Murcko scaffold
Ring system with 4 rings and 20 atoms
35 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 20
- Chemicals
- 35
- With full pages
- 13
Scaffold SMILES
C(=C1CCc2cc3ccccc3nc21)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 35 of 35 chemicals
![3-[(2-Chlorophenyl)methylene]-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C20H14ClNO2, CAS 379729-50-7](/s/DBLZUTWTBPGNJZ-UHFFFAOYSA-N.svg)
3-[(2-Chlorophenyl)methylene]-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 379729-50-7C20H14ClNO2
![3-[[2-(Carboxymethoxy)phenyl]methylene]-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H17NO5](/s/KMYUIROGSMBLNN-UHFFFAOYSA-N.svg)
3-[[2-(Carboxymethoxy)phenyl]methylene]-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid
C22H17NO5
![3-[(4-Hydroxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid chemical structure, C20H15NO3](/s/RLRNPHISVAQKAJ-UHFFFAOYSA-N.svg)
3-[(4-Hydroxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid
C20H15NO3
![3-[(2,3-Dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H19NO4](/s/BPQVIKMJNIHOPM-UHFFFAOYSA-N.svg)
3-[(2,3-Dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
C22H19NO4
![3-[(4-Chlorophenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C20H14ClNO2](/s/KVJSBURZPOBEQI-UHFFFAOYSA-N.svg)
3-[(4-Chlorophenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
C20H14ClNO2
2,3-Dihydro-3-(phenylmethylene)-1H-cyclopenta(b)quinoline-9-carboxylic acid
CAS 22311-74-6C20H15NO2
![3-[(2-Chloro-6-fluorophenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C20H13ClFNO2, CAS 380574-64-1](/s/GCWVEUXRHJDYRU-ZHACJKMWSA-N.svg)
3-[(2-Chloro-6-fluorophenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 380574-64-1C20H13ClFNO2
![(3Z)-3-[[2-(Carboxymethoxy)phenyl]methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H17NO5](/s/KMYUIROGSMBLNN-KAMYIIQDSA-N.svg)
(3Z)-3-[[2-(Carboxymethoxy)phenyl]methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid
C22H17NO5
![(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H19NO4](/s/BPQVIKMJNIHOPM-SEYXRHQNSA-N.svg)
(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid
C22H19NO4
Ebov-IN-C31
CAS 752216-12-9C26H25N3O6
![(3E)-3-[(4-Chlorophenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid chemical structure, C20H14ClNO2, CAS 522624-46-0](/s/KVJSBURZPOBEQI-ACCUITESSA-N.svg)
(3E)-3-[(4-Chlorophenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid
CAS 522624-46-0C20H14ClNO2
3-((3,4-Dichlorophenyl)methylidene)-1H,2H,3H-cyclopenta(b)quinoline-9-carboxylic acid
CAS 380574-48-1C20H13Cl2NO2
![3-[(3,4,5-Trimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C23H21NO5, CAS 380574-32-3](/s/KRBNMJWDYSYQPX-GXDHUFHOSA-N.svg)
3-[(3,4,5-Trimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 380574-32-3C23H21NO5
![3-[(4-tert-Butylphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C24H23NO2, CAS 647036-26-8](/s/HDOAWHDGWAGPFR-JQIJEIRASA-N.svg)
3-[(4-tert-Butylphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 647036-26-8C24H23NO2
![3-{[2-(Carboxymethoxy)phenyl]methylidene}-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H17NO5, CAS 722467-69-8](/s/KMYUIROGSMBLNN-SDNWHVSQSA-N.svg)
3-{[2-(Carboxymethoxy)phenyl]methylidene}-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 722467-69-8C22H17NO5
![(3E)-3-[(2,3-Dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H19NO4, CAS 750617-49-3](/s/BPQVIKMJNIHOPM-OUKQBFOZSA-N.svg)
(3E)-3-[(2,3-Dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylic acid
CAS 750617-49-3C22H19NO4
