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Murcko scaffold

1,2,3,4-Tetrahydro-1,8-naphthyridine scaffold

257 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
257
With full pages
38
Scaffold SMILES

c1cnc2c(c1)CCCN2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydro-1,8-naphthyridine page
Murcko scaffold c1cnc2c(c1)CCCN2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 145 to 192 of 257 chemicals

2-Methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-4-amine chemical structure, C9H13N3, CAS 1245210-75-6
2-Methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-4-amine
CAS 1245210-75-6C9H13N3
5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbonitrile chemical structure, C9H9N3, CAS 1260779-07-4
5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbonitrile
CAS 1260779-07-4C9H9N3
6-Methoxy-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C9H12N2O, CAS 1820735-64-5
6-Methoxy-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1820735-64-5C9H12N2O
5,6,7,8-Tetrahydro-1,8-naphthyridin-3-ol hydrochloride chemical structure, C8H11ClN2O, CAS 1820665-47-1
5,6,7,8-Tetrahydro-1,8-naphthyridin-3-ol hydrochloride
CAS 1820665-47-1C8H11ClN2O
tert-Butyl 6-iodo-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate chemical structure, C13H17IN2O2, CAS 2089320-06-7
tert-Butyl 6-iodo-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS 2089320-06-7C13H17IN2O2
Ethyl 5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylate chemical structure, C11H14N2O2, CAS 1417794-43-4
Ethyl 5,6,7,8-tetrahydro-1,8-naphthyridine-3-carboxylate
CAS 1417794-43-4C11H14N2O2
7-Amino-4-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-2-ol chemical structure, C9H13N3O, CAS 1279208-85-3
7-Amino-4-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-2-ol
CAS 1279208-85-3C9H13N3O
6-Bromo-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide chemical structure, C9H10BrN3O, CAS 1633012-49-3
6-Bromo-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
CAS 1633012-49-3C9H10BrN3O
6-Bromo-5-chloro-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C8H8BrClN2, CAS 1633014-63-7
6-Bromo-5-chloro-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1633014-63-7C8H8BrClN2
6-(8-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)hexanoic acid chemical structure, C19H28N2O4, CAS 1691255-79-4
6-(8-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)hexanoic acid
CAS 1691255-79-4C19H28N2O4
7-Ethenyl-1,2,3,4-tetrahydro-1,8-naphthyridinehydrochloride chemical structure, C10H12N2, CAS 872050-43-6
7-Ethenyl-1,2,3,4-tetrahydro-1,8-naphthyridinehydrochloride
CAS 872050-43-6C10H12N2
4-{8-[(tert-Butoxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}butanoic acid chemical structure, C17H24N2O4, CAS 1467822-57-6
4-{8-[(tert-Butoxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl}butanoic acid
CAS 1467822-57-6C17H24N2O4
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-methoxy-1,8-naphthyridine chemical structure, C12H18N2O3, CAS 1708976-89-9
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-methoxy-1,8-naphthyridine
CAS 1708976-89-9C12H18N2O3
6-Bromo-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C11H15BrN2O2, CAS 1708974-02-0
6-Bromo-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1708974-02-0C11H15BrN2O2
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbaldehyde chemical structure, C12H16N2O3, CAS 1708974-56-4
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbaldehyde
CAS 1708974-56-4C12H16N2O3
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-methanol chemical structure, C12H18N2O3, CAS 1708974-55-3
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-3-methanol
CAS 1708974-55-3C12H18N2O3
6-Bromo-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-2-methyl-1,8-naphthyridine chemical structure, C12H17BrN2O2, CAS 1708976-56-0
6-Bromo-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-2-methyl-1,8-naphthyridine
CAS 1708976-56-0C12H17BrN2O2
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-n-methyl-1,8-naphthyridine-3-methanamine chemical structure, C13H21N3O2, CAS 1708975-78-3
2-(Dimethoxymethyl)-5,6,7,8-tetrahydro-n-methyl-1,8-naphthyridine-3-methanamine
CAS 1708975-78-3C13H21N3O2
6-Chloro-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C11H15ClN2O2, CAS 1708973-99-2
6-Chloro-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1708973-99-2C11H15ClN2O2
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-iodo-1,8-naphthyridine chemical structure, C11H15IN2O2, CAS 1708974-83-7
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-iodo-1,8-naphthyridine
CAS 1708974-83-7C11H15IN2O2
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-2-methyl-1,8-naphthyridine chemical structure, C12H18N2O2, CAS 1708976-46-8
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-2-methyl-1,8-naphthyridine
CAS 1708976-46-8C12H18N2O2
6-(Difluoromethyl)-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine chemical structure, C12H16F2N2O2, CAS 1708975-59-0
6-(Difluoromethyl)-7-(dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS 1708975-59-0C12H16F2N2O2
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-1,8-naphthyridine chemical structure, C13H20N2O3, CAS 1708974-90-6
7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-6-(methoxymethyl)-1,8-naphthyridine
CAS 1708974-90-6C13H20N2O3
1-(2-Methyl-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)ethanone chemical structure, C11H14N2O, CAS 861046-50-6
1-(2-Methyl-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)ethanone
CAS 861046-50-6C11H14N2O