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Murcko scaffold

6-Phenyl-2-pyridone scaffold

360 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
360
With full pages
43
Scaffold SMILES

O=c1cccc(-c2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-Phenyl-2-pyridone page
Murcko scaffold O=c1cccc(-c2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 360 chemicals

6-Phenyl-2-pyridone chemical structure, C11H9NO, CAS 19006-82-7
6-Phenyl-2-pyridone
CAS 19006-82-7C11H9NO
2-Oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile chemical structure, C12H8N2O, CAS 43083-13-2
2-Oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile
CAS 43083-13-2C12H8N2O
Methyl 3-cyano-2-oxo-6-phenyl-1,2-dihydropyridine-4-carboxylate chemical structure, C14H10N2O3, CAS 502136-90-5
Methyl 3-cyano-2-oxo-6-phenyl-1,2-dihydropyridine-4-carboxylate
CAS 502136-90-5C14H10N2O3
Methyl 3-cyano-6-(4-fluorophenyl)-2-hydroxypyridine-4-carboxylate chemical structure, C14H9FN2O3, CAS 502136-91-6
Methyl 3-cyano-6-(4-fluorophenyl)-2-hydroxypyridine-4-carboxylate
CAS 502136-91-6C14H9FN2O3
6-(4-Chlorophenyl)-4-methylpyridin-2(1H)-one chemical structure, C12H10ClNO, CAS 242813-30-5
6-(4-Chlorophenyl)-4-methylpyridin-2(1H)-one
CAS 242813-30-5C12H10ClNO
6-(4-Methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C13H10N2O2, CAS 147269-06-5
6-(4-Methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 147269-06-5C13H10N2O2
1,2-Dihydro-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-3-pyridinecarbonitrile chemical structure, C14H9F3N2O2, CAS 147381-61-1
1,2-Dihydro-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-3-pyridinecarbonitrile
CAS 147381-61-1C14H9F3N2O2
Ethyl 5-cyano-6-oxo-2-phenyl-1,6-dihydro-3-pyridinecarboxylate chemical structure, C15H12N2O3, CAS 121017-78-5
Ethyl 5-cyano-6-oxo-2-phenyl-1,6-dihydro-3-pyridinecarboxylate
CAS 121017-78-5C15H12N2O3
4-(Methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H10N2OS, CAS 57663-06-6
4-(Methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 57663-06-6C13H10N2OS
6-(4-Fluorophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H6F4N2O, CAS 366022-33-5
6-(4-Fluorophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile
CAS 366022-33-5C13H6F4N2O
2-Hydroxy-6-(3-methoxyphenyl)-4-(trifluoromethyl)nicotinonitrile chemical structure, C14H9F3N2O2, CAS 439097-24-2
2-Hydroxy-6-(3-methoxyphenyl)-4-(trifluoromethyl)nicotinonitrile
CAS 439097-24-2C14H9F3N2O2
2-Hydroxy-6-(2-methoxyphenyl)-4-(trifluoromethyl)nicotinonitrile chemical structure, C14H9F3N2O2, CAS 439097-26-4
2-Hydroxy-6-(2-methoxyphenyl)-4-(trifluoromethyl)nicotinonitrile
CAS 439097-26-4C14H9F3N2O2
4-[Chloro(difluoro)methyl]-2-hydroxy-6-[4-(trifluoromethyl)phenyl]nicotinonitrile chemical structure, C14H6ClF5N2O, CAS 439097-28-6
4-[Chloro(difluoro)methyl]-2-hydroxy-6-[4-(trifluoromethyl)phenyl]nicotinonitrile
CAS 439097-28-6C14H6ClF5N2O
1-Methyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C14H12N2OS, CAS 67686-47-9
1-Methyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 67686-47-9C14H12N2OS
Ethyl 2-[3-cyano-4-(methylsulfanyl)-2-oxo-6-phenyl-1(2H)-pyridinyl]acetate chemical structure, C17H16N2O3S, CAS 478042-84-1
Ethyl 2-[3-cyano-4-(methylsulfanyl)-2-oxo-6-phenyl-1(2H)-pyridinyl]acetate
CAS 478042-84-1C17H16N2O3S
1-Allyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H14N2OS, CAS 478042-85-2
1-Allyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-85-2C16H14N2OS
4-(Methylsulfanyl)-2-oxo-6-phenyl-1-propyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H16N2OS, CAS 478042-86-3
4-(Methylsulfanyl)-2-oxo-6-phenyl-1-propyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-86-3C16H16N2OS
6-(4-Chlorophenyl)-1-ethyl-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H13ClN2OS, CAS 478042-94-3
6-(4-Chlorophenyl)-1-ethyl-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-94-3C15H13ClN2OS
6-(4-Chlorophenyl)-4-(methylsulfanyl)-2-oxo-1-propyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H15ClN2OS, CAS 478042-96-5
6-(4-Chlorophenyl)-4-(methylsulfanyl)-2-oxo-1-propyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-96-5C16H15ClN2OS
1-Allyl-6-(4-chlorophenyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C16H13ClN2OS, CAS 478042-97-6
1-Allyl-6-(4-chlorophenyl)-4-(methylsulfanyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 478042-97-6C16H13ClN2OS
Ethyl 2-[6-(4-chlorophenyl)-3-cyano-4-(methylsulfanyl)-2-oxo-1(2H)-pyridinyl]acetate chemical structure, C17H15ClN2O3S, CAS 478042-98-7
Ethyl 2-[6-(4-chlorophenyl)-3-cyano-4-(methylsulfanyl)-2-oxo-1(2H)-pyridinyl]acetate
CAS 478042-98-7C17H15ClN2O3S
6-(2-Chlorophenyl)-2-hydroxy-4-(trifluoromethyl)nicotinonitrile chemical structure, C13H6ClF3N2O, CAS 338749-70-5
6-(2-Chlorophenyl)-2-hydroxy-4-(trifluoromethyl)nicotinonitrile
CAS 338749-70-5C13H6ClF3N2O
6-(3-Chlorophenyl)-2-hydroxy-4-(trifluoromethyl)nicotinonitrile chemical structure, C13H6ClF3N2O, CAS 338749-71-6
6-(3-Chlorophenyl)-2-hydroxy-4-(trifluoromethyl)nicotinonitrile
CAS 338749-71-6C13H6ClF3N2O
6-(4-Chlorophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H6ClF3N2O, CAS 147381-62-2
6-(4-Chlorophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile
CAS 147381-62-2C13H6ClF3N2O