![3-[(3,4-Dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C22H19NO4, CAS 379726-67-7](/s/ITWSNYABEWGWGX-SDNWHVSQSA-N.svg)
3-[(3,4-Dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 379726-67-7C22H19NO4
![3-[(4-Methoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C21H17NO3, CAS 380342-11-0](/s/ZDXPPQLCLKFYBQ-WYMLVPIESA-N.svg)
3-[(4-Methoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 380342-11-0C21H17NO3
3-((4-Methylphenyl)methylidene)-1H,2H,3H-cyclopenta(b)quinoline-9-carboxylic acid
CAS 380574-24-3C21H17NO2
3-((4-(Dimethylamino)phenyl)methylidene)-1H,2H,3H-cyclopenta(b)quinoline-9-carboxylic acid
CAS 380574-56-1C22H20N2O2
![3-(4-Diethylamino-benzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid chemical structure, C24H24N2O2, CAS 726157-44-4](/s/CCZRNQOQPNJJIP-BMRADRMJSA-N.svg)
3-(4-Diethylamino-benzylidene)-2,3-dihydro-1H-cyclopenta[b]quinoline-9-carboxylic acid
CAS 726157-44-4C24H24N2O2
![(3Z)-3-Benzylidene-1,2-dihydrocyclopenta[b]quinoline chemical structure, C19H15N, CAS 32353-38-1](/s/YTSWLKWYRVTRMW-VBKFSLOCSA-N.svg)
(3Z)-3-Benzylidene-1,2-dihydrocyclopenta[b]quinoline
CAS 32353-38-1C19H15N
![(3Z)-3-Benzylidene-N-(cyanomethyl)-1,2-dihydrocyclopenta[b]quinoline-9-carboxamide chemical structure, C22H17N3O, CAS 1365644-76-3](/s/GWJZONFZWUFMJE-PEZBUJJGSA-N.svg)
(3Z)-3-Benzylidene-N-(cyanomethyl)-1,2-dihydrocyclopenta[b]quinoline-9-carboxamide
CAS 1365644-76-3C22H17N3O
![[1-(Ethylcarbamoylamino)-1-oxopropan-2-yl] (3E)-3-[(3,4-dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylate chemical structure, C28H29N3O6, CAS 1565845-92-2](/s/PHJQCMBFMOQNFF-NBVRZTHBSA-N.svg)
[1-(Ethylcarbamoylamino)-1-oxopropan-2-yl] (3E)-3-[(3,4-dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylate
CAS 1565845-92-2C28H29N3O6
- 3-[(4-Chlorophenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acidC20H14ClNO2
- N-(Cyanomethyl)-3-[(2,3-dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxamide1808659-15-5C24H21N3O3
- N-(Cyanomethyl)-N-ethyl-3-[(4-methoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxamide1808542-09-7C25H23N3O2
- 2-{3-[(3,4-Dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carbonyloxy}propanoic acid1807940-59-5C25H23NO6
- N-(1-Cyanoethyl)-3-(phenylmethylidene)-1H,2H,3H-cyclopenta[b]quinoline-9-carboxamide1808543-29-4C23H19N3O
- 3-[(4-Hydroxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acid748777-72-2C20H15NO3
- 3-[(4-Hydroxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylic acidC20H15NO3
- 1-[(Ethylcarbamoyl)amino]-1-oxopropan-2-yl (3Z)-3-[(3,4-dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxylateC28H29N3O6
- [1-(Ethylcarbamoylamino)-1-oxopropan-2-yl] 3-[(3,4-dimethoxyphenyl)methylidene]-1,2-dihydrocyclopenta[b]quinoline-9-carboxylateC28H29N3O6
- (3E)-N-(2-Aminoethyl)-3-[(3,4-dimethoxyphenyl)methylidene]-1H,2H,3H-cyclopenta[b]quinoline-9-carboxamide hydrochloride2639466-40-1C24H26ClN3O3
- N-(Cyanomethyl)-N-methyl-3-(phenylmethylidene)-1H,2H,3H-cyclopenta[b]quinoline-9-carboxamide1808883-97-7C23H19N3O
Related scaffolds
Same ring framework with different atoms or bond orders
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c1ccc(Cn2ccc3nc4ccccc4nc32)cc12 chemicals
O=c1c2ccn(Cc3ccccc3)c2nc2ccccn121 chemical
c1ccc(CN2CCc3cc4ccccc4nc32)cc11 chemical
O=C1c2ccccc2C(=O)c2c(C(=O)N3CCCCC3)coc211 chemical![Scaffold O=c1[nH]cnc2cc3c(cc12)C(Nc1ccccc1)CC3](/scaffold/XRYXHRSMGGJRJN-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cnc2cc3c(cc12)C(Nc1ccccc1)CC31 chemical