Murcko scaffold
Ring system with 2 rings and 17 atoms
47 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 17
- Chemicals
- 47
- With full pages
- 6
Scaffold SMILES
O=C(NC(=S)Nc1ccccc1)c1ccn[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(NC(=S)Nc1ccccc1)c1ccn[nH]1](/scaffold/XTWYLLMGZFELNU-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 47 of 47 chemicals
![N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-methylpyrazole-3-carboxamide chemical structure, C14H16N4O3S, CAS 309275-85-2](/s/PLKAEFKZZLRAEF-UHFFFAOYSA-N.svg)
N-[(2,5-Dimethoxyphenyl)carbamothioyl]-2-methylpyrazole-3-carboxamide
CAS 309275-85-2C14H16N4O3S
![N-[(4-Chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]-N'-(3-methoxyphenyl)thiourea chemical structure, C14H15ClN4O2S, CAS 515873-55-9](/s/NXZFDXOORDLROU-UHFFFAOYSA-N.svg)
N-[(4-Chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]-N'-(3-methoxyphenyl)thiourea
CAS 515873-55-9C14H15ClN4O2S
![N-[(4-Chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]-N'-(2-hydroxyphenyl)thiourea chemical structure, C13H13ClN4O2S, CAS 494219-43-1](/s/INAPSNDMUYIEFW-UHFFFAOYSA-N.svg)
N-[(4-Chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]-N'-(2-hydroxyphenyl)thiourea
CAS 494219-43-1C13H13ClN4O2S
![4-Bromo-1-ethyl-N-[(4-iodophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C13H12BrIN4OS, CAS 492425-66-8](/s/MHCSCSKWJFQVLE-UHFFFAOYSA-N.svg)
4-Bromo-1-ethyl-N-[(4-iodophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 492425-66-8C13H12BrIN4OS
![4-Bromo-1-ethyl-N-[(2-iodophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C13H12BrIN4OS, CAS 492425-75-9](/s/DPXUNPWORHZTPB-UHFFFAOYSA-N.svg)
4-Bromo-1-ethyl-N-[(2-iodophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 492425-75-9C13H12BrIN4OS
![4-Bromo-1-ethyl-N-[(4-iodo-2-methylphenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C14H14BrIN4OS, CAS 492425-79-3](/s/NGHYSSSCFRFCFU-UHFFFAOYSA-N.svg)
4-Bromo-1-ethyl-N-[(4-iodo-2-methylphenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 492425-79-3C14H14BrIN4OS
![Methyl 4-[({[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}carbothioyl)amino]benzoate chemical structure, C15H15BrN4O3S, CAS 512807-32-8](/s/ZFJAXQZXOUWQPC-UHFFFAOYSA-N.svg)
Methyl 4-[({[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}carbothioyl)amino]benzoate
CAS 512807-32-8C15H15BrN4O3S
![N-(2-Bromophenyl)-N'-[(4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]thiourea chemical structure, C13H12BrClN4OS, CAS 515873-27-5](/s/ZHRTZKGKXNCRJU-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-N'-[(4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]thiourea
CAS 515873-27-5C13H12BrClN4OS
![4-Chloro-2-ethyl-N-[(2-iodophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C13H12ClIN4OS, CAS 494218-44-9](/s/DNKVDODOVRVGDK-UHFFFAOYSA-N.svg)
4-Chloro-2-ethyl-N-[(2-iodophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 494218-44-9C13H12ClIN4OS
![4-Chloro-2-ethyl-N-[(4-iodophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C13H12ClIN4OS, CAS 494218-47-2](/s/LQWNSNIVLIDGQW-UHFFFAOYSA-N.svg)
4-Chloro-2-ethyl-N-[(4-iodophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 494218-47-2C13H12ClIN4OS
