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Murcko scaffold

Ring system with 3 rings and 22 atoms

25 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 25
With full pages: 3

Scaffold SMILES

O=C1C(=CC=Cc2ccccc2)SC(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=CC=Cc2ccccc2)SC(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

3-{(5E)-4-Oxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-3-yl}benzoic acid chemical structure, C19H13NO3S2, CAS 464902-41-8

3-{(5E)-4-Oxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-3-yl}benzoic acid

CAS 464902-41-8C₁₉H₁₃NO₃S₂

(5Z)-3-(2-Methoxyphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H17NO2S2, CAS 307510-91-4

(5Z)-3-(2-Methoxyphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 307510-91-4C₂₀H₁₇NO₂S₂

(Z)-3-(4-Ethoxyphenyl)-5-((E)-2-methyl-3-phenylallylidene)-2-thioxothiazolidin-4-one chemical structure, C21H19NO2S2, CAS 5762-67-4

(Z)-3-(4-Ethoxyphenyl)-5-((E)-2-methyl-3-phenylallylidene)-2-thioxothiazolidin-4-one

CAS 5762-67-4C₂₁H₁₉NO₂S₂

(Z)-3-(4-Hydroxyphenyl)-5-((E)-2-methyl-3-phenylallylidene)-2-thioxothiazolidin-4-one chemical structure, C19H15NO2S2, CAS 307504-68-3

(Z)-3-(4-Hydroxyphenyl)-5-((E)-2-methyl-3-phenylallylidene)-2-thioxothiazolidin-4-one

CAS 307504-68-3C₁₉H₁₅NO₂S₂

(Z)-3-(2-Methoxyphenyl)-5-((E)-3-phenylallylidene)-2-thioxothiazolidin-4-one chemical structure, C19H15NO2S2, CAS 307525-26-4

(Z)-3-(2-Methoxyphenyl)-5-((E)-3-phenylallylidene)-2-thioxothiazolidin-4-one

CAS 307525-26-4C₁₉H₁₅NO₂S₂

Imb-10 chemical structure, C19H15NOS2, CAS 307525-40-2

CAS 307525-40-2C₁₉H₁₅NOS₂

(5Z)-3-(3-Chlorophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H14ClNOS2, CAS 314274-71-0

(5Z)-3-(3-Chlorophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 314274-71-0C₁₉H₁₄ClNOS₂

3-(3-Fluoro-phenyl)-5-(2-methyl-3-phenyl-allylidene)-2-thioxo-thiazolidin-4-one chemical structure, C19H14FNOS2, CAS 327054-30-8

3-(3-Fluoro-phenyl)-5-(2-methyl-3-phenyl-allylidene)-2-thioxo-thiazolidin-4-one

CAS 327054-30-8C₁₉H₁₄FNOS₂

(5Z)-3-(2,3-Dimethylphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H19NOS2, CAS 301687-27-4

(5Z)-3-(2,3-Dimethylphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 301687-27-4C₂₁H₁₉NOS₂

(E)-5-((E)-2-Methyl-3-phenylallylidene)-3-phenyl-2-thioxothiazolidin-4-one chemical structure, C19H15NOS2, CAS 312914-05-9

(E)-5-((E)-2-Methyl-3-phenylallylidene)-3-phenyl-2-thioxothiazolidin-4-one

CAS 312914-05-9C₁₉H₁₅NOS₂

(5Z)-5-[(2E)-2-Methyl-3-phenylprop-2-enylidene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one chemical structure, C20H14F3NOS2, CAS 5860-73-1

(5Z)-5-[(2E)-2-Methyl-3-phenylprop-2-enylidene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one

CAS 5860-73-1C₂₀H₁₄F₃NOS₂

(5Z)-3-(3-Methoxyphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H17NO2S2, CAS 306323-82-0

(5Z)-3-(3-Methoxyphenyl)-5-[(2E)-2-methyl-3-phenylprop-2-enylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 306323-82-0C₂₀H₁₇NO₂S₂

3-[4-(Diethylamino)phenyl]-5-(2-methyl-3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C23H24N2OS2, CAS 306324-06-1

3-[4-(Diethylamino)phenyl]-5-(2-methyl-3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolidin-4-one

CAS 306324-06-1C₂₃H₂₄N₂OS₂

(5Z)-3-(2-Bromophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H14BrNOS2, CAS 314274-75-4

(5Z)-3-(2-Bromophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 314274-75-4C₁₉H₁₄BrNOS₂

(5Z)-3-(2-Chlorophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H14ClNOS2, CAS 314274-72-1

(5Z)-3-(2-Chlorophenyl)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 314274-72-1C₁₉H₁₄ClNOS₂

4-((E)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid chemical structure, C20H15NO3S2, CAS 342046-11-1

4-((E)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid

CAS 342046-11-1C₂₀H₁₅NO₃S₂

4-[5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C20H15NO3S2, CAS 1815597-84-2

4-[5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid

CAS 1815597-84-2C₂₀H₁₅NO₃S₂

3-(4-Fluoro-phenyl)-5-(2-methyl-3-phenyl-allylidene)-2-thioxo-thiazolidin-4-one chemical structure, C19H14FNOS2, CAS 303056-41-9

3-(4-Fluoro-phenyl)-5-(2-methyl-3-phenyl-allylidene)-2-thioxo-thiazolidin-4-one

CAS 303056-41-9C₁₉H₁₄FNOS₂

3-[5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C20H15NO3S2, CAS 342046-06-4

3-[5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid

CAS 342046-06-4C₂₀H₁₅NO₃S₂

5-{3-[4-(Dimethylamino)phenyl]-2-propenylidene}-3-(3-fluorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H17FN2OS2, CAS 327054-29-5

5-{3-[4-(Dimethylamino)phenyl]-2-propenylidene}-3-(3-fluorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 327054-29-5C₂₀H₁₇FN₂OS₂

(5Z)-3-(3-Methylphenyl)-5-[(2E)-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H15NOS2, CAS 314751-82-1

(5Z)-3-(3-Methylphenyl)-5-[(2E)-3-phenylprop-2-en-1-ylidene]-2-thioxo-1,3-thiazolidin-4-one

CAS 314751-82-1C₁₉H₁₅NOS₂

(Z)-3-(3-Hydroxyphenyl)-5-((E)-3-phenylallylidene)-2-thioxothiazolidin-4-one chemical structure, C18H13NO2S2, CAS 300816-68-6

(Z)-3-(3-Hydroxyphenyl)-5-((E)-3-phenylallylidene)-2-thioxothiazolidin-4-one

CAS 300816-68-6C₁₈H₁₃NO₂S₂

3-(4-Butylphenyl)-5-(2-chloro-3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone chemical structure, C22H20ClNOS2, CAS 881823-94-5

3-(4-Butylphenyl)-5-(2-chloro-3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone

CAS 881823-94-5C₂₂H₂₀ClNOS₂

(5Z)-5-[(2E)-3-Phenylprop-2-en-1-ylidene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one chemical structure, C19H12F3NOS2, CAS 299956-03-9

(5Z)-5-[(2E)-3-Phenylprop-2-en-1-ylidene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one

CAS 299956-03-9C₁₉H₁₂F₃NOS₂

(E)-2-Methyl-3-[4-[(E,3E)-2-methyl-3-(4-oxo-3-phenyl-2-sulfanylidene-1,3-thiazolidin-5-ylidene)prop-1-enyl]phenyl]prop-2-enal
5848-15-7C₂₃H₁₉NO₂S₂