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Murcko scaffold

Ring system with 3 rings and 22 atoms

459 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 459
With full pages: 4

Scaffold SMILES

O=C1NC(=O)N(c2ccccc2)C(=O)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=O)N(c2ccccc2)C(=O)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 459 chemicals

(5Z)-5-[(4-Methylsulfanylphenyl)methylidene]-1-phenyl-1,3-diazinane-2,4,6-trione chemical structure, C18H14N2O3S, CAS 423736-03-2

(5Z)-5-[(4-Methylsulfanylphenyl)methylidene]-1-phenyl-1,3-diazinane-2,4,6-trione

CAS 423736-03-2C₁₈H₁₄N₂O₃S

(Z)-5-(4-(Dimethylamino)benzylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C19H17N3O3, CAS 5174-68-5

(Z)-5-(4-(Dimethylamino)benzylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

CAS 5174-68-5C₁₉H₁₇N₃O₃

5-[[4-(Dimethylamino)phenyl]methylene]-1-(2-methylphenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione chemical structure, C20H19N3O3, CAS 331739-55-0

5-[[4-(Dimethylamino)phenyl]methylene]-1-(2-methylphenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione

CAS 331739-55-0C₂₀H₁₉N₃O₃

(5Z)-5-(4-Ethylbenzylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C19H16N2O3, CAS 342014-40-8

(5Z)-5-(4-Ethylbenzylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione

CAS 342014-40-8C₁₉H₁₆N₂O₃

(5Z)-5-[(2,5-Dimethoxyphenyl)methylidene]-1-(2-methoxyphenyl)-1,3-diazinane-2,4,6-trione chemical structure, C20H18N2O6, CAS 352340-92-2

(5Z)-5-[(2,5-Dimethoxyphenyl)methylidene]-1-(2-methoxyphenyl)-1,3-diazinane-2,4,6-trione

CAS 352340-92-2C₂₀H₁₈N₂O₆

(5Z)-5-[4-(Dimethylamino)benzylidene]-6-hydroxy-3-(2-hydroxyphenyl)pyrimidine-2,4(3H,5H)-dione chemical structure, C19H17N3O4, CAS 300806-38-6

(5Z)-5-[4-(Dimethylamino)benzylidene]-6-hydroxy-3-(2-hydroxyphenyl)pyrimidine-2,4(3H,5H)-dione

CAS 300806-38-6C₁₉H₁₇N₃O₄

(5E)-1-(3-Bromophenyl)-5-[(3,4-dimethoxy-5-prop-2-enylphenyl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C22H19BrN2O5, CAS 425658-97-5

(5E)-1-(3-Bromophenyl)-5-[(3,4-dimethoxy-5-prop-2-enylphenyl)methylidene]-1,3-diazinane-2,4,6-trione

CAS 425658-97-5C₂₂H₁₉BrN₂O₅

Ethyl (2-chloro-4-{(E)-[1-(3,4-dimethylphenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}-6-methoxyphenoxy)acetate chemical structure, C24H23ClN2O7, CAS 425661-91-2

Ethyl (2-chloro-4-{(E)-[1-(3,4-dimethylphenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}-6-methoxyphenoxy)acetate

CAS 425661-91-2C₂₄H₂₃ClN₂O₇

5-[(2,4-Dimethoxyphenyl)methylidene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4,6-trione chemical structure, C20H18N2O6, CAS 346638-18-4

5-[(2,4-Dimethoxyphenyl)methylidene]-1-(3-methoxyphenyl)-1,3-diazinane-2,4,6-trione

CAS 346638-18-4C₂₀H₁₈N₂O₆

(5E)-1-(2,3-Dichlorophenyl)-5-(4-methoxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C18H12Cl2N2O4, CAS 593273-23-5

(5E)-1-(2,3-Dichlorophenyl)-5-(4-methoxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 593273-23-5C₁₈H₁₂Cl₂N₂O₄

(5Z)-1-(2,3-Dichlorophenyl)-5-[4-(dimethylamino)benzylidene]pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C19H15Cl2N3O3, CAS 593273-22-4

(5Z)-1-(2,3-Dichlorophenyl)-5-[4-(dimethylamino)benzylidene]pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 593273-22-4C₁₉H₁₅Cl₂N₃O₃

(5E)-5-(3-Chloro-4-ethoxy-5-methoxybenzylidene)-1-(2,3-dichlorophenyl)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C20H15Cl3N2O5, CAS 692268-50-1

