Murcko scaffold
Ring system with 3 rings and 22 atoms
97 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 97
- With full pages
- 3
Scaffold SMILES
O=C(NC(=S)Nc1ccccc1)c1cccc2ccccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 97 chemicals
![N-[(4-Chlorophenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H13ClN2OS, CAS 163188-72-5](/s/ZGKFZHFFVYHYLH-UHFFFAOYSA-N.svg)
N-[(4-Chlorophenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 163188-72-5C18H13ClN2OS
![3-{[(1-Naphthoylamino)carbothioyl]amino}benzoic acid chemical structure, C19H14N2O3S, CAS 433952-85-3](/s/QANNZEMDLGIHOT-UHFFFAOYSA-N.svg)
3-{[(1-Naphthoylamino)carbothioyl]amino}benzoic acid
CAS 433952-85-3C19H14N2O3S
![2-{[(1-Naphthoylamino)carbonothioyl]amino}benzoic acid chemical structure, C19H14N2O3S, CAS 433972-06-6](/s/DWMQTUDIZCFHTQ-UHFFFAOYSA-N.svg)
2-{[(1-Naphthoylamino)carbonothioyl]amino}benzoic acid
CAS 433972-06-6C19H14N2O3S
![4-{[(Naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoic acid chemical structure, C19H14N2O3S, CAS 434311-92-9](/s/AXTSOKFHCKYXAB-UHFFFAOYSA-N.svg)
4-{[(Naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoic acid
CAS 434311-92-9C19H14N2O3S
![N-[(2-Hydroxyphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H14N2O2S, CAS 364749-28-0](/s/RDBAIRHXKQZHEA-UHFFFAOYSA-N.svg)
N-[(2-Hydroxyphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 364749-28-0C18H14N2O2S
![N-[(2-Hydroxy-4-methylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C19H16N2O2S, CAS 364610-47-9](/s/GCVSITQOKFAPNA-UHFFFAOYSA-N.svg)
N-[(2-Hydroxy-4-methylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 364610-47-9C19H16N2O2S
![N-[(4-Acetylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H16N2O2S, CAS 428504-59-0](/s/PJCBVNIFHVBZLA-UHFFFAOYSA-N.svg)
N-[(4-Acetylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 428504-59-0C20H16N2O2S
![N-[(2-Chlorophenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H13ClN2OS, CAS 163188-70-3](/s/QIXLSGUGJVVJSL-UHFFFAOYSA-N.svg)
N-[(2-Chlorophenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 163188-70-3C18H13ClN2OS
![N-[(2,6-Dimethylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H18N2OS, CAS 401612-51-9](/s/AMYQBAPHCDXMHU-UHFFFAOYSA-N.svg)
N-[(2,6-Dimethylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 401612-51-9C20H18N2OS
![N-[(2,5-Dimethylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H18N2OS, CAS 364625-77-4](/s/GSKNNWJDTSPSSZ-UHFFFAOYSA-N.svg)
N-[(2,5-Dimethylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 364625-77-4C20H18N2OS
![N-[(4-Fluorophenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H13FN2OS, CAS 401612-53-1](/s/FQQKVPPRBHWJDG-UHFFFAOYSA-N.svg)
N-[(4-Fluorophenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 401612-53-1C18H13FN2OS
![N-[(4-Ethylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H18N2OS, CAS 429622-24-2](/s/XZOFTWNPXZPKFQ-UHFFFAOYSA-N.svg)
N-[(4-Ethylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 429622-24-2C20H18N2OS
