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Murcko scaffold

3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-phenylpyrrolidine-2,5-dione scaffold

28 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
28
With full pages
4
Scaffold SMILES

O=C1CC(N2CCc3ccccc3C2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-phenylpyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(N2CCc3ccccc3C2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C20H20N2O2, CAS 317324-77-9
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-methylphenyl)pyrrolidine-2,5-dione
CAS 317324-77-9C20H20N2O2
3-(3,4-Dihydro-2(1H)-isoquinolinyl)-1-(4-ethoxyphenyl)-2,5-pyrrolidinedione chemical structure, C21H22N2O3, CAS 354789-28-9
3-(3,4-Dihydro-2(1H)-isoquinolinyl)-1-(4-ethoxyphenyl)-2,5-pyrrolidinedione
CAS 354789-28-9C21H22N2O3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C20H20N2O3, CAS 371143-96-3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxyphenyl)pyrrolidine-2,5-dione
CAS 371143-96-3C20H20N2O3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxy-4-nitrophenyl)pyrrolidine-2,5-dione chemical structure, C20H19N3O5, CAS 433941-85-6
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxy-4-nitrophenyl)pyrrolidine-2,5-dione
CAS 433941-85-6C20H19N3O5
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C20H20N2O3, CAS 354793-14-9
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 354793-14-9C20H20N2O3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(3,4-dimethylphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O2, CAS 488724-25-0
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(3,4-dimethylphenyl)pyrrolidine-2,5-dione
CAS 488724-25-0C21H22N2O2
Ethyl 4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C22H22N2O4, CAS 500270-70-2
Ethyl 4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 500270-70-2C22H22N2O4
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methylphenyl)pyrrolidine-2,5-dione chemical structure, C20H20N2O2, CAS 497867-98-8
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methylphenyl)pyrrolidine-2,5-dione
CAS 497867-98-8C20H20N2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-nitrophenyl)pyrrolidine-2,5-dione chemical structure, C19H17N3O4, CAS 488861-74-1
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-nitrophenyl)pyrrolidine-2,5-dione
CAS 488861-74-1C19H17N3O4
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O4, CAS 488100-32-9
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione
CAS 488100-32-9C21H22N2O4
1-(2,3-Dichlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione chemical structure, C19H16Cl2N2O2, CAS 488841-90-3
1-(2,3-Dichlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione
CAS 488841-90-3C19H16Cl2N2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione chemical structure, C20H17F3N2O2, CAS 511515-45-0
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-[3-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione
CAS 511515-45-0C20H17F3N2O2
1-(4-Chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione chemical structure, C19H17ClN2O2, CAS 443328-30-1
1-(4-Chlorophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione
CAS 443328-30-1C19H17ClN2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2,5-dimethylphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O2, CAS 511515-43-8
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2,5-dimethylphenyl)pyrrolidine-2,5-dione
CAS 511515-43-8C21H22N2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C19H17FN2O2, CAS 443328-67-4
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 443328-67-4C19H17FN2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxy-5-methylphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O3, CAS 700850-46-0
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(2-methoxy-5-methylphenyl)pyrrolidine-2,5-dione
CAS 700850-46-0C21H22N2O3
1-(4-Bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione chemical structure, C19H17BrN2O2, CAS 499987-43-8
1-(4-Bromophenyl)-3-(3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione
CAS 499987-43-8C19H17BrN2O2
N-{4-[3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2,5-dioxopyrrolidin-1-yl]phenyl}acetamide chemical structure, C21H21N3O3, CAS 406179-34-8
N-{4-[3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2,5-dioxopyrrolidin-1-yl]phenyl}acetamide
CAS 406179-34-8C21H21N3O3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-isopropylphenyl)pyrrolidine-2,5-dione chemical structure, C22H24N2O2, CAS 487022-66-2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-isopropylphenyl)pyrrolidine-2,5-dione
CAS 487022-66-2C22H24N2O2
1-(2-Chlorophenyl)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2,5-pyrrolidinedione chemical structure, C19H17ClN2O2, CAS 496774-15-3
1-(2-Chlorophenyl)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2,5-pyrrolidinedione
CAS 496774-15-3C19H17ClN2O2
3-(3,4-Dihydro-2(1H)-isoquinolinyl)-1-(3-methoxyphenyl)-2,5-pyrrolidinedione chemical structure, C20H20N2O3, CAS 511515-44-9
3-(3,4-Dihydro-2(1H)-isoquinolinyl)-1-(3-methoxyphenyl)-2,5-pyrrolidinedione
CAS 511515-44-9C20H20N2O3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-phenylpyrrolidine-2,5-dione chemical structure, C19H18N2O2, CAS 312937-94-3
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-phenylpyrrolidine-2,5-dione
CAS 312937-94-3C19H18N2O2
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-ethylphenyl)pyrrolidine-2,5-dione chemical structure, C21H22N2O2, CAS 524057-97-4
3-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-(4-ethylphenyl)pyrrolidine-2,5-dione
CAS 524057-97-4C21H22N2O2
1-(5-Chloro-2-methoxyphenyl)-3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione chemical structure, C22H23ClN2O5, CAS 1087660-13-6
1-(5-Chloro-2-methoxyphenyl)-3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)pyrrolidine-2,5-dione
CAS 1087660-13-6C22H23ClN2O5