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Murcko scaffold

1,2,3,4-Tetrahydro-1,8-naphthyridine scaffold

257 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
257
With full pages
38
Scaffold SMILES

c1cnc2c(c1)CCCN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydro-1,8-naphthyridine page
Murcko scaffold c1cnc2c(c1)CCCN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 241 to 257 of 257 chemicals

2-Methyl-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylic acid chemical structure, C12H11F3N2O3, CAS 2680753-10-8
2-Methyl-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylic acid
CAS 2680753-10-8C12H11F3N2O3
3-[2-Methyl-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl]propanoic acid chemical structure, C14H15F3N2O3, CAS 2680861-62-3
3-[2-Methyl-8-(2,2,2-trifluoroacetyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl]propanoic acid
CAS 2680861-62-3C14H15F3N2O3
1-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)methanamine dihydrochloride chemical structure, C9H15Cl2N3, CAS 2758006-25-4
1-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)methanamine dihydrochloride
CAS 2758006-25-4C9H15Cl2N3
4-{8-[(Prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}butanoic acid chemical structure, C16H20N2O4, CAS 2870659-65-5
4-{8-[(Prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}butanoic acid
CAS 2870659-65-5C16H20N2O4
3-{8-[(Prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}propanoic acid chemical structure, C15H18N2O4, CAS 2870645-50-2
3-{8-[(Prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}propanoic acid
CAS 2870645-50-2C15H18N2O4
3-{2-Methyl-8-[(prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl}propanoic acid chemical structure, C16H20N2O4, CAS 2913417-15-7
3-{2-Methyl-8-[(prop-2-en-1-yloxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl}propanoic acid
CAS 2913417-15-7C16H20N2O4
3-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C8H9FN2, CAS 2748552-06-7
3-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 2748552-06-7C8H9FN2
6-Bromo-3-fluoro-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C8H8BrFN2, CAS 2748579-39-5
6-Bromo-3-fluoro-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 2748579-39-5C8H8BrFN2
6-Bromo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-amine chemical structure, C8H10BrN3, CAS 2749753-46-4
6-Bromo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-amine
CAS 2749753-46-4C8H10BrN3
Methyl (S)-2-(Boc-amino)-4-[(2-methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoate chemical structure, C25H42N4O5
Methyl (S)-2-(Boc-amino)-4-[(2-methoxyethyl)[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl]amino]butanoate
C25H42N4O5
3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propanenitrile hydrochloride chemical structure, C11H14ClN3
3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propanenitrile hydrochloride
C11H14ClN3
tert-Butyl 7-(2-amino-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C15H21N3O3, CAS 2386704-68-1
tert-Butyl 7-(2-amino-2-oxoethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 2386704-68-1C15H21N3O3
tert-Butyl N-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)carbamate chemical structure, C14H21N3O2, CAS 2384639-76-1
tert-Butyl N-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)carbamate
CAS 2384639-76-1C14H21N3O2
Diethyl ((8-(diethoxyphosphoryl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl)phosphonate chemical structure, C17H30N2O6P2, CAS 2476495-41-5
Diethyl ((8-(diethoxyphosphoryl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methyl)phosphonate
CAS 2476495-41-5C17H30N2O6P2
7,7-Dimethyl-1,5,6,7-tetrahydro-1,8-naphthyridine chemical structure, C10H14N2, CAS 2632991-38-7
7,7-Dimethyl-1,5,6,7-tetrahydro-1,8-naphthyridine
CAS 2632991-38-7C10H14N2
5-Chloro-6-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C9H11ClN2, CAS 3017251-90-7
5-Chloro-6-methyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 3017251-90-7C9H11ClN2
tert-Butyl 7-((trimethylsilyl)ethynyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C18H26N2O2Si, CAS 3054531-34-6
tert-Butyl 7-((trimethylsilyl)ethynyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 3054531-34-6C18H26N2O2Si