![N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C19H16N2O2S, CAS 429655-02-7](/s/OJLRJOVIQBYWGM-UHFFFAOYSA-N.svg)
N-[(2-Hydroxy-5-methylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 429655-02-7C19H16N2O2S
N-(5-Ethyl-2-hydroxyphenyl)-N'-(1-naphthoyl)thiourea
CAS 445412-59-9C20H18N2O2S
![Methyl 4-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoate chemical structure, C20H16N2O3S, CAS 356079-61-3](/s/AHEFJDLOKCDJHD-UHFFFAOYSA-N.svg)
Methyl 4-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoate
CAS 356079-61-3C20H16N2O3S
![N-[(2-Iodophenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H13IN2OS, CAS 445418-67-7](/s/VDFQBJWREBGSKX-UHFFFAOYSA-N.svg)
N-[(2-Iodophenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 445418-67-7C18H13IN2OS
![N-[(4-Acetamidophenyl)carbamothioyl]-5-bromonaphthalene-1-carboxamide chemical structure, C20H16BrN3O2S, CAS 429654-47-7](/s/NRHJFGKUFDJCRQ-UHFFFAOYSA-N.svg)
N-[(4-Acetamidophenyl)carbamothioyl]-5-bromonaphthalene-1-carboxamide
CAS 429654-47-7C20H16BrN3O2S
![5-Bromo-N-[(4-ethylphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H17BrN2OS, CAS 428860-71-3](/s/ABPGEUYOOROHDU-UHFFFAOYSA-N.svg)
5-Bromo-N-[(4-ethylphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 428860-71-3C20H17BrN2OS
![5-Bromo-N-[(2,4-dimethoxyphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C20H17BrN2O3S, CAS 429652-41-5](/s/VJTLAXWGXWQSJQ-UHFFFAOYSA-N.svg)
5-Bromo-N-[(2,4-dimethoxyphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 429652-41-5C20H17BrN2O3S
![5-Bromo-N-[(2,4-difluorophenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H11BrF2N2OS, CAS 838843-39-3](/s/RKXSVWFKSHXQNU-UHFFFAOYSA-N.svg)
5-Bromo-N-[(2,4-difluorophenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 838843-39-3C18H11BrF2N2OS
![N-[(5-Chloro-2-hydroxyphenyl)carbamothioyl]naphthalene-1-carboxamide chemical structure, C18H13ClN2O2S, CAS 445417-01-6](/s/XDOJZCXIVKNPHQ-UHFFFAOYSA-N.svg)
N-[(5-Chloro-2-hydroxyphenyl)carbamothioyl]naphthalene-1-carboxamide
CAS 445417-01-6C18H13ClN2O2S
![2-[(5-Bromonaphthalene-1-carbonyl)carbamothioylamino]benzoic acid chemical structure, C19H13BrN2O3S, CAS 531547-78-1](/s/DANCQTGKXCVGDT-UHFFFAOYSA-N.svg)
2-[(5-Bromonaphthalene-1-carbonyl)carbamothioylamino]benzoic acid
CAS 531547-78-1C19H13BrN2O3S
![5-({[(5-Bromonaphthalen-1-yl)carbonyl]carbamothioyl}amino)-2-chlorobenzoic acid chemical structure, C19H12BrClN2O3S, CAS 535945-34-7](/s/ANYYKQKQBSELPQ-UHFFFAOYSA-N.svg)
5-({[(5-Bromonaphthalen-1-yl)carbonyl]carbamothioyl}amino)-2-chlorobenzoic acid
CAS 535945-34-7C19H12BrClN2O3S
![3-({[(5-Bromonaphthalen-1-yl)carbonyl]carbamothioyl}amino)-2-methylbenzoic acid chemical structure, C20H15BrN2O3S, CAS 531515-21-6](/s/UMXMBXAANUPGNG-UHFFFAOYSA-N.svg)
3-({[(5-Bromonaphthalen-1-yl)carbonyl]carbamothioyl}amino)-2-methylbenzoic acid
CAS 531515-21-6C20H15BrN2O3S
- 4-Chloro-3-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoic acid531537-02-7C19H13ClN2O3S
- 5-Bromo-N-[[2-chloro-5-(propanoylamino)phenyl]carbamothioyl]naphthalene-1-carboxamide577985-63-8C21H17BrClN3O2S
