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Murcko scaffold

Ring system with 3 rings and 21 atoms

17 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
17
With full pages
3
Scaffold SMILES

O=C(CN1CCN(c2ccccc2)CC1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCN(c2ccccc2)CC1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-[4-(4-Fluorophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone chemical structure, C16H22FN3O2, CAS 486457-15-2
2-[4-(4-Fluorophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone
CAS 486457-15-2C16H22FN3O2
1-Morpholin-4-yl-2-[4-(4-nitrophenyl)piperazin-1-yl]ethanone chemical structure, C16H22N4O4, CAS 330633-98-2
1-Morpholin-4-yl-2-[4-(4-nitrophenyl)piperazin-1-yl]ethanone
CAS 330633-98-2C16H22N4O4
2-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone chemical structure, C16H21ClN4O4, CAS 330634-02-1
2-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone
CAS 330634-02-1C16H21ClN4O4
2-[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone chemical structure, C16H21ClN4O4, CAS 309743-23-5
2-[4-(4-Chloro-2-nitrophenyl)piperazin-1-yl]-1-morpholin-4-ylethanone
CAS 309743-23-5C16H21ClN4O4
2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-1-morpholin-4-yl-ethanone chemical structure, C16H22ClN3O2, CAS 1170561-10-0
2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-1-morpholin-4-yl-ethanone
CAS 1170561-10-0C16H22ClN3O2
2-[4-(2-Methylphenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one chemical structure, C17H25N3O2, CAS 1047250-46-3
2-[4-(2-Methylphenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one
CAS 1047250-46-3C17H25N3O2
2-[4-(4-Amino-3-methoxyphenyl)piperazin-1-yl]-1-morpholin-4-ylethanone chemical structure, C17H26N4O3, CAS 877676-32-9
2-[4-(4-Amino-3-methoxyphenyl)piperazin-1-yl]-1-morpholin-4-ylethanone
CAS 877676-32-9C17H26N4O3
1-(2,6-Dimethylmorpholin-4-yl)-2-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one chemical structure, C20H31N3O2, CAS 2180500-29-0
1-(2,6-Dimethylmorpholin-4-yl)-2-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one
CAS 2180500-29-0C20H31N3O2
2-[4-(2,4-Difluorophenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one chemical structure, C16H21F2N3O2, CAS 2877650-23-0
2-[4-(2,4-Difluorophenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one
CAS 2877650-23-0C16H21F2N3O2
1-(Morpholin-4-yl)-2-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}ethan-1-one chemical structure, C17H22F3N3O2, CAS 2877657-92-4
1-(Morpholin-4-yl)-2-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}ethan-1-one
CAS 2877657-92-4C17H22F3N3O2
1-(2,6-Dimethylmorpholin-4-yl)-2-[4-(2-methylphenyl)piperazin-1-yl]ethan-1-one chemical structure, C19H29N3O2, CAS 2877685-65-7
1-(2,6-Dimethylmorpholin-4-yl)-2-[4-(2-methylphenyl)piperazin-1-yl]ethan-1-one
CAS 2877685-65-7C19H29N3O2
2-[4-(2,4-Difluorophenyl)piperazin-1-yl]-1-(2,6-dimethylmorpholin-4-yl)ethan-1-one chemical structure, C18H25F2N3O2, CAS 2877672-59-6
2-[4-(2,4-Difluorophenyl)piperazin-1-yl]-1-(2,6-dimethylmorpholin-4-yl)ethan-1-one
CAS 2877672-59-6C18H25F2N3O2
2-[4-(4-Chlorophenyl)piperazin-1-yl]-1-(2,6-dimethylmorpholin-4-yl)ethan-1-one chemical structure, C18H26ClN3O2, CAS 2877650-02-5
2-[4-(4-Chlorophenyl)piperazin-1-yl]-1-(2,6-dimethylmorpholin-4-yl)ethan-1-one
CAS 2877650-02-5C18H26ClN3O2
2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one chemical structure, C17H24ClN3O2, CAS 2770620-57-8
2-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one
CAS 2770620-57-8C17H24ClN3O2
2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one chemical structure, C16H21Cl2N3O2, CAS 2770643-85-9
2-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-1-(morpholin-4-yl)ethan-1-one
CAS 2770643-85-9C16H21Cl2N3O2
4-{4-[2-(Morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}benzene-1-sulfonamide chemical structure, C16H24N4O4S, CAS 2196605-62-4
4-{4-[2-(Morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}benzene-1-sulfonamide
CAS 2196605-62-4C16H24N4O4S
4-{4-[2-(2,6-Dimethylmorpholin-4-yl)-2-oxoethyl]piperazin-1-yl}benzene-1-sulfonamide chemical structure, C18H28N4O4S, CAS 2188910-51-0
4-{4-[2-(2,6-Dimethylmorpholin-4-yl)-2-oxoethyl]piperazin-1-yl}benzene-1-sulfonamide
CAS 2188910-51-0C18H28N4O4S