![4-Chloro-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide chemical structure, C14H14ClIN4OS, CAS 494218-77-8](/s/BAYAOWAGNMTNPO-UHFFFAOYSA-N.svg)
4-Chloro-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide
CAS 494218-77-8C14H14ClIN4OS
![4-Bromo-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide chemical structure, C14H14BrIN4OS, CAS 494219-12-4](/s/MPHDNQDCQPHWMA-UHFFFAOYSA-N.svg)
4-Bromo-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide
CAS 494219-12-4C14H14BrIN4OS
![4-Chloro-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2-methylpyrazole-3-carboxamide chemical structure, C13H12ClIN4OS, CAS 512807-55-5](/s/PKWNXYSDHGCWOP-UHFFFAOYSA-N.svg)
4-Chloro-N-[(4-iodo-2-methylphenyl)carbamothioyl]-2-methylpyrazole-3-carboxamide
CAS 512807-55-5C13H12ClIN4OS
![4-Chloro-2-methyl-N-[(2-methyl-5-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C13H12ClN5O3S, CAS 512807-43-1](/s/GXQCDJJDAQXIMD-UHFFFAOYSA-N.svg)
4-Chloro-2-methyl-N-[(2-methyl-5-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 512807-43-1C13H12ClN5O3S
![4-Bromo-N-[(2-bromophenyl)carbamothioyl]-1-ethylpyrazole-3-carboxamide chemical structure, C13H12Br2N4OS, CAS 492425-56-6](/s/KAQUHFLMCRZQGK-UHFFFAOYSA-N.svg)
4-Bromo-N-[(2-bromophenyl)carbamothioyl]-1-ethylpyrazole-3-carboxamide
CAS 492425-56-6C13H12Br2N4OS
![N-[(4-Acetylphenyl)carbamothioyl]-4-bromo-1-ethylpyrazole-3-carboxamide chemical structure, C15H15BrN4O2S, CAS 492425-69-1](/s/OCAXOEITFRVWGY-UHFFFAOYSA-N.svg)
N-[(4-Acetylphenyl)carbamothioyl]-4-bromo-1-ethylpyrazole-3-carboxamide
CAS 492425-69-1C15H15BrN4O2S
![Ethyl 4-[({[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}carbothioyl)amino]benzoate chemical structure, C16H17BrN4O3S, CAS 512807-29-3](/s/PVEJQQFPPGWFLD-UHFFFAOYSA-N.svg)
Ethyl 4-[({[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}carbothioyl)amino]benzoate
CAS 512807-29-3C16H17BrN4O3S
![N-[(2-Bromo-4-methylphenyl)carbamothioyl]-4-chloro-2,5-dimethylpyrazole-3-carboxamide chemical structure, C14H14BrClN4OS, CAS 494218-52-9](/s/MTGVMFWQTHGEQR-UHFFFAOYSA-N.svg)
N-[(2-Bromo-4-methylphenyl)carbamothioyl]-4-chloro-2,5-dimethylpyrazole-3-carboxamide
CAS 494218-52-9C14H14BrClN4OS
![4-Chloro-N-[(4-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide chemical structure, C13H12ClIN4OS, CAS 494218-53-0](/s/VEGFBXSMWVGZTP-UHFFFAOYSA-N.svg)
4-Chloro-N-[(4-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide
CAS 494218-53-0C13H12ClIN4OS
![N-(4-Acetylphenyl)-N'-[(4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]thiourea chemical structure, C15H15ClN4O2S, CAS 494219-41-9](/s/SWTNIWJSQVINFJ-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-N'-[(4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]thiourea
CAS 494219-41-9C15H15ClN4O2S
![4-Chloro-N-[(2-chlorophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide chemical structure, C13H12Cl2N4OS, CAS 494219-47-5](/s/IDJIMBRFAPOPQL-UHFFFAOYSA-N.svg)
4-Chloro-N-[(2-chlorophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide
CAS 494219-47-5C13H12Cl2N4OS
![4-Bromo-1-ethyl-N-[(2-methyl-5-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide chemical structure, C14H14BrN5O3S, CAS 494745-80-1](/s/LGWRKINMRCFORY-UHFFFAOYSA-N.svg)
