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Murcko scaffold

1-Phenyl-4-(2-thienylsulfonyl)piperazine scaffold

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
26
With full pages
10
Scaffold SMILES

O=S(=O)(c1cccs1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-4-(2-thienylsulfonyl)piperazine page
Murcko scaffold O=S(=O)(c1cccs1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

1-(5-Bromothiophen-2-yl)sulfonyl-4-(4-methoxyphenyl)piperazine chemical structure, C15H17BrN2O3S2, CAS 573936-74-0
1-(5-Bromothiophen-2-yl)sulfonyl-4-(4-methoxyphenyl)piperazine
CAS 573936-74-0C15H17BrN2O3S2
1-(4-Methoxyphenyl)-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H18N2O3S2, CAS 488102-33-6
1-(4-Methoxyphenyl)-4-thiophen-2-ylsulfonylpiperazine
CAS 488102-33-6C15H18N2O3S2
1-Phenyl-4-(2-thienylsulfonyl)piperazine chemical structure, C14H16N2O2S2, CAS 324779-57-9
1-Phenyl-4-(2-thienylsulfonyl)piperazine
CAS 324779-57-9C14H16N2O2S2
1-(2-Methoxyphenyl)-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H18N2O3S2, CAS 354128-92-0
1-(2-Methoxyphenyl)-4-thiophen-2-ylsulfonylpiperazine
CAS 354128-92-0C15H18N2O3S2
1-(4-Fluoro-phenyl)-4-(thiophene-2-sulfonyl)-piperazine chemical structure, C14H15FN2O2S2, CAS 439932-72-6
1-(4-Fluoro-phenyl)-4-(thiophene-2-sulfonyl)-piperazine
CAS 439932-72-6C14H15FN2O2S2
1-(3-Chloro-phenyl)-4-(thiophene-2-sulfonyl)-piperazine chemical structure, C14H15ClN2O2S2, CAS 439935-37-2
1-(3-Chloro-phenyl)-4-(thiophene-2-sulfonyl)-piperazine
CAS 439935-37-2C14H15ClN2O2S2
1-(5-Bromothiophen-2-yl)sulfonyl-4-(3-chlorophenyl)piperazine chemical structure, C14H14BrClN2O2S2, CAS 438236-73-8
1-(5-Bromothiophen-2-yl)sulfonyl-4-(3-chlorophenyl)piperazine
CAS 438236-73-8C14H14BrClN2O2S2
1-(3-Chlorophenyl)-4-(5-chlorothiophen-2-yl)sulfonylpiperazine chemical structure, C14H14Cl2N2O2S2, CAS 452077-36-0
1-(3-Chlorophenyl)-4-(5-chlorothiophen-2-yl)sulfonylpiperazine
CAS 452077-36-0C14H14Cl2N2O2S2
5-Chloro-2-{[4-(4-methoxyphenyl)piperazinyl]sulfonyl}thiophene chemical structure, C15H17ClN2O3S2, CAS 452077-40-6
5-Chloro-2-{[4-(4-methoxyphenyl)piperazinyl]sulfonyl}thiophene
CAS 452077-40-6C15H17ClN2O3S2
1-(Thien-2-ylsulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C15H15F3N2O2S2, CAS 307511-78-0
1-(Thien-2-ylsulfonyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 307511-78-0C15H15F3N2O2S2
1-(5-Bromothiophen-2-yl)sulfonyl-4-(2-methoxyphenyl)piperazine chemical structure, C15H17BrN2O3S2, CAS 439935-38-3
1-(5-Bromothiophen-2-yl)sulfonyl-4-(2-methoxyphenyl)piperazine
CAS 439935-38-3C15H17BrN2O3S2
1-[(5-Bromo-2-thienyl)sulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C14H14BrFN2O2S2, CAS 81597-65-1
1-[(5-Bromo-2-thienyl)sulfonyl]-4-(4-fluorophenyl)piperazine
CAS 81597-65-1C14H14BrFN2O2S2
