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Murcko scaffold

Ring system with 4 rings and 21 atoms

29 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
29
With full pages
14
Scaffold SMILES

c1ccc(-n2ccc(-c3ccc4c(c3)OCCO4)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-n2ccc(-c3ccc4c(c3)OCCO4)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde chemical structure, C18H14N2O3, CAS 213748-09-5
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde
CAS 213748-09-5C18H14N2O3
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl)methanol chemical structure, C18H16N2O3, CAS 618383-31-6
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl)methanol
CAS 618383-31-6C18H16N2O3
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]-N-(prop-2-en-1-yl)prop-2-enamide chemical structure, C24H20N4O3, CAS 882151-39-5
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]-N-(prop-2-en-1-yl)prop-2-enamide
CAS 882151-39-5C24H20N4O3
(E)-2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenylpyrazol-4-yl]-N-(2-methoxyethyl)prop-2-enamide chemical structure, C24H22N4O4, CAS 477524-66-6
(E)-2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenylpyrazol-4-yl]-N-(2-methoxyethyl)prop-2-enamide
CAS 477524-66-6C24H22N4O4
(E)-2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenylpyrazol-4-yl]-N-octylprop-2-enamide chemical structure, C29H32N4O3, CAS 477524-31-5
(E)-2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenylpyrazol-4-yl]-N-octylprop-2-enamide
CAS 477524-31-5C29H32N4O3
3-[3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoic acid chemical structure, C20H16N2O4, CAS 379726-46-2
3-[3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enoic acid
CAS 379726-46-2C20H16N2O4
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enamide chemical structure, C21H16N4O3, CAS 387846-15-3
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enamide
CAS 387846-15-3C21H16N4O3
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]-N-(3-methoxypropyl)prop-2-enamide chemical structure, C25H24N4O4, CAS 956198-20-2
2-Cyano-3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazol-4-yl]-N-(3-methoxypropyl)prop-2-enamide
CAS 956198-20-2C25H24N4O4
5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-phenylpyrazole-3-carboxylic acid chemical structure, C18H14N2O4, CAS 618383-01-0
5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-phenylpyrazole-3-carboxylic acid
CAS 618383-01-0C18H14N2O4
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde chemical structure, C19H16N2O3, CAS 618098-94-5
3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde
CAS 618098-94-5C19H16N2O3
(1-(3-CL-4-F-PH)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-4-yl)methanol chemical structure, C18H14ClFN2O3, CAS 618444-59-0
(1-(3-CL-4-F-PH)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-4-yl)methanol
CAS 618444-59-0C18H14ClFN2O3
(1-(4-CL-PH)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-4-yl)methanol chemical structure, C18H15ClN2O3, CAS 618383-37-2
(1-(4-CL-PH)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1H-pyrazol-4-yl)methanol
CAS 618383-37-2C18H15ClN2O3
1-(3-Chloro-4-fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-5-carboxylic acid chemical structure, C18H12ClFN2O4, CAS 618383-07-6
1-(3-Chloro-4-fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-5-carboxylic acid
CAS 618383-07-6C18H12ClFN2O4
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(m-tolyl)-1H-pyrazole-5-carboxylic acid chemical structure, C19H16N2O4, CAS 618383-05-4
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(m-tolyl)-1H-pyrazole-5-carboxylic acid
CAS 618383-05-4C19H16N2O4
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(2-F-PH)-1H-pyrazol-4-yl)methanol chemical structure, C18H15FN2O3, CAS 618383-43-0
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(2-F-PH)-1H-pyrazol-4-yl)methanol
CAS 618383-43-0C18H15FN2O3
1-(2-Fluorophenyl)-3-(2,3-dihydrobenzo[B][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde chemical structure, C18H13FN2O3, CAS 618101-80-7
1-(2-Fluorophenyl)-3-(2,3-dihydrobenzo[B][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde
CAS 618101-80-7C18H13FN2O3
1-(4-Fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde chemical structure, C18H13FN2O3, CAS 618101-64-7
1-(4-Fluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde
CAS 618101-64-7C18H13FN2O3
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C19H16N2O5, CAS 618383-04-3
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic acid
CAS 618383-04-3C19H16N2O5
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(2-methoxyphenyl)-1H-pyrazole-5-carboxylic acid chemical structure, C19H16N2O5, CAS 618383-08-7
3-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-(2-methoxyphenyl)-1H-pyrazole-5-carboxylic acid
CAS 618383-08-7C19H16N2O5
1-(4-Bromophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylic acid chemical structure, C18H13BrN2O4, CAS 618383-03-2
1-(4-Bromophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylic acid
CAS 618383-03-2C18H13BrN2O4
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-F-PH)-1H-pyrazol-4-yl)methanol chemical structure, C18H15FN2O3, CAS 618444-48-7
(3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-(4-F-PH)-1H-pyrazol-4-yl)methanol
CAS 618444-48-7C18H15FN2O3
1-(4-Chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-4-carboxaldehyde chemical structure, C18H13ClN2O3, CAS 618099-01-7
1-(4-Chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-4-carboxaldehyde
CAS 618099-01-7C18H13ClN2O3
1-(4-Chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylic acid chemical structure, C18H13ClN2O4, CAS 618383-02-1
1-(4-Chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-5-carboxylic acid
CAS 618383-02-1C18H13ClN2O4
3-(2,3-Dihydrobenzo[B][1,4]dioxin-7-yl)-1-P-tolyl-1H-pyrazole-5-carboxylic acid chemical structure, C19H16N2O4, CAS 618383-18-9
3-(2,3-Dihydrobenzo[B][1,4]dioxin-7-yl)-1-P-tolyl-1H-pyrazole-5-carboxylic acid
CAS 618383-18-9C19H16N2O4