4-Bromo-1-ethyl-N-[(2-methyl-5-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide
CAS 494745-80-1C14H14BrN5O3S
![Butyl 4-[({[(4-chloro-1-ethyl-1H-pyrazol-5-yl)carbonyl]amino}carbothioyl)amino]benzoate chemical structure, C18H21ClN4O3S, CAS 494218-37-0](/s/FATHZHDEYWSUIL-UHFFFAOYSA-N.svg)
Butyl 4-[({[(4-chloro-1-ethyl-1H-pyrazol-5-yl)carbonyl]amino}carbothioyl)amino]benzoate
CAS 494218-37-0C18H21ClN4O3S
![4-Bromo-N-[(2-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide chemical structure, C13H12BrIN4OS, CAS 494219-86-2](/s/IFVZDHGLGVEVFO-UHFFFAOYSA-N.svg)
4-Bromo-N-[(2-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide
CAS 494219-86-2C13H12BrIN4OS
- Butyl 4-[({[(4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}carbothioyl)amino]benzoate494219-97-5C18H21BrN4O3S
- Butyl 4-[({[(4-chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}carbothioyl)amino]benzoate512808-29-6C17H19ClN4O3S
- Ethyl 4-[(4-chloro-2,5-dimethylpyrazole-3-carbonyl)carbamothioylamino]benzoate494218-78-9C16H17ClN4O3S
- 4-Bromo-1-ethyl-N-[(4-methoxyphenyl)carbamothioyl]pyrazole-3-carboxamide492425-74-8C14H15BrN4O2S
- 4-Bromo-1-ethyl-N-[(2-methoxyphenyl)carbamothioyl]pyrazole-3-carboxamide492425-73-7C14H15BrN4O2S
- 4-Bromo-N-[(2-bromo-4-methylphenyl)carbamothioyl]-1-ethylpyrazole-3-carboxamide492425-67-9C14H14Br2N4OS
- 4-Chloro-N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494746-48-4C13H11Cl2N5O4S
- 4-Bromo-N-[(2,4-dimethyl-6-nitrophenyl)carbamothioyl]-1-ethylpyrazole-3-carboxamide512807-31-7C15H16BrN5O3S
- 4-Chloro-2-ethyl-N-[(2-methyl-5-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide494746-43-9C14H14ClN5O3S
- 4-Chloro-N-[(4-methoxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494218-98-3C14H15ClN4O2S
- Methyl 4-[(4-bromo-2,5-dimethylpyrazole-3-carbonyl)carbamothioylamino]benzoate515874-45-0C15H15BrN4O3S
- 4-Chloro-N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]-2-ethylpyrazole-3-carboxamide496834-34-5C13H11Cl2N5O4S
- 4-Chloro-N-[(4-chloro-2-nitrophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494746-37-1C13H11Cl2N5O3S
- 4-Chloro-2,5-dimethyl-N-[(4-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide494746-31-5C13H12ClN5O3S
- 4-Chloro-2,5-dimethyl-N-[(2-nitrophenyl)carbamothioyl]pyrazole-3-carboxamide515874-50-7C13H12ClN5O3S
- 4-Chloro-N-[(2-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494218-89-2C13H12ClIN4OS
- N-[(4-Acetylphenyl)carbamothioyl]-4-bromo-2,5-dimethylpyrazole-3-carboxamide494219-05-5C15H15BrN4O2S
- 4-Bromo-N-[(4-iodophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494219-70-4C13H12BrIN4OS
- 4-Bromo-N-[(2-methoxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494219-64-6C14H15BrN4O2S
- 4-Chloro-N-[(3-hydroxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide494219-29-3C13H13ClN4O2S
- 4-Chloro-N-[(2,5-dimethoxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide512807-36-2C15H17ClN4O3S
- 4-Chloro-N-[(2-methoxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide515873-30-0C14H15ClN4O2S
- 4-Bromo-N-[(4-ethoxy-2-nitrophenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide496834-46-9C15H16BrN5O4S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
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