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Murcko scaffold

Ring system with 3 rings and 20 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
35
With full pages
8
Scaffold SMILES

O=C(Nc1ccccc1)c1cc(-c2ccccc2)n[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cc(-c2ccccc2)n[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

1H-Pyrazole-3-carboxamide, 5-(4-methoxyphenyl)-N-phenyl- chemical structure, C17H15N3O2, CAS 116341-61-8
1H-Pyrazole-3-carboxamide, 5-(4-methoxyphenyl)-N-phenyl-
CAS 116341-61-8C17H15N3O2
N-[4-(Acetylamino)phenyl]-5-(2-hydroxy-3,5-dimethylphenyl)-1H-pyrazole-3-carboxamide chemical structure, C20H20N4O3, CAS 879448-99-4
N-[4-(Acetylamino)phenyl]-5-(2-hydroxy-3,5-dimethylphenyl)-1H-pyrazole-3-carboxamide
CAS 879448-99-4C20H20N4O3
5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamide chemical structure, C16H14N4O4S, CAS 1886991-89-4
5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamide
CAS 1886991-89-4C16H14N4O4S
3-(5-Chloro-2-hydroxyphenyl)-N-(2,4-dimethoxyphenyl)-1H-pyrazole-5-carboxamide chemical structure, C18H16ClN3O4, CAS 879767-77-8
3-(5-Chloro-2-hydroxyphenyl)-N-(2,4-dimethoxyphenyl)-1H-pyrazole-5-carboxamide
CAS 879767-77-8C18H16ClN3O4
N-(5-Chloro-2-methoxyphenyl)-3-(2-hydroxy-3,4-dimethylphenyl)-1H-pyrazole-5-carboxamide chemical structure, C19H18ClN3O3, CAS 879447-91-3
N-(5-Chloro-2-methoxyphenyl)-3-(2-hydroxy-3,4-dimethylphenyl)-1H-pyrazole-5-carboxamide
CAS 879447-91-3C19H18ClN3O3
N-(2,5-Dimethylphenyl)-3-(2-hydroxy-4,5-dimethylphenyl)-1H-pyrazole-5-carboxamide chemical structure, C20H21N3O2, CAS 879445-08-6
N-(2,5-Dimethylphenyl)-3-(2-hydroxy-4,5-dimethylphenyl)-1H-pyrazole-5-carboxamide
CAS 879445-08-6C20H21N3O2
(5E)-N-(4-Acetamidophenyl)-5-(4,5-dimethyl-6-oxocyclohexa-2,4-dien-1-ylidene)-1,2-dihydropyrazole-3-carboxamide chemical structure, C20H20N4O3, CAS 1095941-38-0
(5E)-N-(4-Acetamidophenyl)-5-(4,5-dimethyl-6-oxocyclohexa-2,4-dien-1-ylidene)-1,2-dihydropyrazole-3-carboxamide
CAS 1095941-38-0C20H20N4O3
N-(3,4-Dimethylphenyl)-5-(2-hydroxy-4,5-dimethylphenyl)-1H-pyrazole-3-carboxamide chemical structure, C20H21N3O2, CAS 879457-90-6
N-(3,4-Dimethylphenyl)-5-(2-hydroxy-4,5-dimethylphenyl)-1H-pyrazole-3-carboxamide
CAS 879457-90-6C20H21N3O2
N-(3-Chloro-4-methoxyphenyl)-5-(2-hydroxyphenyl)-1H-pyrazole-3-carboxamide chemical structure, C17H14ClN3O3, CAS 879440-84-3
N-(3-Chloro-4-methoxyphenyl)-5-(2-hydroxyphenyl)-1H-pyrazole-3-carboxamide
CAS 879440-84-3C17H14ClN3O3
N-(2,4-Dimethoxyphenyl)-3-(2-hydroxy-4-methylphenyl)-1H-pyrazole-5-carboxamide chemical structure, C19H19N3O4, CAS 879579-53-0
N-(2,4-Dimethoxyphenyl)-3-(2-hydroxy-4-methylphenyl)-1H-pyrazole-5-carboxamide
CAS 879579-53-0C19H19N3O4
N-(4-Methoxyphenyl)-5-phenyl-1H-pyrazole-3-carboxamide chemical structure, C17H15N3O2, CAS 392728-13-1
N-(4-Methoxyphenyl)-5-phenyl-1H-pyrazole-3-carboxamide
CAS 392728-13-1C17H15N3O2
