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Murcko scaffold

Ring system with 3 rings and 15 atoms

56 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
56
With full pages
9
Scaffold SMILES

c1ccc(-c2n[nH]c3ncncc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2n[nH]c3ncncc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 56 chemicals

1-Ter-butyl-3-p-tolyl-1H-pyrazolo[3,4-D]pyrimidin-4-ylamine chemical structure, C16H19N5, CAS 172889-26-8
1-Ter-butyl-3-p-tolyl-1H-pyrazolo[3,4-D]pyrimidin-4-ylamine
CAS 172889-26-8C16H19N5
3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine chemical structure, C15H16ClN5, CAS 172889-27-9
3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine
CAS 172889-27-9C15H16ClN5
4,6-Diamino-1-methyl-3-phenyl pyrazolo[3,4-d]pyrimidine chemical structure, C12H12N6, CAS 58791-67-6
4,6-Diamino-1-methyl-3-phenyl pyrazolo[3,4-d]pyrimidine
CAS 58791-67-6C12H12N6
4,6-Diamino-1-methyl-3-[p-tolyl]pyrazolo[3,4-d]pyrimidine chemical structure, C13H14N6, CAS 58791-69-8
4,6-Diamino-1-methyl-3-[p-tolyl]pyrazolo[3,4-d]pyrimidine
CAS 58791-69-8C13H14N6
3-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl}phenol chemical structure, C15H17N5O, CAS 833481-60-0
3-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl}phenol
CAS 833481-60-0C15H17N5O
N-[1-tert-Butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]acetamide chemical structure, C17H18ClN5O, CAS 303984-55-6
N-[1-tert-Butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]acetamide
CAS 303984-55-6C17H18ClN5O
1-(tert-Butyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H16FN5, CAS 338391-69-8
1-(tert-Butyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 338391-69-8C15H16FN5
N-Acetyl-N-[1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide chemical structure, C19H20ClN5O2, CAS 338391-72-3
N-Acetyl-N-[1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide
CAS 338391-72-3C19H20ClN5O2
1-(tert-Butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H17N5, CAS 180903-16-6
1-(tert-Butyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 180903-16-6C15H17N5
3-(4-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H11N5O, CAS 80144-46-3
3-(4-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 80144-46-3C12H11N5O
3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C11H9N5, CAS 42754-69-8
3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 42754-69-8C11H9N5
3-(3,4-Dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C13H13N5O2, CAS 129852-39-7
3-(3,4-Dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 129852-39-7C13H13N5O2
3-(4-Chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C11H8ClN5, CAS 42754-70-1
3-(4-Chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 42754-70-1C11H8ClN5
Acji-99C chemical structure, C18H19N5O, CAS 1135195-64-0
Acji-99C
CAS 1135195-64-0C18H19N5O
3-(4-Azanyl-1-propan-2-YL-pyrazolo(3,4-D)pyrimidin-3-yl)phenol chemical structure, C14H15N5O, CAS 833481-69-9
3-(4-Azanyl-1-propan-2-YL-pyrazolo(3,4-D)pyrimidin-3-yl)phenol
CAS 833481-69-9C14H15N5O
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenol chemical structure, C14H14BrN5O, CAS 1092787-12-6
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-bromophenol
CAS 1092787-12-6C14H14BrN5O
3-(4-tert-Butylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H17N5, CAS 1092786-94-1
3-(4-tert-Butylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 1092786-94-1C15H17N5
3-(3-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C11H8N6O2, CAS 1092787-88-6
3-(3-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 1092787-88-6C11H8N6O2
3-p-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H11N5, CAS 186895-77-2
3-p-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 186895-77-2C12H11N5
2-Amino-5-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenol chemical structure, C14H16N6O, CAS 1092787-79-5
2-Amino-5-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenol
CAS 1092787-79-5C14H16N6O
3-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol chemical structure, C11H9N5O, CAS 1092786-96-3
3-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
CAS 1092786-96-3C11H9N5O
3-(3-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C11H10N6, CAS 1092787-86-4
3-(3-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 1092787-86-4C11H10N6
3-(p-Tolyl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C12H10N4, CAS 779325-81-4
3-(p-Tolyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS 779325-81-4C12H10N4
4-Chloro-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C11H7ClN4, CAS 164514-32-3
4-Chloro-3-phenyl-1H-pyrazolo[3,4-d]pyrimidine
CAS 164514-32-3C11H7ClN4