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Murcko scaffold

Ring system with 4 rings and 21 atoms

67 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
67
With full pages
8
Scaffold SMILES

c1ccc(C2=NNC(c3cnc4ccccc4c3)C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=NNC(c3cnc4ccccc4c3)C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 67 chemicals

4-[3-(2-Chloro-8-methylquinolin-3-yl)-5-(3,4-dimethoxyphenyl)-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid chemical structure, C25H24ClN3O5, CAS 402951-00-2
4-[3-(2-Chloro-8-methylquinolin-3-yl)-5-(3,4-dimethoxyphenyl)-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid
CAS 402951-00-2C25H24ClN3O5
4-[5-(2-Chloroquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid chemical structure, C24H22ClN3O5, CAS 333750-07-5
4-[5-(2-Chloroquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid
CAS 333750-07-5C24H22ClN3O5
4-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C23H19Cl2N3O4, CAS 442649-45-8
4-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 442649-45-8C23H19Cl2N3O4
2-Chloro-7-methoxy-3-(1-(methylsulfonyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline chemical structure, C21H20ClN3O3S, CAS 442650-11-5
2-Chloro-7-methoxy-3-(1-(methylsulfonyl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline
CAS 442650-11-5C21H20ClN3O3S
1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one chemical structure, C22H20ClN3O, CAS 710284-70-1
1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one
CAS 710284-70-1C22H20ClN3O
4-(5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C23H19Cl2N3O4, CAS 442649-84-5
4-(5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 442649-84-5C23H19Cl2N3O4
4-(5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C24H22ClN3O4, CAS 685135-48-2
4-(5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 685135-48-2C24H22ClN3O4
1-[3-(2-Chloro-7-methoxyquinolin-3-yl)-5-(3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C22H20ClN3O3, CAS 865615-73-2
1-[3-(2-Chloro-7-methoxyquinolin-3-yl)-5-(3-methoxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone
CAS 865615-73-2C22H20ClN3O3
5-(3-(4-Bromophenyl)-5-(2-chloro-7-methylquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid chemical structure, C24H21BrClN3O3, CAS 394239-66-8
5-(3-(4-Bromophenyl)-5-(2-chloro-7-methylquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid
CAS 394239-66-8C24H21BrClN3O3
5-[3-(4-Bromophenyl)-5-(2-chloro-7-ethoxyquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid chemical structure, C25H23BrClN3O4, CAS 394239-71-5
5-[3-(4-Bromophenyl)-5-(2-chloro-7-ethoxyquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid
CAS 394239-71-5C25H23BrClN3O4
2-Chloro-6-ethoxy-3-[5-(4-methoxyphenyl)-2-methylsulfonyl-3,4-dihydropyrazol-3-yl]quinoline chemical structure, C22H22ClN3O4S, CAS 685135-40-4
2-Chloro-6-ethoxy-3-[5-(4-methoxyphenyl)-2-methylsulfonyl-3,4-dihydropyrazol-3-yl]quinoline
CAS 685135-40-4C22H22ClN3O4S
4-[5-(2-Chloro-8-methylquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid chemical structure, C23H20ClN3O3, CAS 362491-10-9
4-[5-(2-Chloro-8-methylquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid
CAS 362491-10-9C23H20ClN3O3
1-[5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one chemical structure, C24H24ClN3O4, CAS 442649-79-8
1-[5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one
CAS 442649-79-8C24H24ClN3O4
4-(5-(2-Chloro-6-methylquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C25H24ClN3O5, CAS 384356-77-8
4-(5-(2-Chloro-6-methylquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 384356-77-8C25H24ClN3O5
1-[5-(2-Chloro-6-methoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one chemical structure, C22H20ClN3O2, CAS 442649-75-4
1-[5-(2-Chloro-6-methoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]propan-1-one
CAS 442649-75-4C22H20ClN3O2
1-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one chemical structure, C23H22ClN3O2, CAS 442649-41-4
1-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS 442649-41-4C23H22ClN3O2
5-[5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid chemical structure, C25H24ClN3O4, CAS 685135-45-9
5-[5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid
CAS 685135-45-9C25H24ClN3O4
4-(5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C25H24ClN3O4, CAS 685135-43-7
4-(5-(2-Chloro-6-ethoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid
CAS 685135-43-7C25H24ClN3O4
2-Chloro-7-ethoxy-3-(3-(4-methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline chemical structure, C22H22ClN3O4S, CAS 499208-84-3
2-Chloro-7-ethoxy-3-(3-(4-methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline
CAS 499208-84-3C22H22ClN3O4S
2-Chloro-3-(3-(4-methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-8-methylquinoline chemical structure, C21H20ClN3O3S, CAS 442650-01-3
2-Chloro-3-(3-(4-methoxyphenyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-8-methylquinoline
CAS 442650-01-3C21H20ClN3O3S
5-[5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid chemical structure, C26H26ClN3O6, CAS 442649-51-6
5-[5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-oxopentanoic acid
CAS 442649-51-6C26H26ClN3O6
1-[3-(2-Chloro-7-methoxyquinolin-3-yl)-5-(4-chlorophenyl)-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C21H17Cl2N3O2, CAS 488802-39-7
1-[3-(2-Chloro-7-methoxyquinolin-3-yl)-5-(4-chlorophenyl)-3,4-dihydropyrazol-2-yl]ethanone
CAS 488802-39-7C21H17Cl2N3O2
1-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C22H20ClN3O2, CAS 370847-75-9
1-(5-(2-Chloro-7-methoxyquinolin-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS 370847-75-9C22H20ClN3O2
5-(5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid chemical structure, C25H24ClN3O5, CAS 442649-83-4
5-(5-(2-Chloro-6-methoxyquinolin-3-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid
CAS 442649-83-4C25H24ClN3O5