Murcko scaffold
Ring system with 3 rings and 23 atoms
56 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 56
- With full pages
- 4
Scaffold SMILES
O=C(Nc1ccccc1)c1ccc(NCc2ccccc2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 56 chemicals
![N-(2-Bromophenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C22H21BrN2O3S, CAS 663164-31-6](/s/POWGWOJFWNZKFK-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 663164-31-6C22H21BrN2O3S
![4-[(2-Chlorobenzyl)(methylsulfonyl)amino]-N-(2-ethyl-6-methylphenyl)benzamide chemical structure, C24H25ClN2O3S, CAS 592472-69-0](/s/MHYMRNQQUQKSBC-UHFFFAOYSA-N.svg)
4-[(2-Chlorobenzyl)(methylsulfonyl)amino]-N-(2-ethyl-6-methylphenyl)benzamide
CAS 592472-69-0C24H25ClN2O3S
![Ethyl 4-({4-[(2-chlorobenzyl)(methylsulfonyl)amino]benzoyl}amino)benzoate chemical structure, C24H23ClN2O5S, CAS 433235-76-8](/s/YOBFKCJSQRDVAN-UHFFFAOYSA-N.svg)
Ethyl 4-({4-[(2-chlorobenzyl)(methylsulfonyl)amino]benzoyl}amino)benzoate
CAS 433235-76-8C24H23ClN2O5S
![Methyl 4-methyl-3-({4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl}amino)benzoate chemical structure, C25H26N2O5S, CAS 643003-85-4](/s/UMFCDOMQCMTXDN-UHFFFAOYSA-N.svg)
Methyl 4-methyl-3-({4-[(2-methylbenzyl)(methylsulfonyl)amino]benzoyl}amino)benzoate
CAS 643003-85-4C25H26N2O5S
![N-[4-(Acetylamino)phenyl]-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C24H25N3O4S, CAS 640717-20-0](/s/QACXUSZAFGNSJD-UHFFFAOYSA-N.svg)
N-[4-(Acetylamino)phenyl]-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 640717-20-0C24H25N3O4S
![N-(5-Chloro-2-methylphenyl)-4-[(methylsulfonyl)(phenylmethyl)amino]benzamide chemical structure, C22H21ClN2O3S, CAS 357328-87-1](/s/MQVWCALHBVXTII-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methylphenyl)-4-[(methylsulfonyl)(phenylmethyl)amino]benzamide
CAS 357328-87-1C22H21ClN2O3S
![4-[(4-Chlorobenzyl)(methylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide chemical structure, C23H23ClN2O4S, CAS 363145-57-7](/s/JFQMBSQORHLLPC-UHFFFAOYSA-N.svg)
4-[(4-Chlorobenzyl)(methylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
CAS 363145-57-7C23H23ClN2O4S
![4-[(4-Chlorophenyl)methyl-methylsulfonylamino]-N-(2,6-dimethylphenyl)benzamide chemical structure, C23H23ClN2O3S, CAS 425417-12-5](/s/JEHFGYBEZIQRME-UHFFFAOYSA-N.svg)
4-[(4-Chlorophenyl)methyl-methylsulfonylamino]-N-(2,6-dimethylphenyl)benzamide
CAS 425417-12-5C23H23ClN2O3S
![N-(2-Bromophenyl)-4-[(4-chlorophenyl)methyl-methylsulfonylamino]benzamide chemical structure, C21H18BrClN2O3S, CAS 425608-68-0](/s/VOBTUQMMNSMONL-UHFFFAOYSA-N.svg)
N-(2-Bromophenyl)-4-[(4-chlorophenyl)methyl-methylsulfonylamino]benzamide
CAS 425608-68-0C21H18BrClN2O3S
![4-[Benzyl(methylsulfonyl)amino]-N-(2-methoxyphenyl)benzamide chemical structure, C22H22N2O4S, CAS 333356-84-6](/s/SYFHFMAHMAUQAK-UHFFFAOYSA-N.svg)
4-[Benzyl(methylsulfonyl)amino]-N-(2-methoxyphenyl)benzamide
CAS 333356-84-6C22H22N2O4S
![4-[Benzyl(methylsulfonyl)amino]-N-(4-methoxyphenyl)benzamide chemical structure, C22H22N2O4S, CAS 333356-86-8](/s/HLFZGAPMWHEHSJ-UHFFFAOYSA-N.svg)
4-[Benzyl(methylsulfonyl)amino]-N-(4-methoxyphenyl)benzamide
CAS 333356-86-8C22H22N2O4S
![4-[Benzyl(methylsulfonyl)amino]-N-(4-ethoxyphenyl)benzamide chemical structure, C23H24N2O4S, CAS 333356-87-9](/s/BULZVSNHCSGLJJ-UHFFFAOYSA-N.svg)