N-(2-Chloro-4-methylphenyl)-5-(4-fluorophenyl)-1H-pyrazole-3-carboxamide chemical structure, C17H13ClFN3O, CAS 2319066-87-8
N-(2-Chloro-4-methylphenyl)-5-(4-fluorophenyl)-1H-pyrazole-3-carboxamide
CAS 2319066-87-8C17H13ClFN3O
N-(2-Methoxy-5-(trifluoromethyl)phenyl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide chemical structure, C19H16F3N3O2, CAS 1206992-31-5
N-(2-Methoxy-5-(trifluoromethyl)phenyl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide
CAS 1206992-31-5C19H16F3N3O2
3-(4-Fluorophenyl)-1-methyl-N-(3-(methylsulfonamido)phenyl)-1H-pyrazole-5-carboxamide chemical structure, C18H17FN4O3S, CAS 1203006-50-1
3-(4-Fluorophenyl)-1-methyl-N-(3-(methylsulfonamido)phenyl)-1H-pyrazole-5-carboxamide
CAS 1203006-50-1C18H17FN4O3S
N-(3-(Difluoromethoxy)phenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamide chemical structure, C18H15F2N3O3, CAS 1239733-80-2
N-(3-(Difluoromethoxy)phenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamide
CAS 1239733-80-2C18H15F2N3O3
N-(3,4-Difluorophenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C18H15F2N3O2, CAS 1193233-98-5
N-(3,4-Difluorophenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS 1193233-98-5C18H15F2N3O2
5-(2-Chlorophenyl)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide chemical structure, C17H11ClF3N3O, CAS 1291014-76-0
5-(2-Chlorophenyl)-N-(4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxamide
CAS 1291014-76-0C17H11ClF3N3O
N-(3-Acetylphenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C20H19N3O3, CAS 1219901-76-4
N-(3-Acetylphenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS 1219901-76-4C20H19N3O3
Ethyl 4-(3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamido)benzoate chemical structure, C21H21N3O4, CAS 1219845-23-4
Ethyl 4-(3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamido)benzoate
CAS 1219845-23-4C21H21N3O4
N-(2-Carbamoylphenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C19H18N4O3, CAS 1219913-03-7
N-(2-Carbamoylphenyl)-3-(3-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS 1219913-03-7C19H18N4O3
N-(2-Aminophenyl)-3-phenyl-1H-pyrazole-5-carboxamide chemical structure, C16H14N4O, CAS 881214-31-9
N-(2-Aminophenyl)-3-phenyl-1H-pyrazole-5-carboxamide
CAS 881214-31-9C16H14N4O
1-Methyl-3-phenyl-N-(3,4,5-trifluorophenyl)-1H-pyrazole-5-carboxamide chemical structure, C17H12F3N3O, CAS 1374535-39-3
1-Methyl-3-phenyl-N-(3,4,5-trifluorophenyl)-1H-pyrazole-5-carboxamide
CAS 1374535-39-3C17H12F3N3O
3-(3-Chlorophenyl)-N-(2,4-dimethoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C19H18ClN3O3, CAS 1374545-72-8
3-(3-Chlorophenyl)-N-(2,4-dimethoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide
CAS 1374545-72-8C19H18ClN3O3
Methyl 4-({[3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)benzoate chemical structure, C19H16ClN3O3, CAS 1374541-84-0
Methyl 4-({[3-(2-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)benzoate
CAS 1374541-84-0C19H16ClN3O3