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Murcko scaffold

Ring system with 3 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
9
With full pages
0
Scaffold SMILES

O=c1c(C=NCc2cccnc2)c[nH]n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(C=NCc2cccnc2)c[nH]n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

(Z)-3-Methyl-1-phenyl-4-(((pyridin-3-ylmethyl)amino)methylene)-1H-pyrazol-5(4H)-one chemical structure, C17H16N4O, CAS 320425-14-7
(Z)-3-Methyl-1-phenyl-4-(((pyridin-3-ylmethyl)amino)methylene)-1H-pyrazol-5(4H)-one
CAS 320425-14-7C17H16N4O
2-{4-Nitrophenyl}-5-methyl-4-[N-(3-pyridinylmethyl)ethanimidoyl]-1,2-dihydro-3H-pyrazol-3-one chemical structure, C18H17N5O3, CAS 354543-05-8
2-{4-Nitrophenyl}-5-methyl-4-[N-(3-pyridinylmethyl)ethanimidoyl]-1,2-dihydro-3H-pyrazol-3-one
CAS 354543-05-8C18H17N5O3
5-Ethoxy-2-phenyl-4-{[(3-pyridinylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one chemical structure, C18H18N4O2, CAS 338751-01-2
5-Ethoxy-2-phenyl-4-{[(3-pyridinylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one
CAS 338751-01-2C18H18N4O2
2-(4-Chlorophenyl)-5-ethoxy-4-{[(3-pyridinylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one chemical structure, C18H17ClN4O2, CAS 338751-19-2
2-(4-Chlorophenyl)-5-ethoxy-4-{[(3-pyridinylmethyl)amino]methylene}-2,4-dihydro-3H-pyrazol-3-one
CAS 338751-19-2C18H17ClN4O2
2-Phenyl-4-{[(3-pyridinylmethyl)amino]methylene}-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C17H13F3N4O, CAS 477851-35-7
2-Phenyl-4-{[(3-pyridinylmethyl)amino]methylene}-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one
CAS 477851-35-7C17H13F3N4O
(4E)-2-(4-Nitrophenyl)-5-propyl-4-[(pyridin-3-ylmethylamino)methylidene]pyrazol-3-one chemical structure, C19H19N5O3, CAS 371939-00-3
(4E)-2-(4-Nitrophenyl)-5-propyl-4-[(pyridin-3-ylmethylamino)methylidene]pyrazol-3-one
CAS 371939-00-3C19H19N5O3
Methyl [(4Z)-5-oxo-1-phenyl-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-4,5-dihydro-1H-pyrazol-3-yl]acetate chemical structure, C20H20N4O3, CAS 1062624-79-6
Methyl [(4Z)-5-oxo-1-phenyl-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-4,5-dihydro-1H-pyrazol-3-yl]acetate
CAS 1062624-79-6C20H20N4O3
Methyl [(4Z)-1-(4-methoxyphenyl)-5-oxo-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-4,5-dihydro-1H-pyrazol-3-yl]acetate chemical structure, C21H22N4O4, CAS 879057-99-5
Methyl [(4Z)-1-(4-methoxyphenyl)-5-oxo-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-4,5-dihydro-1H-pyrazol-3-yl]acetate
CAS 879057-99-5C21H22N4O4
(4Z)-2-(4-Methoxyphenyl)-5-propyl-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-2,4-dihydro-3H-pyrazol-3-one chemical structure, C21H24N4O2, CAS 884412-71-9
(4Z)-2-(4-Methoxyphenyl)-5-propyl-4-{1-[(pyridin-3-ylmethyl)amino]ethylidene}-2,4-dihydro-3H-pyrazol-3-one
CAS 884412-71-9C21H24N4O2