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Murcko scaffold

Ring system with 3 rings and 19 atoms

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
29
With full pages
6
Scaffold SMILES

O=C(c1cnoc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cnoc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

Methanone, [4-(3,4-dichlorophenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)- chemical structure, C17H19Cl2N3O2, CAS 775300-07-7
Methanone, [4-(3,4-dichlorophenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)-
CAS 775300-07-7C17H19Cl2N3O2
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2-ethoxyphenyl)-1-piperazinyl]- chemical structure, C18H23N3O3, CAS 717872-74-7
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2-ethoxyphenyl)-1-piperazinyl]-
CAS 717872-74-7C18H23N3O3
(3,5-Dimethyl-4-isoxazolyl)(4-phenylpiperazino)methanone chemical structure, C16H19N3O2, CAS 478031-52-6
(3,5-Dimethyl-4-isoxazolyl)(4-phenylpiperazino)methanone
CAS 478031-52-6C16H19N3O2
(4-(3-Chlorophenyl)piperazino)(3,5-dimethyl-4-isoxazolyl)methanone chemical structure, C16H18ClN3O2, CAS 478031-57-1
(4-(3-Chlorophenyl)piperazino)(3,5-dimethyl-4-isoxazolyl)methanone
CAS 478031-57-1C16H18ClN3O2
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2-fluorophenyl)-1-piperazinyl]- chemical structure, C16H18FN3O2, CAS 849183-31-9
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2-fluorophenyl)-1-piperazinyl]-
CAS 849183-31-9C16H18FN3O2
Methanone, [4-(2-chlorophenyl)-1-piperazinyl](3,5-dimethyl-4-isoxazolyl)- chemical structure, C16H18ClN3O2, CAS 849478-04-2
Methanone, [4-(2-chlorophenyl)-1-piperazinyl](3,5-dimethyl-4-isoxazolyl)-
CAS 849478-04-2C16H18ClN3O2
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2,3-dimethylphenyl)-1-piperazinyl]- chemical structure, C18H23N3O2, CAS 850183-33-4
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(2,3-dimethylphenyl)-1-piperazinyl]-
CAS 850183-33-4C18H23N3O2
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(3-methoxyphenyl)-1-piperazinyl]- chemical structure, C17H21N3O3, CAS 850215-28-0
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(3-methoxyphenyl)-1-piperazinyl]-
CAS 850215-28-0C17H21N3O3
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-[2-nitro-4-(trifluoromethyl)phenyl]-1-piperazinyl]- chemical structure, C17H17F3N4O4, CAS 866789-39-1
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-[2-nitro-4-(trifluoromethyl)phenyl]-1-piperazinyl]-
CAS 866789-39-1C17H17F3N4O4
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-nitrophenyl)-1-piperazinyl]- chemical structure, C17H20N4O4, CAS 1031179-46-0
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-nitrophenyl)-1-piperazinyl]-
CAS 1031179-46-0C17H20N4O4
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-fluorophenyl)-1-piperazinyl]- chemical structure, C17H20FN3O2, CAS 925147-88-2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-fluorophenyl)-1-piperazinyl]-
CAS 925147-88-2C17H20FN3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(2-methylphenyl)-1-piperazinyl]- chemical structure, C18H23N3O2, CAS 959243-57-3
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(2-methylphenyl)-1-piperazinyl]-
CAS 959243-57-3C18H23N3O2
Methanone, [4-(2,3-dimethylphenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)- chemical structure, C19H25N3O2, CAS 923736-75-8
Methanone, [4-(2,3-dimethylphenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)-
CAS 923736-75-8C19H25N3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-methoxyphenyl)-1-piperazinyl]- chemical structure, C18H23N3O3, CAS 932876-24-9
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(4-methoxyphenyl)-1-piperazinyl]-
CAS 932876-24-9C18H23N3O3
Methanone, [4-(5-chloro-2-methylphenyl)-1-piperazinyl][3-methyl-5-(1-methylethyl)-4-isoxazolyl]- chemical structure, C19H24ClN3O2, CAS 930751-54-5
Methanone, [4-(5-chloro-2-methylphenyl)-1-piperazinyl][3-methyl-5-(1-methylethyl)-4-isoxazolyl]-
CAS 930751-54-5C19H24ClN3O2
Methanone, [4-(5-chloro-2-methylphenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)- chemical structure, C18H22ClN3O2, CAS 932789-49-6
Methanone, [4-(5-chloro-2-methylphenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)-
CAS 932789-49-6C18H22ClN3O2
Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)- chemical structure, C17H20ClN3O2, CAS 925155-72-2
Methanone, [4-(3-chlorophenyl)-1-piperazinyl](3-ethyl-5-methyl-4-isoxazolyl)-
CAS 925155-72-2C17H20ClN3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)(4-phenyl-1-piperazinyl)- chemical structure, C17H21N3O2, CAS 925663-15-6
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)(4-phenyl-1-piperazinyl)-
CAS 925663-15-6C17H21N3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]- chemical structure, C18H20F3N3O2, CAS 932854-69-8
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-
CAS 932854-69-8C18H20F3N3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(2-fluorophenyl)-1-piperazinyl]- chemical structure, C17H20FN3O2, CAS 932813-53-1
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(2-fluorophenyl)-1-piperazinyl]-
CAS 932813-53-1C17H20FN3O2
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(4-fluorophenyl)-1-piperazinyl]- chemical structure, C16H18FN3O2, CAS 945201-72-9
Methanone, (3,5-dimethyl-4-isoxazolyl)[4-(4-fluorophenyl)-1-piperazinyl]-
CAS 945201-72-9C16H18FN3O2
Methanone, [4-(4-chlorophenyl)-1-piperazinyl](3,5-dimethyl-4-isoxazolyl)- chemical structure, C16H18ClN3O2, CAS 945116-83-6
Methanone, [4-(4-chlorophenyl)-1-piperazinyl](3,5-dimethyl-4-isoxazolyl)-
CAS 945116-83-6C16H18ClN3O2
Methanone, [4-(3-chlorophenyl)-1-piperazinyl][3-methyl-5-(1-methylethyl)-4-isoxazolyl]- chemical structure, C18H22ClN3O2, CAS 923872-41-7
Methanone, [4-(3-chlorophenyl)-1-piperazinyl][3-methyl-5-(1-methylethyl)-4-isoxazolyl]-
CAS 923872-41-7C18H22ClN3O2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(3-methylphenyl)-1-piperazinyl]- chemical structure, C18H23N3O2, CAS 940824-78-2
Methanone, (3-ethyl-5-methyl-4-isoxazolyl)[4-(3-methylphenyl)-1-piperazinyl]-
CAS 940824-78-2C18H23N3O2