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Murcko scaffold

Ring system with 4 rings and 21 atoms

65 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
65
With full pages
8
Scaffold SMILES

c1ccc(C2=NNC(c3ccc4nccnc4c3)C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=NNC(c3ccc4nccnc4c3)C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

4-Oxo-4-(5-phenyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-2-yl)butanoic acid chemical structure, C21H18N4O3, CAS 442649-90-3
4-Oxo-4-(5-phenyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-2-yl)butanoic acid
CAS 442649-90-3C21H18N4O3
6-(1-(Methylsulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C18H16N4O2S, CAS 442649-92-5
6-(1-(Methylsulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 442649-92-5C18H16N4O2S
N-[4-(2-Acetyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide chemical structure, C20H19N5O3S, CAS 710987-39-6
N-[4-(2-Acetyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide
CAS 710987-39-6C20H19N5O3S
N-[4-(2-Methylsulfonyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide chemical structure, C19H19N5O4S2, CAS 710987-42-1
N-[4-(2-Methylsulfonyl-3-quinoxalin-6-yl-3,4-dihydropyrazol-5-yl)phenyl]methanesulfonamide
CAS 710987-42-1C19H19N5O4S2
6-(3-(4-Methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C19H18N4O3S, CAS 797775-36-1
6-(3-(4-Methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 797775-36-1C19H18N4O3S
N-{4-[1-Propanoyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H21N5O3S, CAS 797780-87-1
N-{4-[1-Propanoyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 797780-87-1C21H21N5O3S
1-(3-Phenyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C19H16N4O, CAS 442649-89-0
1-(3-Phenyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 442649-89-0C19H16N4O
6-(1-(Methylsulfonyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C19H18N4O2S, CAS 712308-47-9
6-(1-(Methylsulfonyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 712308-47-9C19H18N4O2S
6-(1-(Ethylsulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C19H18N4O2S, CAS 864925-22-4
6-(1-(Ethylsulfonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 864925-22-4C19H18N4O2S
N-(4-(1-Acetyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)acetamide chemical structure, C21H19N5O2, CAS 927065-86-9
N-(4-(1-Acetyl-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)acetamide
CAS 927065-86-9C21H19N5O2
N-(2-(1-(Methylsulfonyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C19H19N5O4S2, CAS 941948-31-8
N-(2-(1-(Methylsulfonyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 941948-31-8C19H19N5O4S2
6-(3-(3-Methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C19H18N4O3S, CAS 941913-18-4
6-(3-(3-Methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 941913-18-4C19H18N4O3S
6-(3-(3,4-Dimethoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline chemical structure, C20H20N4O4S, CAS 941913-20-8
6-(3-(3,4-Dimethoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoxaline
CAS 941913-20-8C20H20N4O4S
1-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one chemical structure, C22H22N4O2, CAS 941913-16-2
1-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one
CAS 941913-16-2C22H22N4O2
1-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one chemical structure, C22H22N4O2, CAS 942034-23-3
1-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one
CAS 942034-23-3C22H22N4O2
4-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C22H20N4O4, CAS 941905-40-4
4-(3-(3-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 941905-40-4C22H20N4O4
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C21H20N4O3, CAS 942034-25-5
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 942034-25-5C21H20N4O3
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one chemical structure, C23H24N4O3, CAS 941905-43-7
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one
CAS 941905-43-7C23H24N4O3
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one chemical structure, C22H22N4O3, CAS 942034-27-7
1-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS 942034-27-7C22H22N4O3
4-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C23H22N4O5, CAS 941905-46-0
4-(3-(3,4-Dimethoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 941905-46-0C23H22N4O5
2-Methyl-1-(5-(quinoxalin-6-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one chemical structure, C22H22N4O, CAS 941913-22-0
2-Methyl-1-(5-(quinoxalin-6-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS 941913-22-0C22H22N4O
1-(5-(Quinoxalin-6-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one chemical structure, C22H22N4O, CAS 942034-29-9
1-(5-(Quinoxalin-6-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one
CAS 942034-29-9C22H22N4O
1-[3-(4-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one chemical structure, C22H22N4O2, CAS 941905-49-3
1-[3-(4-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one
CAS 941905-49-3C22H22N4O2
1-(3-(4-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one chemical structure, C22H22N4O2, CAS 941913-24-2
1-(3-(4-Methoxyphenyl)-5-(quinoxalin-6-yl)-4,5-dihydro-1H-pyrazol-1-yl)butan-1-one
CAS 941913-24-2C22H22N4O2