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Murcko scaffold

Ring system with 3 rings and 19 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
32
With full pages
8
Scaffold SMILES

O=C(c1ccn[nH]1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccn[nH]1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

(4-Iodo-2-methylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C16H19IN4O2, CAS 491831-95-9
(4-Iodo-2-methylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 491831-95-9C16H19IN4O2
(1-Methyl-1H-pyrazol-5-yl)(4-phenylpiperazin-1-yl)methanone chemical structure, C15H18N4O, CAS 489406-26-0
(1-Methyl-1H-pyrazol-5-yl)(4-phenylpiperazin-1-yl)methanone
CAS 489406-26-0C15H18N4O
[4-(4-Fluorophenyl)-1-piperazinyl]-(2-methyl-3-pyrazolyl)methanone chemical structure, C15H17FN4O, CAS 955572-49-3
[4-(4-Fluorophenyl)-1-piperazinyl]-(2-methyl-3-pyrazolyl)methanone
CAS 955572-49-3C15H17FN4O
[4-(4-Chlorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C15H17ClN4O, CAS 514220-99-6
[4-(4-Chlorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 514220-99-6C15H17ClN4O
(2,5-Dimethyl-4-nitropyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C17H18F3N5O3, CAS 514800-15-8
(2,5-Dimethyl-4-nitropyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 514800-15-8C17H18F3N5O3
(4-Chloro-2,5-dimethylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C17H18ClF3N4O, CAS 1005640-72-1
(4-Chloro-2,5-dimethylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 1005640-72-1C17H18ClF3N4O
1-[4-[4-(4-Nitro-1H-pyrazole-5-carbonyl)piperazin-1-yl]phenyl]ethanone chemical structure, C16H17N5O4, CAS 1005592-10-8
1-[4-[4-(4-Nitro-1H-pyrazole-5-carbonyl)piperazin-1-yl]phenyl]ethanone
CAS 1005592-10-8C16H17N5O4
(4-Chloro-2-methylpyrazol-3-yl)-(4-phenylpiperazin-1-yl)methanone chemical structure, C15H17ClN4O, CAS 957479-96-8
(4-Chloro-2-methylpyrazol-3-yl)-(4-phenylpiperazin-1-yl)methanone
CAS 957479-96-8C15H17ClN4O
(1-Ethylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C17H22N4O2, CAS 957513-74-5
(1-Ethylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 957513-74-5C17H22N4O2
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C17H22N4O, CAS 957480-10-3
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 957480-10-3C17H22N4O
[4-(3-Methoxyphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C16H20N4O2, CAS 955567-67-6
[4-(3-Methoxyphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 955567-67-6C16H20N4O2
[4-(4-Methoxyphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C16H20N4O2, CAS 957480-65-8
[4-(4-Methoxyphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 957480-65-8C16H20N4O2
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C17H21ClN4O, CAS 955572-70-0
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 955572-70-0C17H21ClN4O
(2-Methylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C16H17F3N4O, CAS 955558-50-6
(2-Methylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 955558-50-6C16H17F3N4O
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-chlorophenyl)piperazin-1-yl]methanone chemical structure, C15H16Cl2N4O, CAS 957513-63-2
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-chlorophenyl)piperazin-1-yl]methanone
CAS 957513-63-2C15H16Cl2N4O
(1-Ethyl-1H-pyrazol-3-yl)(4-phenylpiperazin-1-yl)methanone chemical structure, C16H20N4O, CAS 955552-56-4
(1-Ethyl-1H-pyrazol-3-yl)(4-phenylpiperazin-1-yl)methanone
CAS 955552-56-4C16H20N4O
(1-Ethylpyrazol-3-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C17H22N4O2, CAS 957507-21-0
(1-Ethylpyrazol-3-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 957507-21-0C17H22N4O2
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C15H17ClN4O, CAS 955552-64-4
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 955552-64-4C15H17ClN4O
(4-Chloro-2-methylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C16H16ClF3N4O, CAS 957487-55-7
(4-Chloro-2-methylpyrazol-3-yl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 957487-55-7C16H16ClF3N4O
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C16H19ClN4O2, CAS 955559-04-3
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 955559-04-3C16H19ClN4O2
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C15H17FN4O, CAS 955572-88-0
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 955572-88-0C15H17FN4O
[4-(2-Methylphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone chemical structure, C16H20N4O, CAS 955552-67-7
[4-(2-Methylphenyl)piperazin-1-yl]-(2-methylpyrazol-3-yl)methanone
CAS 955552-67-7C16H20N4O
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C15H16ClFN4O, CAS 957510-30-4
(4-Chloro-2-methylpyrazol-3-yl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 957510-30-4C15H16ClFN4O
(4-Chloro-2-methylpyrazol-3-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C16H19ClN4O2, CAS 955573-60-1
(4-Chloro-2-methylpyrazol-3-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone
CAS 955573-60-1C16H19ClN4O2