- 4-Methyl-3-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoic acid433706-29-7C20H16N2O3S
- 2-Chloro-5-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoic acid434312-66-0C19H13ClN2O3S
- 5-Bromo-N-[[3-(2-methylpropanoylamino)phenyl]carbamothioyl]naphthalene-1-carboxamide462064-78-4C22H20BrN3O2S
- N-[[3-(2-Methylpropanoylamino)phenyl]carbamothioyl]naphthalene-1-carboxamide449774-22-5C22H21N3O2S
- Methyl 2-{[(1-naphthoylamino)carbonothioyl]amino}benzoate401619-95-2C20H16N2O3S
- N-[(3,4-Dichlorophenyl)carbamothioyl]naphthalene-1-carboxamide428504-44-3C18H12Cl2N2OS
- N-[[3-(Propanoylamino)phenyl]carbamothioyl]naphthalene-1-carboxamide356079-20-4C21H19N3O2S
- N-[[3-(Trifluoromethyl)phenyl]carbamothioyl]naphthalene-1-carboxamide356079-48-6C19H13F3N2OS
- N-[(2,5-Dichlorophenyl)carbamothioyl]naphthalene-1-carboxamide364625-16-1C18H12Cl2N2OS
- N-(2-Fluorophenyl)-N'-(1-naphthoyl)thiourea364746-57-6C18H13FN2OS
- N-[(4-Acetamidophenyl)carbamothioyl]naphthalene-1-carboxamide356079-28-2C20H17N3O2S
- N-[(4-Bromo-2,6-dimethylphenyl)carbamothioyl]naphthalene-1-carboxamide428834-62-2C20H17BrN2OS
- N-[(3-Chloro-2-methylphenyl)carbamothioyl]naphthalene-1-carboxamide428841-85-4C19H15ClN2OS
- N-[[4-(Diethylamino)phenyl]carbamothioyl]naphthalene-1-carboxamide356079-54-4C22H23N3OS
- N-[(2,4-Dimethoxyphenyl)carbamothioyl]naphthalene-1-carboxamide364623-63-2C20H18N2O3S
- N-[(3,5-Dichlorophenyl)carbamothioyl]naphthalene-1-carboxamide428841-74-1C18H12Cl2N2OS
- N-[(3-Nitrophenyl)carbamothioyl]naphthalene-1-carboxamide304677-55-2C18H13N3O3S
- N-[(4-Chloro-3-nitrophenyl)carbamothioyl]naphthalene-1-carboxamide428842-86-8C18H12ClN3O3S
- N-[[2-(Trifluoromethyl)phenyl]carbamothioyl]naphthalene-1-carboxamide356079-51-1C19H13F3N2OS
- N-[(2,4-Dichlorophenyl)carbamothioyl]naphthalene-1-carboxamide401612-52-0C18H12Cl2N2OS
- N-[(4-Bromophenyl)carbamothioyl]naphthalene-1-carboxamide163188-75-8C18H13BrN2OS
- Ethyl 4-{[(naphthalen-1-ylcarbonyl)carbamothioyl]amino}benzoate428852-97-5C21H18N2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1ccccc1](/scaffold/AJRIOXSLDWQDNT-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1ccccc117 chemicals
O=C(COc1cccc2c1CCNC2=O)Nc1ccccc111 chemicals![Scaffold O=C(CSc1ncnc2[nH]c(=O)[nH]c(=O)c12)Nc1ccccc1](/scaffold/NEPLTQYIBVZGDT-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncnc2[nH]c(=O)[nH]c(=O)c12)Nc1ccccc110 chemicals![Scaffold O=C(COc1cccc2c(=O)[nH]ccc12)Nc1ccccc1](/scaffold/KUKRKXYIWBTJFC-UHFFFAOYSA-N/structure.svg)
O=C(COc1cccc2c(=O)[nH]ccc12)Nc1ccccc19 chemicals
O=C(NNC(=O)c1cccc2ccccc12)c1ccccc19 chemicals
O=C(CSc1nncc2ccccc12)Nc1ccccc19 chemicals
O=C(NN=Cc1cccc2ccccc12)c1ccccc18 chemicals
O=C(COc1cccc2ccccc12)Nc1ccccc17 chemicals
O=C(COc1ccccc1)Nc1cccc2ccccc127 chemicals![Scaffold O=C(NNC(=O)c1n[nH]c(=O)c2ccccc12)c1ccccc1](/scaffold/IDQDJYQKVHYGRV-UHFFFAOYSA-N/structure.svg)
O=C(NNC(=O)c1n[nH]c(=O)c2ccccc12)c1ccccc17 chemicals
O=C1CN(C(=O)COC(=O)c2ccccc2)c2ccccc2N17 chemicals
O=C(COC(=O)c1ccnc2ccccc12)c1ccccc17 chemicals