4-[Benzyl(methylsulfonyl)amino]-N-(4-ethoxyphenyl)benzamide
CAS 333356-87-9C23H24N2O4S
![4-[Benzyl(methylsulfonyl)amino]-N-[4-(cyanomethyl)phenyl]benzamide chemical structure, C23H21N3O3S, CAS 332034-50-1](/s/JRPJPZAIBOCUCI-UHFFFAOYSA-N.svg)
4-[Benzyl(methylsulfonyl)amino]-N-[4-(cyanomethyl)phenyl]benzamide
CAS 332034-50-1C23H21N3O3S
![4-[(4-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-methoxyphenyl)benzamide chemical structure, C22H21ClN2O4S, CAS 357390-77-3](/s/XRSSBUCJXVNOIN-UHFFFAOYSA-N.svg)
4-[(4-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-methoxyphenyl)benzamide
CAS 357390-77-3C22H21ClN2O4S
![N-(4-Acetylphenyl)-4-[(4-chlorobenzyl)(methylsulfonyl)amino]benzamide chemical structure, C23H21ClN2O4S, CAS 357390-82-0](/s/NMUUOWNSCMHTHI-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-4-[(4-chlorobenzyl)(methylsulfonyl)amino]benzamide
CAS 357390-82-0C23H21ClN2O4S
![4-[(4-Chlorobenzyl)(methylsulfonyl)amino]-N-(3-methoxyphenyl)benzamide chemical structure, C22H21ClN2O4S, CAS 357390-76-2](/s/UWXBIICEINFCLN-UHFFFAOYSA-N.svg)
4-[(4-Chlorobenzyl)(methylsulfonyl)amino]-N-(3-methoxyphenyl)benzamide
CAS 357390-76-2C22H21ClN2O4S
![N-(2-Ethylphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C24H26N2O3S, CAS 664320-22-3](/s/UOBKHFSVDJOZOC-UHFFFAOYSA-N.svg)
N-(2-Ethylphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 664320-22-3C24H26N2O3S
![N-(2,4-Difluorophenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C22H20F2N2O3S, CAS 461645-95-4](/s/ASIYUPULQWMPOP-UHFFFAOYSA-N.svg)
N-(2,4-Difluorophenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 461645-95-4C22H20F2N2O3S
![2-[[4-[(2-Chlorophenyl)methyl-methylsulfonylamino]benzoyl]amino]-N-propan-2-ylbenzamide chemical structure, C25H26ClN3O4S, CAS 592472-67-8](/s/WJQBAXUVFKQFEZ-UHFFFAOYSA-N.svg)
2-[[4-[(2-Chlorophenyl)methyl-methylsulfonylamino]benzoyl]amino]-N-propan-2-ylbenzamide
CAS 592472-67-8C25H26ClN3O4S
![N-(5-Chloro-2-methoxyphenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C23H23ClN2O4S, CAS 529499-91-0](/s/MHKDYJWCGKGLLW-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methoxyphenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 529499-91-0C23H23ClN2O4S
![N-(4-Methoxyphenyl)-4-[(4-methylphenyl)methyl-methylsulfonylamino]benzamide chemical structure, C23H24N2O4S, CAS 532408-81-4](/s/DHFCNWGBEVFZFR-UHFFFAOYSA-N.svg)
N-(4-Methoxyphenyl)-4-[(4-methylphenyl)methyl-methylsulfonylamino]benzamide
CAS 532408-81-4C23H24N2O4S
![N-(3-Chloro-4-methoxyphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C23H23ClN2O4S, CAS 694487-09-7](/s/IVVBIOFOSADOLX-UHFFFAOYSA-N.svg)
N-(3-Chloro-4-methoxyphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 694487-09-7C23H23ClN2O4S
![N-(4-Chloro-2-methylphenyl)-4-[(2-methylphenyl)methyl-methylsulfonylamino]benzamide chemical structure, C23H23ClN2O3S, CAS 643006-35-3](/s/KVFHKFQGIUITAC-UHFFFAOYSA-N.svg)
N-(4-Chloro-2-methylphenyl)-4-[(2-methylphenyl)methyl-methylsulfonylamino]benzamide
CAS 643006-35-3C23H23ClN2O3S
![N-(4-Bromo-3-methylphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide chemical structure, C23H23BrN2O3S, CAS 694499-13-3](/s/GWLODQNDUDIORI-UHFFFAOYSA-N.svg)
