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Murcko scaffold

6-Phenyl-2-pyridone scaffold

360 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
360
With full pages
43
Scaffold SMILES

O=c1cccc(-c2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-Phenyl-2-pyridone page
Murcko scaffold O=c1cccc(-c2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 360 chemicals

4-(Trifluoromethyl)-1,2-dihydro-2-oxo-6-p-tolylpyridine-3-carbonitrile chemical structure, C14H9F3N2O, CAS 147381-60-0
4-(Trifluoromethyl)-1,2-dihydro-2-oxo-6-p-tolylpyridine-3-carbonitrile
CAS 147381-60-0C14H9F3N2O
1-Ethyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C15H14N2OS, CAS 478031-67-3
1-Ethyl-4-(methylsulfanyl)-2-oxo-6-phenyl-1,2-dihydro-3-pyridinecarbonitrile
CAS 478031-67-3C15H14N2OS
6-(4-Methylphenyl)pyridin-2(1H)-one chemical structure, C12H11NO, CAS 129720-57-6
6-(4-Methylphenyl)pyridin-2(1H)-one
CAS 129720-57-6C12H11NO
6-(O-Tolyl)pyridin-2-ol chemical structure, C12H11NO, CAS 300395-32-8
6-(O-Tolyl)pyridin-2-ol
CAS 300395-32-8C12H11NO
6-(4-Methoxyphenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C14H12N2O2, CAS 109273-57-6
6-(4-Methoxyphenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 109273-57-6C14H12N2O2
6-(4-Bromophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H6BrF3N2O, CAS 328012-22-2
6-(4-Bromophenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinecarbonitrile
CAS 328012-22-2C13H6BrF3N2O
6-(4-Isobutylphenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C17H18N2O, CAS 477320-32-4
6-(4-Isobutylphenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 477320-32-4C17H18N2O
4-Methyl-6-(4-methylphenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C14H12N2O, CAS 477320-28-8
4-Methyl-6-(4-methylphenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 477320-28-8C14H12N2O
2(1H)-Pyridinone, 4-(methylthio)-6-phenyl- chemical structure, C12H11NOS, CAS 114361-54-5
2(1H)-Pyridinone, 4-(methylthio)-6-phenyl-
CAS 114361-54-5C12H11NOS
6-(4-Bromophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H9BrN2O, CAS 109273-56-5
6-(4-Bromophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 109273-56-5C13H9BrN2O
6-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid chemical structure, C12H8ClNO3, CAS 147269-16-7
6-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
CAS 147269-16-7C12H8ClNO3
6-(4-Chlorophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H9ClN2O, CAS 134600-02-5
6-(4-Chlorophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 134600-02-5C13H9ClN2O
6-(4-Fluorophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile chemical structure, C13H9FN2O, CAS 477320-29-9
6-(4-Fluorophenyl)-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
CAS 477320-29-9C13H9FN2O
6-(2-Ethoxyphenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile chemical structure, C14H12N2O2, CAS 128173-61-5
6-(2-Ethoxyphenyl)-1,2-dihydro-2-oxo-3-pyridinecarbonitrile
CAS 128173-61-5C14H12N2O2
6-(4-Methylphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C13H10N2O, CAS 37670-85-2
6-(4-Methylphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 37670-85-2C13H10N2O
2-Hydroxy-6-(4-methylphenyl)pyridine-3-carboxylic acid chemical structure, C13H11NO3, CAS 147269-18-9
2-Hydroxy-6-(4-methylphenyl)pyridine-3-carboxylic acid
CAS 147269-18-9C13H11NO3
5-Cyano-6-oxo-2-phenyl-1,6-dihydropyridine-3-carboxylic acid chemical structure, C13H8N2O3, CAS 121017-84-3
5-Cyano-6-oxo-2-phenyl-1,6-dihydropyridine-3-carboxylic acid
CAS 121017-84-3C13H8N2O3
6-(3-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid chemical structure, C12H8ClNO3, CAS 147269-19-0
6-(3-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
CAS 147269-19-0C12H8ClNO3
6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C12H7ClN2O, CAS 147283-46-3
6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 147283-46-3C12H7ClN2O
6-[3-(1,1-Dimethylethoxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid chemical structure, C16H17NO4, CAS 147269-17-8
6-[3-(1,1-Dimethylethoxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
CAS 147269-17-8C16H17NO4
3-Nitro-6-phenylpyridin-2(1H)-one chemical structure, C11H8N2O3, CAS 39258-93-0
3-Nitro-6-phenylpyridin-2(1H)-one
CAS 39258-93-0C11H8N2O3
Ctk0I8776 chemical structure, C13H9F3N2O2, CAS 22122-95-8
Ctk0I8776
CAS 22122-95-8C13H9F3N2O2
6-(3-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile chemical structure, C12H7ClN2O, CAS 142499-65-8
6-(3-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
CAS 142499-65-8C12H7ClN2O
6-(2-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid chemical structure, C12H8ClNO3, CAS 147283-47-4
6-(2-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
CAS 147283-47-4C12H8ClNO3