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Murcko scaffold

Ring system with 3 rings and 20 atoms

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
72
With full pages
6
Scaffold SMILES

O=C(Nc1ccc(-c2ccccc2)s1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(-c2ccccc2)s1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

2-Benzamido-5-phenylthiophene-3-carboxylic acid chemical structure, C18H13NO3S, CAS 380646-20-8
2-Benzamido-5-phenylthiophene-3-carboxylic acid
CAS 380646-20-8C18H13NO3S
2-(2-Methylbenzamido)-5-phenylthiophene-3-carboxylic acid chemical structure, C19H15NO3S, CAS 380646-25-3
2-(2-Methylbenzamido)-5-phenylthiophene-3-carboxylic acid
CAS 380646-25-3C19H15NO3S
2-[(2-Fluorobenzoyl)amino]-5-phenylthiophene-3-carboxylic acid chemical structure, C18H12FNO3S, CAS 380646-22-0
2-[(2-Fluorobenzoyl)amino]-5-phenylthiophene-3-carboxylic acid
CAS 380646-22-0C18H12FNO3S
2-(3-Methylbenzamido)-5-phenylthiophene-3-carboxylic acid chemical structure, C19H15NO3S, CAS 380646-24-2
2-(3-Methylbenzamido)-5-phenylthiophene-3-carboxylic acid
CAS 380646-24-2C19H15NO3S
2-[(4-Methylbenzoyl)amino]-5-phenylthiophene-3-carboxylic acid chemical structure, C19H15NO3S, CAS 380646-23-1
2-[(4-Methylbenzoyl)amino]-5-phenylthiophene-3-carboxylic acid
CAS 380646-23-1C19H15NO3S
Methyl 2-[(3-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C19H14N2O5S, CAS 444998-74-7
Methyl 2-[(3-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 444998-74-7C19H14N2O5S
Methyl 2-[(4-ethoxybenzoyl)amino]-5-phenyl-3-thiophenecarboxylate chemical structure, C21H19NO4S, CAS 495386-19-1
Methyl 2-[(4-ethoxybenzoyl)amino]-5-phenyl-3-thiophenecarboxylate
CAS 495386-19-1C21H19NO4S
Ethyl 2-({2-nitrobenzoyl}amino)-5-phenylthiophene-3-carboxylate chemical structure, C20H16N2O5S, CAS 445008-55-9
Ethyl 2-({2-nitrobenzoyl}amino)-5-phenylthiophene-3-carboxylate
CAS 445008-55-9C20H16N2O5S
Methyl 2-[(2-methyl-3-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C20H16N2O5S, CAS 445013-85-4
Methyl 2-[(2-methyl-3-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 445013-85-4C20H16N2O5S
Ethyl 2-[(3,4-dimethoxybenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C22H21NO5S, CAS 307536-26-1
Ethyl 2-[(3,4-dimethoxybenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 307536-26-1C22H21NO5S
Ethyl 2-[(2-methylbenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C21H19NO3S, CAS 380646-12-8
Ethyl 2-[(2-methylbenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 380646-12-8C21H19NO3S
Methyl 2-[[4-(difluoromethoxy)benzoyl]amino]-5-phenylthiophene-3-carboxylate chemical structure, C20H15F2NO4S, CAS 379245-62-2
Methyl 2-[[4-(difluoromethoxy)benzoyl]amino]-5-phenylthiophene-3-carboxylate
CAS 379245-62-2C20H15F2NO4S
Ethyl 2-(4-nitrobenzamido)-5-phenylthiophene-3-carboxylate chemical structure, C20H16N2O5S, CAS 307536-20-5
Ethyl 2-(4-nitrobenzamido)-5-phenylthiophene-3-carboxylate
CAS 307536-20-5C20H16N2O5S
2-(4-Methoxybenzamido)-5-phenylthiophene-3-carboxamide chemical structure, C19H16N2O3S, CAS 383380-01-6
2-(4-Methoxybenzamido)-5-phenylthiophene-3-carboxamide
CAS 383380-01-6C19H16N2O3S
Ethyl 2-[(3,5-dimethoxybenzoyl)amino]-5-phenyl-3-thiophenecarboxylate chemical structure, C22H21NO5S, CAS 433690-36-9
Ethyl 2-[(3,5-dimethoxybenzoyl)amino]-5-phenyl-3-thiophenecarboxylate
CAS 433690-36-9C22H21NO5S
Ethyl 2-benzamido-5-phenylthiophene-3-carboxylate chemical structure, C20H17NO3S, CAS 380646-06-0
Ethyl 2-benzamido-5-phenylthiophene-3-carboxylate
CAS 380646-06-0C20H17NO3S
2-(2-Methoxybenzamido)-5-phenylthiophene-3-carboxylic acid chemical structure, C19H15NO4S, CAS 4421-89-0
2-(2-Methoxybenzamido)-5-phenylthiophene-3-carboxylic acid
CAS 4421-89-0C19H15NO4S
2-[(2-Chlorobenzoyl)amino]-5-phenylthiophene-3-carboxylic acid chemical structure, C18H12ClNO3S, CAS 380646-26-4
2-[(2-Chlorobenzoyl)amino]-5-phenylthiophene-3-carboxylic acid
CAS 380646-26-4C18H12ClNO3S
Ethyl 2-(4-chlorobenzamido)-5-phenylthiophene-3-carboxylate chemical structure, C20H16ClNO3S, CAS 379244-81-2
Ethyl 2-(4-chlorobenzamido)-5-phenylthiophene-3-carboxylate
CAS 379244-81-2C20H16ClNO3S
Ethyl 2-[(4-bromobenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C20H16BrNO3S, CAS 307536-19-2
Ethyl 2-[(4-bromobenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 307536-19-2C20H16BrNO3S
Ethyl 2-[(2-bromobenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C20H16BrNO3S, CAS 380646-07-1
Ethyl 2-[(2-bromobenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 380646-07-1C20H16BrNO3S
Ethyl 2-(2,4-dichlorobenzamido)-5-phenylthiophene-3-carboxylate chemical structure, C20H15Cl2NO3S, CAS 307536-24-9
Ethyl 2-(2,4-dichlorobenzamido)-5-phenylthiophene-3-carboxylate
CAS 307536-24-9C20H15Cl2NO3S
Ethyl 2-[(2-chloro-4-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate chemical structure, C20H15ClN2O5S, CAS 307536-25-0
Ethyl 2-[(2-chloro-4-nitrobenzoyl)amino]-5-phenylthiophene-3-carboxylate
CAS 307536-25-0C20H15ClN2O5S
Ethyl 2-[(3,4-dimethylphenyl)carbonylamino]-5-phenylthiophene-3-carboxylate chemical structure, C22H21NO3S, CAS 433962-24-4
Ethyl 2-[(3,4-dimethylphenyl)carbonylamino]-5-phenylthiophene-3-carboxylate
CAS 433962-24-4C22H21NO3S