Murcko scaffold
Ring system with 3 rings and 20 atoms
34 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 34
- With full pages
- 6
Scaffold SMILES
O=S(=O)(c1ccsc1)N1CCN(c2ccccc2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 34 of 34 chemicals
![Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C18H22N2O4S2, CAS 895262-16-5](/s/YORRJCWSVVMQGV-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,4-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-16-5C18H22N2O4S2
![Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C16H17FN2O4S2, CAS 895262-93-8](/s/HXEPYIUDEIYUHQ-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-93-8C16H17FN2O4S2
![Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C18H22N2O4S2, CAS 895262-99-4](/s/ZONISTFUZMAWBM-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,3-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-99-4C18H22N2O4S2
![Methyl 3-{[4-(2-methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C17H20N2O5S2, CAS 895262-51-8](/s/ACLLVHHOEMJASR-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2-methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-51-8C17H20N2O5S2
![Methyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C16H17FN2O4S2, CAS 439932-69-1](/s/XFACNBBXJDVJLD-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 439932-69-1C16H17FN2O4S2
![Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C18H22N2O4S2, CAS 895262-86-9](/s/UAMRWWWSCFTKKY-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-86-9C18H22N2O4S2
![4-{[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide chemical structure, C16H19N3O4S2, CAS 892428-08-9](/s/IARQYYFOFXXBBO-UHFFFAOYSA-N.svg)
4-{[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide
CAS 892428-08-9C16H19N3O4S2
![Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C18H20N2O5S2, CAS 895262-72-3](/s/MUUFJRLBMPNING-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-72-3C18H20N2O5S2
![Methyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C18H22N2O4S2, CAS 439932-62-4](/s/DIJGVIJEQHJNMN-UHFFFAOYSA-N.svg)
Methyl 3-{[3-methyl-4-(3-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 439932-62-4C18H22N2O4S2
![Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C17H19ClN2O4S2, CAS 895263-11-3](/s/ARYBVMMZNAFURV-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895263-11-3C17H19ClN2O4S2
![Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C17H20N2O5S2, CAS 438622-76-5](/s/DXAPKMCPNNKCFE-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 438622-76-5C17H20N2O5S2
![Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate chemical structure, C16H17ClN2O4S2, CAS 895262-30-3](/s/BLFCBVLPZSJFRN-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(3-chlorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylate
CAS 895262-30-3C16H17ClN2O4S2
![3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-(2-methylpropyl)thiophene-2-carboxamide chemical structure, C19H24ClN3O3S2, CAS 1040677-21-1](/s/QAMKOPSLEHLSIQ-UHFFFAOYSA-N.svg)
3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-(2-methylpropyl)thiophene-2-carboxamide
CAS 1040677-21-1C19H24ClN3O3S2
![3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-methylthiophene-2-carboxamide chemical structure, C18H23N3O3S2, CAS 1040632-99-2](/s/IJAMMWBXMFSUQP-UHFFFAOYSA-N.svg)
3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-methylthiophene-2-carboxamide
CAS 1040632-99-2C18H23N3O3S2
![N-Butyl-3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide chemical structure, C21H29N3O3S2, CAS 1040633-09-7](/s/WCCRUQXFGHCEIO-UHFFFAOYSA-N.svg)
N-Butyl-3-{[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide
CAS 1040633-09-7C21H29N3O3S2
![3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-(2-methylpropyl)thiophene-2-carboxamide chemical structure, C21H29N3O3S2, CAS 1040633-14-4](/s/WBLBLXHDOQDKRJ-UHFFFAOYSA-N.svg)
3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-(2-methylpropyl)thiophene-2-carboxamide