1-[4-Nitro-2-(trifluoromethyl)phenyl]-4-thiophen-2-ylsulfonylpiperazine chemical structure, C15H14F3N3O4S2, CAS 714206-06-1
1-[4-Nitro-2-(trifluoromethyl)phenyl]-4-thiophen-2-ylsulfonylpiperazine
CAS 714206-06-1C15H14F3N3O4S2
5-[4-(5-Bromothiophen-2-yl)sulfonylpiperazin-1-yl]-N-methyl-2-nitroaniline chemical structure, C15H17BrN4O4S2, CAS 718602-33-6
5-[4-(5-Bromothiophen-2-yl)sulfonylpiperazin-1-yl]-N-methyl-2-nitroaniline
CAS 718602-33-6C15H17BrN4O4S2
1-(5-Bromothiophen-2-yl)sulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C15H13BrF3N3O4S2, CAS 718603-46-4
1-(5-Bromothiophen-2-yl)sulfonyl-4-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 718603-46-4C15H13BrF3N3O4S2
5-[4-(5-Chlorothiophen-2-yl)sulfonylpiperazin-1-yl]-N-ethyl-2-nitroaniline chemical structure, C16H19ClN4O4S2, CAS 774549-67-6
5-[4-(5-Chlorothiophen-2-yl)sulfonylpiperazin-1-yl]-N-ethyl-2-nitroaniline
CAS 774549-67-6C16H19ClN4O4S2
Dimethyl 3-methyl-5-(4-phenylpiperazin-1-yl)sulfonylthiophene-2,4-dicarboxylate chemical structure, C19H22N2O6S2, CAS 612044-97-0
Dimethyl 3-methyl-5-(4-phenylpiperazin-1-yl)sulfonylthiophene-2,4-dicarboxylate
CAS 612044-97-0C19H22N2O6S2
2-Methyl-1-(4-methylphenyl)-4-thiophen-2-ylsulfonylpiperazine chemical structure, C16H20N2O2S2, CAS 439932-58-8
2-Methyl-1-(4-methylphenyl)-4-thiophen-2-ylsulfonylpiperazine
CAS 439932-58-8C16H20N2O2S2
Dimethyl 5-((4-(2-methoxyphenyl)piperazin-1-yl)sulfonyl)-3-methylthiophene-2,4-dicarboxylate chemical structure, C20H24N2O7S2, CAS 612044-99-2
Dimethyl 5-((4-(2-methoxyphenyl)piperazin-1-yl)sulfonyl)-3-methylthiophene-2,4-dicarboxylate
CAS 612044-99-2C20H24N2O7S2
3-Nitro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide chemical structure, C15H16N4O5S2, CAS 790242-83-0
3-Nitro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide
CAS 790242-83-0C15H16N4O5S2
1-(5-Chlorothiophen-2-yl)sulfonyl-4-(2-fluorophenyl)piperazine chemical structure, C14H14ClFN2O2S2, CAS 452077-42-8
1-(5-Chlorothiophen-2-yl)sulfonyl-4-(2-fluorophenyl)piperazine
CAS 452077-42-8C14H14ClFN2O2S2
Dimethyl 5-[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl-3-methylthiophene-2,4-dicarboxylate chemical structure, C19H21FN2O6S2, CAS 920821-00-7
Dimethyl 5-[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl-3-methylthiophene-2,4-dicarboxylate
CAS 920821-00-7C19H21FN2O6S2
4-[4-[(5-Amino-2-thienyl)sulfonyl]-1-piperazinyl]-I+/-,I+/--bis(trifluoromethyl)benzenemethanol chemical structure, C17H17F6N3O3S2, CAS 1361219-04-6
4-[4-[(5-Amino-2-thienyl)sulfonyl]-1-piperazinyl]-I+/-,I+/--bis(trifluoromethyl)benzenemethanol
CAS 1361219-04-6C17H17F6N3O3S2
1-[(5-Fluoro-2-thienyl)sulfonyl]-4-phenylpiperazine chemical structure, C14H15FN2O2S2, CAS 1855900-12-7
1-[(5-Fluoro-2-thienyl)sulfonyl]-4-phenylpiperazine
CAS 1855900-12-7C14H15FN2O2S2