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Murcko scaffold

2H-1,4-Benzoxazin-3(4H)-one, 6-(2-phenyl-4-thiazolyl)- scaffold

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
9
With full pages
1
Scaffold SMILES

O=C1COc2ccc(-c3csc(-c4ccccc4)n3)cc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2H-1,4-Benzoxazin-3(4H)-one, 6-(2-phenyl-4-thiazolyl)- page
Murcko scaffold O=C1COc2ccc(-c3csc(-c4ccccc4)n3)cc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)- chemical structure, C17H11ClN2O2S, CAS 114566-47-1
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)-
CAS 114566-47-1C17H11ClN2O2S
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)-4-methyl- chemical structure, C18H13ClN2O2S, CAS 114566-50-6
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)-4-methyl-
CAS 114566-50-6C18H13ClN2O2S
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-methoxyphenyl)-4-thiazolyl)- chemical structure, C18H14N2O3S, CAS 114566-48-2
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-methoxyphenyl)-4-thiazolyl)-
CAS 114566-48-2C18H14N2O3S
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-phenyl-4-thiazolyl)- chemical structure, C17H12N2O2S, CAS 114566-45-9
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-phenyl-4-thiazolyl)-
CAS 114566-45-9C17H12N2O2S
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-methoxyphenyl)-4-thiazolyl)-4-methyl- chemical structure, C19H16N2O3S, CAS 114566-51-7
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-methoxyphenyl)-4-thiazolyl)-4-methyl-
CAS 114566-51-7C19H16N2O3S
2H-1,4-Benzoxazin-3(4H)-one, 4-ethyl-6-(2-phenyl-4-thiazolyl)- chemical structure, C19H16N2O2S, CAS 114566-52-8
2H-1,4-Benzoxazin-3(4H)-one, 4-ethyl-6-(2-phenyl-4-thiazolyl)-
CAS 114566-52-8C19H16N2O2S
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)-4-ethyl- chemical structure, C19H15ClN2O2S, CAS 114566-54-0
2H-1,4-Benzoxazin-3(4H)-one, 6-(2-(4-chlorophenyl)-4-thiazolyl)-4-ethyl-
CAS 114566-54-0C19H15ClN2O2S
2H-1,4-Benzoxazin-3(4H)-one, 4-ethyl-6-(2-(4-methoxyphenyl)-4-thiazolyl)- chemical structure, C20H18N2O3S, CAS 114566-55-1
2H-1,4-Benzoxazin-3(4H)-one, 4-ethyl-6-(2-(4-methoxyphenyl)-4-thiazolyl)-
CAS 114566-55-1C20H18N2O3S
6-[2-(3-Methylphenyl)-1,3-thiazol-4-yl]-3,4-dihydro-2H-1,4-benzoxazin-3-one chemical structure, C18H14N2O2S, CAS 875437-65-3
6-[2-(3-Methylphenyl)-1,3-thiazol-4-yl]-3,4-dihydro-2H-1,4-benzoxazin-3-one
CAS 875437-65-3C18H14N2O2S