CAS 1040633-14-4C21H29N3O3S2
![3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-ethylthiophene-2-carboxamide chemical structure, C17H20ClN3O3S2, CAS 1040635-15-1](/s/WLVGLEBSNWDMSR-UHFFFAOYSA-N.svg)
3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-ethylthiophene-2-carboxamide
CAS 1040635-15-1C17H20ClN3O3S2
![3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide chemical structure, C20H26ClN3O3S2, CAS 1040635-23-1](/s/NYLLLQUSMADEDN-UHFFFAOYSA-N.svg)
3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide
CAS 1040635-23-1C20H26ClN3O3S2
![N-Pentyl-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxamide chemical structure, C20H27N3O3S2, CAS 1040640-49-0](/s/GYRRNRBVCMLFCG-UHFFFAOYSA-N.svg)
N-Pentyl-3-[(4-phenylpiperazin-1-yl)sulfonyl]thiophene-2-carboxamide
CAS 1040640-49-0C20H27N3O3S2
![3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide chemical structure, C22H31N3O3S2, CAS 1040641-60-8](/s/LUIYFDGGOMBTKE-UHFFFAOYSA-N.svg)
3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide
CAS 1040641-60-8C22H31N3O3S2
N-(sec-Butyl)-3-((4-phenylpiperazin-1-yl)sulfonyl)thiophene-2-carboxamide
CAS 1040671-29-1C19H25N3O3S2
![N-(Butan-2-yl)-3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide chemical structure, C19H24FN3O3S2, CAS 1040654-47-4](/s/IHNYUCLOPFWDBZ-UHFFFAOYSA-N.svg)
N-(Butan-2-yl)-3-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide
CAS 1040654-47-4C19H24FN3O3S2
![N-Methyl-3-{[4-(3-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide chemical structure, C17H21N3O3S2, CAS 1207036-71-2](/s/JQQNHWPVOWRPKX-UHFFFAOYSA-N.svg)
N-Methyl-3-{[4-(3-methylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide
CAS 1207036-71-2C17H21N3O3S2
![3-{[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-ethylthiophene-2-carboxamide chemical structure, C17H20ClN3O3S2, CAS 1207048-55-2](/s/WKEFRSQXHDKISB-UHFFFAOYSA-N.svg)
3-{[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-ethylthiophene-2-carboxamide
CAS 1207048-55-2C17H20ClN3O3S2
- 3-{[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide1207057-43-9C20H26ClN3O3S2
- 3-{[4-(3-Methylphenyl)piperazin-1-yl]sulfonyl}-N-(2-methylpropyl)thiophene-2-carboxamide1207027-88-0C20H27N3O3S2
- 3-{[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl}-N-(propan-2-yl)thiophene-2-carboxamide1207035-20-8C19H25N3O4S2
- 3-{[4-(4-Methoxyphenyl)piperazin-1-yl]sulfonyl}-N-pentylthiophene-2-carboxamide1207006-72-1C21H29N3O4S2
- 3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}-N-propylthiophene-2-carboxamide1207042-41-8C20H27N3O3S2
- 3-{[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl}-N-propylthiophene-2-carboxamide1206994-91-3C18H22ClN3O3S2
- N-Isobutyl-3-((4-(3-methoxyphenyl)piperazin-1-yl)sulfonyl)thiophene-2-carboxamide1251593-07-3C20H27N3O4S2
- N-Butyl-3-{[4-(3-methoxyphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide1251676-29-5C20H27N3O4S2
- 3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxylic acid1325303-47-6C17H20N2O4S2
- 3-{[4-(2,5-Dimethylphenyl)piperazin-1-yl]sulfonyl}thiophene-2-carboxamide1357842-49-9C17H21N3O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1cccs1)N1CCN(c2ccccc2)CC118 chemicals
c1ccc(N2CCN(Cc3ccco3)CC2)cc117 chemicals
O=C(c1ccco1)N1CCN(c2ccccc2)CC112 chemicals
O=S(=O)(c1cccs1)N1CCN(c2ccccc2)CC110 chemicals![Scaffold O=C(c1ccn[nH]1)N1CCN(c2ccccc2)CC1](/scaffold/BKNYUNUITJNLKX-UHFFFAOYSA-N/structure.svg)
O=C(c1ccn[nH]1)N1CCN(c2ccccc2)CC18 chemicals
O=C(c1cnoc1)N1CCN(c2ccccc2)CC16 chemicals
c1ccc(-c2ccc(Cn3ccnc3)cc2)cc15 chemicals![Scaffold O=C(c1ccc[nH]1)N1CCN(c2ccccc2)CC1](/scaffold/OICPROFNJBYILR-UHFFFAOYSA-N/structure.svg)
O=C(c1ccc[nH]1)N1CCN(c2ccccc2)CC15 chemicals![Scaffold O=S(=O)(c1cn[nH]c1)N1CCN(c2ccccc2)CC1](/scaffold/YZJIISOXZVBLPB-UHFFFAOYSA-N/structure.svg)
O=S(=O)(c1cn[nH]c1)N1CCN(c2ccccc2)CC15 chemicals
O=C(c1ccoc1)N1CCN(c2ccccc2)CC14 chemicals
O=C(C1CCCO1)N1CCN(c2ccccc2)CC13 chemicals
C1=CN(Cc2cccs2)C=CC1c1ccccc13 chemicals