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Murcko scaffold

Ring system with 3 rings and 20 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
24
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)C1C=NN(c2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)C1C=NN(c2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone chemical structure, C17H14N2O2, CAS 4551-69-3
1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone
CAS 4551-69-3C17H14N2O2
5-Methyl-4-(4-nitrobenzoyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13N3O4, CAS 66755-21-3
5-Methyl-4-(4-nitrobenzoyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 66755-21-3C17H13N3O4
3-Methyl-4-(4-methylbenzoyl)-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C18H16N2O2, CAS 73087-92-0
3-Methyl-4-(4-methylbenzoyl)-1-phenyl-1H-pyrazol-5(4H)-one
CAS 73087-92-0C18H16N2O2
3H-Pyrazol-3-one, 4-(3,5-dinitrobenzoyl)-2,4-dihydro-5-methyl-2-phenyl- chemical structure, C17H12N4O6, CAS 66755-20-2
3H-Pyrazol-3-one, 4-(3,5-dinitrobenzoyl)-2,4-dihydro-5-methyl-2-phenyl-
CAS 66755-20-2C17H12N4O6
4-(4-Chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13ClN2O2, CAS 70692-01-2
4-(4-Chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 70692-01-2C17H13ClN2O2
4-(2-Chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13ClN2O2, CAS 73087-87-3
4-(2-Chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 73087-87-3C17H13ClN2O2
4-Benzoyl-2-phenyl-5-[(E)-prop-1-enyl]-4H-pyrazol-3-one chemical structure, C19H16N2O2
4-Benzoyl-2-phenyl-5-[(E)-prop-1-enyl]-4H-pyrazol-3-one
C19H16N2O2
3-Methyl-4-(2-methylbenzoyl)-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C18H16N2O2, CAS 73087-94-2
3-Methyl-4-(2-methylbenzoyl)-1-phenyl-1H-pyrazol-5(4H)-one
CAS 73087-94-2C18H16N2O2
4-(3,4-Dimethylbenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C19H18N2O2, CAS 1021108-02-0
4-(3,4-Dimethylbenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021108-02-0C19H18N2O2
4-(3,4-Dimethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C19H18N2O4, CAS 1021137-12-1
4-(3,4-Dimethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021137-12-1C19H18N2O4
4-(3-Fluorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C17H13FN2O2, CAS 129228-83-7
4-(3-Fluorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 129228-83-7C17H13FN2O2
4-(3,4-Difluorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C17H12F2N2O2, CAS 1021026-93-6
4-(3,4-Difluorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021026-93-6C17H12F2N2O2
3-Methyl-1-phenyl-4-(4-(trifluoromethyl)benzoyl)-1H-pyrazol-5(4H)-one chemical structure, C18H13F3N2O2, CAS 1021062-43-0
3-Methyl-1-phenyl-4-(4-(trifluoromethyl)benzoyl)-1H-pyrazol-5(4H)-one
CAS 1021062-43-0C18H13F3N2O2
4-(3-Chlorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C17H13ClN2O2, CAS 78666-11-2
4-(3-Chlorobenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 78666-11-2C17H13ClN2O2
4-(2,4-Dimethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C19H18N2O4, CAS 1021108-05-3
4-(2,4-Dimethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021108-05-3C19H18N2O4
4-(4-Ethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C19H18N2O3, CAS 1021137-14-3
4-(4-Ethoxybenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021137-14-3C19H18N2O3
4-(3,5-Dimethylbenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one chemical structure, C19H18N2O2, CAS 1021026-94-7
4-(3,5-Dimethylbenzoyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
CAS 1021026-94-7C19H18N2O2
N,N-Dimethyl-4-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4-carbonyl)benzenesulfonamide chemical structure, C19H19N3O4S, CAS 1021137-17-6
N,N-Dimethyl-4-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-4-carbonyl)benzenesulfonamide
CAS 1021137-17-6C19H19N3O4S
5-Methyl-4-(4-methylbenzoyl)-2-p-tolyl-2,4-dihydro-3H-pyrazole-3-one chemical structure, C19H18N2O2, CAS 1009618-72-7
5-Methyl-4-(4-methylbenzoyl)-2-p-tolyl-2,4-dihydro-3H-pyrazole-3-one
CAS 1009618-72-7C19H18N2O2
4-(2,3-Dinitrobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H12N4O6, CAS 88898-01-5
4-(2,3-Dinitrobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 88898-01-5C17H12N4O6
4-(2-Fluorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13FN2O2, CAS 129228-92-8
4-(2-Fluorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 129228-92-8C17H13FN2O2
5-Methyl-4-(3-methylbenzoyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C18H16N2O2, CAS 73087-93-1
5-Methyl-4-(3-methylbenzoyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
CAS 73087-93-1C18H16N2O2
4-Benzoyl-2-phenyl-5-(prop-1-en-1-yl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H16N2O2, CAS 88075-58-5
4-Benzoyl-2-phenyl-5-(prop-1-en-1-yl)-2,4-dihydro-3H-pyrazol-3-one
CAS 88075-58-5C19H16N2O2
4-Benzoyl-2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13ClN2O2, CAS 125670-60-2
4-Benzoyl-2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 125670-60-2C17H13ClN2O2