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Murcko scaffold

Piperazine, 1-phenyl-4-(2-thenoyl)- scaffold

53 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
53
With full pages
18
Scaffold SMILES

O=C(c1cccs1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-phenyl-4-(2-thenoyl)- page
Murcko scaffold O=C(c1cccs1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

Piperazine, 1-phenyl-4-(2-thenoyl)- chemical structure, C15H16N2OS, CAS 339158-52-0
Piperazine, 1-phenyl-4-(2-thenoyl)-
CAS 339158-52-0C15H16N2OS
RefChem:381349 chemical structure, C18H19FN2O2S, CAS 6039-76-5
RefChem:381349
CAS 6039-76-5C18H19FN2O2S
N-{4-[4-(Thiophene-2-carbonyl)-piperazin-1-yl]-phenyl}-butyramide chemical structure, C19H23N3O2S, CAS 672317-59-8
N-{4-[4-(Thiophene-2-carbonyl)-piperazin-1-yl]-phenyl}-butyramide
CAS 672317-59-8C19H23N3O2S
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]phenyl]acetamide chemical structure, C17H19N3O2S, CAS 671818-49-8
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]phenyl]acetamide
CAS 671818-49-8C17H19N3O2S
1-(4-Fluorophenyl)-4-(thiophene-2-carbonyl)piperazine chemical structure, C15H15FN2OS, CAS 312617-60-0
1-(4-Fluorophenyl)-4-(thiophene-2-carbonyl)piperazine
CAS 312617-60-0C15H15FN2OS
1-(2,3-Dimethylphenyl)-4-(2-thienylcarbonyl)piperazine chemical structure, C17H20N2OS, CAS 329222-45-9
1-(2,3-Dimethylphenyl)-4-(2-thienylcarbonyl)piperazine
CAS 329222-45-9C17H20N2OS
[4-(2-Fluorophenyl)piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C15H15FN2OS, CAS 432496-31-6
[4-(2-Fluorophenyl)piperazin-1-yl]-thiophen-2-ylmethanone
CAS 432496-31-6C15H15FN2OS
[4-(4-Methoxyphenyl)piperazin-1-yl](thiophen-2-yl)methanone chemical structure, C16H18N2O2S, CAS 675860-72-7
[4-(4-Methoxyphenyl)piperazin-1-yl](thiophen-2-yl)methanone
CAS 675860-72-7C16H18N2O2S
1-(2-Methoxyphenyl)-4-(thiophene-2-carbonyl)piperazine chemical structure, C16H18N2O2S, CAS 145253-76-5
1-(2-Methoxyphenyl)-4-(thiophene-2-carbonyl)piperazine
CAS 145253-76-5C16H18N2O2S
[4-(3,4-Dichlorophenyl)piperazin-1-yl](thiophen-2-yl)methanone chemical structure, C15H14Cl2N2OS, CAS 663930-16-3
[4-(3,4-Dichlorophenyl)piperazin-1-yl](thiophen-2-yl)methanone
CAS 663930-16-3C15H14Cl2N2OS
[4-(4-Chlorophenyl)piperazin-1-yl]-thiophen-2-ylmethanone chemical structure, C15H15ClN2OS, CAS 544666-71-9
[4-(4-Chlorophenyl)piperazin-1-yl]-thiophen-2-ylmethanone
CAS 544666-71-9C15H15ClN2OS
Thiophen-2-yl-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C16H15F3N2OS, CAS 433237-56-0
Thiophen-2-yl-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 433237-56-0C16H15F3N2OS
{3-Chloro-4-[4-(2-thienylcarbonyl)piperazin-1-yl]phenyl}amine chemical structure, C15H16ClN3OS, CAS 690960-62-4
{3-Chloro-4-[4-(2-thienylcarbonyl)piperazin-1-yl]phenyl}amine
CAS 690960-62-4C15H16ClN3OS
1-[4-[4-[(4,5-Dibromo-2-thienyl)carbonyl]-1-piperazinyl]phenyl]ethanone chemical structure, C17H16Br2N2O2S, CAS 438235-92-8
1-[4-[4-[(4,5-Dibromo-2-thienyl)carbonyl]-1-piperazinyl]phenyl]ethanone
CAS 438235-92-8C17H16Br2N2O2S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]butanamide chemical structure, C19H22ClN3O2S, CAS 690960-64-6
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]butanamide
CAS 690960-64-6C19H22ClN3O2S
2,2-Dimethyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]propanamide chemical structure, C20H25N3O2S, CAS 672933-74-3
2,2-Dimethyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]propanamide
CAS 672933-74-3C20H25N3O2S
{4-[4-(2-Thienylcarbonyl)piperazin-1-yl]phenyl}amine chemical structure, C15H17N3OS, CAS 412331-95-4
{4-[4-(2-Thienylcarbonyl)piperazin-1-yl]phenyl}amine
CAS 412331-95-4C15H17N3OS
(5-Ethylthiophen-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C17H19FN2OS, CAS 774588-14-6
(5-Ethylthiophen-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 774588-14-6C17H19FN2OS
(5-Bromothiophen-2-yl)(4-phenylpiperazin-1-yl)methanone chemical structure, C15H15BrN2OS, CAS 477546-35-3
(5-Bromothiophen-2-yl)(4-phenylpiperazin-1-yl)methanone
CAS 477546-35-3C15H15BrN2OS
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3-methylbutanamide chemical structure, C20H24ClN3O2S, CAS 847481-95-2
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3-methylbutanamide
CAS 847481-95-2C20H24ClN3O2S
3-Methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]butanamide chemical structure, C20H25N3O2S, CAS 674815-89-5
3-Methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]butanamide
CAS 674815-89-5C20H25N3O2S
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]phenyl]hexanamide chemical structure, C21H27N3O2S, CAS 674352-41-1
N-[4-[4-(Thiophene-2-carbonyl)piperazin-1-yl]phenyl]hexanamide
CAS 674352-41-1C21H27N3O2S
N-[[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]carbamothioyl]butanamide chemical structure, C20H23ClN4O2S2, CAS 708992-27-2
N-[[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]carbamothioyl]butanamide
CAS 708992-27-2C20H23ClN4O2S2
1-(5-Nitrothiophene-2-carbonyl)-4-phenylpiperazine chemical structure, C15H15N3O3S, CAS 477546-42-2
1-(5-Nitrothiophene-2-carbonyl)-4-phenylpiperazine
CAS 477546-42-2C15H15N3O3S