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Murcko scaffold

Ring system with 3 rings and 18 atoms

106 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
106
With full pages
17
Scaffold SMILES

c1ccc(N2CCN(Cc3ccco3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(Cc3ccco3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 106 chemicals

1-(2-Fluorophenyl)-4-(furan-2-ylmethyl)piperazine chemical structure, C15H17FN2O, CAS 414885-92-0
1-(2-Fluorophenyl)-4-(furan-2-ylmethyl)piperazine
CAS 414885-92-0C15H17FN2O
1-[(5-Methylfuran-2-yl)methyl]-4-phenylpiperazine chemical structure, C16H20N2O, CAS 65385-84-4
1-[(5-Methylfuran-2-yl)methyl]-4-phenylpiperazine
CAS 65385-84-4C16H20N2O
1-(2-Chlorophenyl)-4-(furan-2-ylmethyl)piperazine chemical structure, C15H17ClN2O, CAS 5270-76-8
1-(2-Chlorophenyl)-4-(furan-2-ylmethyl)piperazine
CAS 5270-76-8C15H17ClN2O
1-(2-Fluorophenyl)-4-[(5-nitrofuran-2-yl)methyl]piperazine chemical structure, C15H16FN3O3, CAS 5260-53-7
1-(2-Fluorophenyl)-4-[(5-nitrofuran-2-yl)methyl]piperazine
CAS 5260-53-7C15H16FN3O3
1-[(5-Bromofuran-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C16H16BrF3N2O, CAS 376603-47-3
1-[(5-Bromofuran-2-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 376603-47-3C16H16BrF3N2O
1-[(5-Nitro-2-furyl)methyl]-4-(4-nitrophenyl)piperazine oxalate chemical structure, C17H18N4O9, CAS 1185709-64-1
1-[(5-Nitro-2-furyl)methyl]-4-(4-nitrophenyl)piperazine oxalate
CAS 1185709-64-1C17H18N4O9
N-(2-(4-(2-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)ethanesulfonamide chemical structure, C18H24FN3O3S, CAS 877648-50-5
N-(2-(4-(2-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)ethanesulfonamide
CAS 877648-50-5C18H24FN3O3S
N-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)ethanesulfonamide chemical structure, C18H24FN3O3S, CAS 877648-29-8
N-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)ethanesulfonamide
CAS 877648-29-8C18H24FN3O3S
Methyl (2-(4-(4-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)carbamate chemical structure, C18H22FN3O3, CAS 877632-76-3
Methyl (2-(4-(4-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)carbamate
CAS 877632-76-3C18H22FN3O3
N-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)methanesulfonamide chemical structure, C17H22FN3O3S, CAS 877648-24-3
N-(2-(4-(4-Fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)methanesulfonamide
CAS 877648-24-3C17H22FN3O3S
N-(2-(Furan-2-yl)-2-(4-phenylpiperazin-1-yl)ethyl)ethanesulfonamide chemical structure, C18H25N3O3S, CAS 877648-14-1
N-(2-(Furan-2-yl)-2-(4-phenylpiperazin-1-yl)ethyl)ethanesulfonamide
CAS 877648-14-1C18H25N3O3S
N-[2-(Furan-2-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]methanesulfonamide chemical structure, C18H25N3O4S, CAS 877648-89-0
N-[2-(Furan-2-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]methanesulfonamide
CAS 877648-89-0C18H25N3O4S
Methyl (2-(furan-2-yl)-2-(4-phenylpiperazin-1-yl)ethyl)carbamate chemical structure, C18H23N3O3, CAS 887217-96-1
Methyl (2-(furan-2-yl)-2-(4-phenylpiperazin-1-yl)ethyl)carbamate
CAS 887217-96-1C18H23N3O3
Methyl (2-(furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)carbamate chemical structure, C19H25N3O4, CAS 877647-87-5
Methyl (2-(furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)carbamate
CAS 877647-87-5C19H25N3O4
N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)pivalamide chemical structure, C22H31N3O3, CAS 877634-08-7
N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)pivalamide
CAS 877634-08-7C22H31N3O3
N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)propionamide chemical structure, C20H27N3O3, CAS 877647-68-2
N-(2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)propionamide
CAS 877647-68-2C20H27N3O3
N-[2-(Furan-2-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]acetamide chemical structure, C19H25N3O3, CAS 877647-58-0
N-[2-(Furan-2-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]acetamide
CAS 877647-58-0C19H25N3O3
2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethanamine chemical structure, C17H23N3O2, CAS 927991-98-8
2-(Furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethanamine
CAS 927991-98-8C17H23N3O2
2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(furan-2-yl)ethan-1-amine chemical structure, C16H20FN3O, CAS 928000-11-7
2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(furan-2-yl)ethan-1-amine
CAS 928000-11-7C16H20FN3O
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-(2-methoxyethyl)oxalamide chemical structure, C21H27FN4O4, CAS 877632-88-7
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-(2-methoxyethyl)oxalamide
CAS 877632-88-7C21H27FN4O4
N1-(2,2-dimethoxyethyl)-N2-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)oxalamide chemical structure, C22H29FN4O5, CAS 877633-03-9
N1-(2,2-dimethoxyethyl)-N2-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)oxalamide
CAS 877633-03-9C22H29FN4O5
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-(3-methoxypropyl)oxalamide chemical structure, C22H29FN4O4, CAS 877633-19-7
N1-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-(furan-2-yl)ethyl)-N2-(3-methoxypropyl)oxalamide
CAS 877633-19-7C22H29FN4O4
N-(2,2-Diethoxyethyl)-N'-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-(furan-2-yl)ethyl}ethanediamide chemical structure, C24H33FN4O5, CAS 877633-26-6
N-(2,2-Diethoxyethyl)-N'-{2-[4-(2-fluorophenyl)piperazin-1-yl]-2-(furan-2-yl)ethyl}ethanediamide
CAS 877633-26-6C24H33FN4O5
N1-butyl-N2-(2-(furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)oxalamide chemical structure, C23H32N4O4, CAS 877633-64-2
N1-butyl-N2-(2-(furan-2-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)oxalamide
CAS 877633-64-2C23H32N4O4