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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,681 to 1,728 of 6,403 chemicals

1-(tert-Pentyloxy)-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride chemical structure, C19H30ClF3N2O2, CAS 1185554-92-0
1-(tert-Pentyloxy)-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1185554-92-0C19H30ClF3N2O2
1-Butoxy-3-(4-phenylpiperazin-1-yl)propan-2-ol dihydrochloride chemical structure, C17H30Cl2N2O2, CAS 1217110-26-3
1-Butoxy-3-(4-phenylpiperazin-1-yl)propan-2-ol dihydrochloride
CAS 1217110-26-3C17H30Cl2N2O2
1-Butoxy-3-(4-(4-methoxyphenyl)piperazin-1-yl)propan-2-ol dihydrochloride chemical structure, C18H32Cl2N2O3, CAS 1216852-91-3
1-Butoxy-3-(4-(4-methoxyphenyl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 1216852-91-3C18H32Cl2N2O3
1-Butoxy-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-ol dihydrochloride chemical structure, C18H32Cl2N2O3, CAS 1216629-65-0
1-Butoxy-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-ol dihydrochloride
CAS 1216629-65-0C18H32Cl2N2O3
1-Butoxy-3-[4-(4-fluorophenyl)piperazin-1-yl]propan-2-ol dihydrochloride chemical structure, C17H29Cl2FN2O2, CAS 1215647-50-9
1-Butoxy-3-[4-(4-fluorophenyl)piperazin-1-yl]propan-2-ol dihydrochloride
CAS 1215647-50-9C17H29Cl2FN2O2
1-Butoxy-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride chemical structure, C18H28ClF3N2O2, CAS 1217071-40-3
1-Butoxy-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1217071-40-3C18H28ClF3N2O2
N-{4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]phenyl}-3-methylbutanamide chemical structure, C20H31N3O2, CAS 895074-46-1
N-{4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]phenyl}-3-methylbutanamide
CAS 895074-46-1C20H31N3O2
N-{4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]phenyl}-2-methylpropanamide chemical structure, C19H29N3O2, CAS 895076-72-9
N-{4-[4-(2,2-Dimethylpropanoyl)piperazin-1-yl]phenyl}-2-methylpropanamide
CAS 895076-72-9C19H29N3O2
N-[3-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-3-methylbutanamide chemical structure, C19H28ClN3O2, CAS 916032-23-0
N-[3-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-3-methylbutanamide
CAS 916032-23-0C19H28ClN3O2
N-[3-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2,2-dimethylpropanamide chemical structure, C19H28ClN3O2, CAS 916032-14-9
N-[3-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2,2-dimethylpropanamide
CAS 916032-14-9C19H28ClN3O2
{4-[4-(Trifluoroacetyl)piperazin-1-yl]phenyl}amine chemical structure, C12H14F3N3O, CAS 193903-35-4
{4-[4-(Trifluoroacetyl)piperazin-1-yl]phenyl}amine
CAS 193903-35-4C12H14F3N3O
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}pentanamide chemical structure, C20H30ClN3O2, CAS 884451-69-8
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}pentanamide
CAS 884451-69-8C20H30ClN3O2
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}-2,2-dimethylpropanamide chemical structure, C20H30ClN3O2, CAS 884458-41-7
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}-2,2-dimethylpropanamide
CAS 884458-41-7C20H30ClN3O2
N-{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}-3-methylbutanamide chemical structure, C20H30ClN3O2, CAS 884471-43-6
N-{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}-3-methylbutanamide
CAS 884471-43-6C20H30ClN3O2
N-{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}butanamide chemical structure, C19H28ClN3O2, CAS 884476-21-5
N-{3-Chloro-4-[4-(3-methylbutanoyl)piperazin-1-yl]phenyl}butanamide
CAS 884476-21-5C19H28ClN3O2
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}butanamide chemical structure, C19H28ClN3O2, CAS 884477-13-8
N-{3-Chloro-4-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]phenyl}butanamide
CAS 884477-13-8C19H28ClN3O2
Ethyl 3-nitro-4-(piperazin-1-yl)benzoate chemical structure, C13H17N3O4, CAS 886631-29-4
Ethyl 3-nitro-4-(piperazin-1-yl)benzoate
CAS 886631-29-4C13H17N3O4
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]acetamide chemical structure, C16H22ClN3O2, CAS 895344-71-5
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]acetamide
CAS 895344-71-5C16H22ClN3O2
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]butanamide chemical structure, C18H26ClN3O2, CAS 895344-75-9
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]butanamide
CAS 895344-75-9C18H26ClN3O2
N-[5-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-3-methylbutanamide chemical structure, C19H28ClN3O2, CAS 895344-77-1
N-[5-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]-3-methylbutanamide
CAS 895344-77-1C19H28ClN3O2
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2-methylpropanamide chemical structure, C18H26ClN3O2, CAS 895344-79-3
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2-methylpropanamide
CAS 895344-79-3C18H26ClN3O2
N-[2-(4-Butyryl-1-piperazinyl)-5-chlorophenyl]acetamide chemical structure, C16H22ClN3O2, CAS 899156-08-2
N-[2-(4-Butyryl-1-piperazinyl)-5-chlorophenyl]acetamide
CAS 899156-08-2C16H22ClN3O2
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]butanamide chemical structure, C18H26ClN3O2, CAS 899127-93-6
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]butanamide
CAS 899127-93-6C18H26ClN3O2
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]pentanamide chemical structure, C19H28ClN3O2, CAS 899128-00-8
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]pentanamide
CAS 899128-00-8C19H28ClN3O2