(5E)-5-(3-Chloro-4-ethoxy-5-methoxybenzylidene)-1-(2,3-dichlorophenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 692268-50-1C₂₀H₁₅Cl₃N₂O₅

(5E)-1-(2,3-Dichlorophenyl)-5-[(2,3,4-trimethoxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C20H16Cl2N2O6, CAS 692274-80-9

(5E)-1-(2,3-Dichlorophenyl)-5-[(2,3,4-trimethoxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione

CAS 692274-80-9C₂₀H₁₆Cl₂N₂O₆

(5E)-1-(2,3-Dichlorophenyl)-5-(2,4-dimethoxy-3-methylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C20H16Cl2N2O5, CAS 692275-49-3

(5E)-1-(2,3-Dichlorophenyl)-5-(2,4-dimethoxy-3-methylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 692275-49-3C₂₀H₁₆Cl₂N₂O₅

2-(4-{(E)-[1-(2,4-Dichlorophenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}phenoxy)acetamide chemical structure, C19H13Cl2N3O5, CAS 432523-37-0

2-(4-{(E)-[1-(2,4-Dichlorophenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}phenoxy)acetamide

CAS 432523-37-0C₁₉H₁₃Cl₂N₃O₅

(5E)-5-[(4-Ethoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione chemical structure, C23H23FN2O4, CAS 432527-36-1

(5E)-5-[(4-Ethoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione

CAS 432527-36-1C₂₃H₂₃FN₂O₄

(5E)-1-(4-Chlorophenyl)-5-[(4-ethoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C23H23ClN2O4, CAS 432537-30-9

(5E)-1-(4-Chlorophenyl)-5-[(4-ethoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-1,3-diazinane-2,4,6-trione

CAS 432537-30-9C₂₃H₂₃ClN₂O₄

(5E)-5-[(3-Bromo-4-propan-2-yloxyphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione chemical structure, C20H16BrFN2O4, CAS 433308-57-7

(5E)-5-[(3-Bromo-4-propan-2-yloxyphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione

CAS 433308-57-7C₂₀H₁₆BrFN₂O₄

(5E)-1-(4-Bromophenyl)-5-(2,4,5-trimethoxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C20H17BrN2O6, CAS 433309-58-1

(5E)-1-(4-Bromophenyl)-5-(2,4,5-trimethoxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 433309-58-1C₂₀H₁₇BrN₂O₆

(5E)-1-(4-Bromophenyl)-5-(2-methoxy-5-nitrobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione chemical structure, C18H12BrN3O6, CAS 433311-01-4

(5E)-1-(4-Bromophenyl)-5-(2-methoxy-5-nitrobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

CAS 433311-01-4C₁₈H₁₂BrN₃O₆

(5E)-5-[(3-Chloro-4-propan-2-yloxyphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione chemical structure, C20H16ClFN2O4, CAS 433311-99-0

(5E)-5-[(3-Chloro-4-propan-2-yloxyphenyl)methylidene]-1-(4-fluorophenyl)-1,3-diazinane-2,4,6-trione

CAS 433311-99-0C₂₀H₁₆ClFN₂O₄

(5E)-1-(4-Chlorophenyl)-5-[(3-methoxy-2-propan-2-yloxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C21H19ClN2O5, CAS 433312-38-0

(5E)-1-(4-Chlorophenyl)-5-[(3-methoxy-2-propan-2-yloxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione

CAS 433312-38-0C₂₁H₁₉ClN₂O₅

(5E)-1-(4-Fluorophenyl)-5-[(3-methoxy-2-propan-2-yloxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione chemical structure, C21H19FN2O5, CAS 433318-66-2

(5E)-1-(4-Fluorophenyl)-5-[(3-methoxy-2-propan-2-yloxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione

CAS 433318-66-2C₂₁H₁₉FN₂O₅

(5Z)-5-[(3-Chloro-4-ethoxy-5-methoxyphenyl)methylidene]-1-(2-fluorophenyl)-1,3-diazinane-2,4,6-trione chemical structure, C20H16ClFN2O5, CAS 6437-07-6

(5Z)-5-[(3-Chloro-4-ethoxy-5-methoxyphenyl)methylidene]-1-(2-fluorophenyl)-1,3-diazinane-2,4,6-trione

CAS 6437-07-6C₂₀H₁₆ClFN₂O₅