-(2-Bromophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H10BrN5S, CAS 488715-70-4
4-[(E)-(2-Bromophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488715-70-4C14H10BrN5S
3-Pyridin-3-yl-4-[(E)-(2,3,4-trimethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione chemical structure, C17H17N5O3S, CAS 487023-04-1
3-Pyridin-3-yl-4-[(E)-(2,3,4-trimethoxyphenyl)methylideneamino]-1H-1,2,4-triazole-5-thione
CAS 487023-04-1C17H17N5O3S
2-[2-[(E)-(3-Pyridin-3-yl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)iminomethyl]phenoxy]acetic acid chemical structure, C16H13N5O3S, CAS 497230-76-9
2-[2-[(E)-(3-Pyridin-3-yl-5-sulfanylidene-1H-1,2,4-triazol-4-yl)iminomethyl]phenoxy]acetic acid
CAS 497230-76-9C16H13N5O3S
4-[(E)-(2,3-Dichlorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H9Cl2N5S, CAS 488137-43-5
4-[(E)-(2,3-Dichlorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488137-43-5C14H9Cl2N5S
4-[(E)-(3-Bromophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H10BrN5S, CAS 488121-68-2
4-[(E)-(3-Bromophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488121-68-2C14H10BrN5S
4-[(E)-[4-(Diethylamino)phenyl]methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C18H20N6S, CAS 488827-35-6
4-[(E)-[4-(Diethylamino)phenyl]methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488827-35-6C18H20N6S
4-[(E)-(2,4-Dichlorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H9Cl2N5S, CAS 488794-09-8
4-[(E)-(2,4-Dichlorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 488794-09-8C14H9Cl2N5S
4-[(E)-(5-Bromo-2-fluorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione chemical structure, C14H9BrFN5S, CAS 497247-93-5
4-[(E)-(5-Bromo-2-fluorophenyl)methylideneamino]-3-pyridin-3-yl-1H-1,2,4-triazole-5-thione
CAS 497247-93-5C14H9BrFN5S
4-{[(E)-(5-Bromo-2-methoxyphenyl)methylidene]amino}-5-(pyridin-3-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione chemical structure, C15H12BrN5OS, CAS 487031-11-8
4-{[(E)-(5-Bromo-2-methoxyphenyl)methylidene]amino}-5-(pyridin-3-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
CAS 487031-11-8C15H12BrN5OS
2-(((3-Mercapto-5-(3-pyridinyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol chemical structure, C14H11N5OS, CAS 89814-04-0
2-(((3-Mercapto-5-(3-pyridinyl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol
CAS 89814-04-0C14H11N5OS
(E)-2-Ethoxy-4-(((3-mercapto-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol chemical structure, C16H15N5O2S, CAS 488111-13-3
(E)-2-Ethoxy-4-(((3-mercapto-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol
CAS 488111-13-3C16H15N5O2S
(E)-2-Ethoxy-6-(((3-mercapto-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol chemical structure, C16H15N5O2S, CAS 488794-12-3
(E)-2-Ethoxy-6-(((3-mercapto-5-(pyridin-3-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)phenol
CAS 488794-12-3C16H15N5O2S