N-(4-Bromo-3-methylphenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide
CAS 694499-13-3C23H23BrN2O3S
- N-(4-Fluorophenyl)-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide694501-05-8C22H21FN2O3S
- N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-[(2-methylbenzyl)(methylsulfonyl)amino]benzamide694501-23-0C23H20ClF3N2O3S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(2-methoxyphenyl)benzamide461445-62-5C22H21ClN2O4S
- 4-[Benzyl(methylsulfonyl)amino]-N-(3-methylsulfanylphenyl)benzamide591731-74-7C22H22N2O3S2
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-fluorophenyl)benzamide432509-04-1C21H18ClFN2O3S
- N-(3,4-Dimethoxyphenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide462062-24-4C24H26N2O5S
- N-(4-Methoxyphenyl)-4-[(2-methylphenyl)methyl-methylsulfonylamino]benzamide693811-76-6C23H24N2O4S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(2-ethoxyphenyl)benzamide431980-28-8C23H23ClN2O4S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-ethoxyphenyl)benzamide432494-72-9C23H23ClN2O4S
- 4-[(4-Chlorophenyl)methyl-methylsulfonylamino]-N-(2,3-dimethylphenyl)benzamide462088-86-4C23H23ClN2O3S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(3-methylphenyl)benzamide432496-54-3C22H21ClN2O3S
- 2-[[4-[Benzyl(methylsulfonyl)amino]benzoyl]amino]benzamide531520-67-9C22H21N3O4S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(2,4-dimethoxyphenyl)benzamide433232-35-0C23H23ClN2O5S
- N-(3-Chloro-4-methoxyphenyl)-4-[(4-methylphenyl)methyl-methylsulfonylamino]benzamide530095-58-0C23H23ClN2O4S
- N-(2,4-Dimethylphenyl)-4-[(4-methylbenzyl)(methylsulfonyl)amino]benzamide528833-97-8C24H26N2O3S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(3-methoxyphenyl)benzamide432001-71-3C22H21ClN2O4S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-methoxyphenyl)benzamide432008-04-3C22H21ClN2O4S
- 4-[(2-Chlorobenzyl)(methylsulfonyl)amino]-N-(3-chloro-4-methoxyphenyl)benzamide431925-91-6C22H20Cl2N2O4S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(3,5-dimethylphenyl)benzamide431994-56-8C23H23ClN2O3S
- N-(3-Bromophenyl)-4-[(2-chlorophenyl)methyl-methylsulfonylamino]benzamide431995-12-9C21H18BrClN2O3S
- 4-[(2-Chlorophenyl)methyl-methylsulfonylamino]-N-(4-propan-2-ylphenyl)benzamide431996-89-3C24H25ClN2O3S
- 2-[({4-[(4-Chlorobenzyl)(methylsulfonyl)amino]phenyl}carbonyl)amino]benzoic acid527692-70-2C22H19ClN2O5S
- 2-{4-[Benzyl(methanesulfonyl)amino]benzamido}benzoic acid6461-48-9C22H20N2O5S
- 4-[Benzyl(methylsulfonyl)amino]-N-(4-chloro-2-methylphenyl)benzamide5733-80-2C22H21ClN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1)c1ccccc137 chemicals
O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1)c1ccccc119 chemicals
O=C(Nc1ccccc1)c1ccc(C(=O)Nc2ccccc2)cc119 chemicals
c1ccc(N=Nc2ccc(N=Nc3ccccc3)cc2)cc118 chemicals
O=C(Nc1ccc(NC(=O)c2ccccc2)cc1)c1ccccc116 chemicals
C(=Nc1ccc(N=Cc2ccccc2)cc1)c1ccccc116 chemicals
C(=Nc1ccccc1)c1ccc(C=Nc2ccccc2)cc116 chemicals
O=C(Oc1coc(CSc2ncccn2)cc1=O)c1ccccc113 chemicals
C(=Cc1ccc(C=Cc2ccccc2)cc1)c1ccccc112 chemicals
O=C(Oc1ccc(C(=O)Oc2ccccc2)cc1)c1ccccc112 chemicals
C(=Nc1ccccc1)c1ccc(OCc2ccccc2)cc111 chemicals
O=C(Nc1ccc(N=Nc2ccccc2)cc1)c1ccccc110 chemicals