Murcko scaffold
Benzoic acid, 2-(2-thienylmethylene)hydrazide scaffold
52 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 52
- With full pages
- 7
Scaffold SMILES
O=C(NN=Cc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 52 chemicals
Benzoic acid, 2-(2-thienylmethylene)hydrazide
CAS 16371-55-4C12H10N2OS
4-Chlorobenzoic acid 2-(2-thienylmethylene)hydrazide
CAS 93418-12-3C12H9ClN2OS
![4-Aminobenzoic acid 2-[1-(2-thienyl)ethylidene]hydrazide chemical structure, C13H13N3OS, CAS 524932-94-3](/s/YDDRFTMRNJVFNQ-UHFFFAOYSA-N.svg)
4-Aminobenzoic acid 2-[1-(2-thienyl)ethylidene]hydrazide
CAS 524932-94-3C13H13N3OS
![2-({2-[(E)-(5-Nitro-2-thienyl)methylidene]hydrazino}carbonyl)benzoic acid chemical structure, C13H9N3O5S, CAS 314766-06-8](/s/WNHDKVXCIQQYPX-UHFFFAOYSA-N.svg)
2-({2-[(E)-(5-Nitro-2-thienyl)methylidene]hydrazino}carbonyl)benzoic acid
CAS 314766-06-8C13H9N3O5S
![3-Iodo-4-methoxybenzoic acid 2-[(5-nitro-2-thienyl)methylene]hydrazide chemical structure, C13H10IN3O4S, CAS 349625-21-4](/s/BKKAQCVLGSYFCZ-UHFFFAOYSA-N.svg)
3-Iodo-4-methoxybenzoic acid 2-[(5-nitro-2-thienyl)methylene]hydrazide
CAS 349625-21-4C13H10IN3O4S
![3-Hydroxy-4-iodobenzoic acid 2-[(5-chloro-2-thienyl)methylene]hydrazide chemical structure, C12H8ClIN2O2S, CAS 469901-74-4](/s/CTJCLDQXXIUXEH-UHFFFAOYSA-N.svg)
3-Hydroxy-4-iodobenzoic acid 2-[(5-chloro-2-thienyl)methylene]hydrazide
CAS 469901-74-4C12H8ClIN2O2S
![4-Methylbenzoic acid 2-[(5-chloro-2-thienyl)methylene]hydrazide chemical structure, C13H11ClN2OS, CAS 544457-78-5](/s/JNAAZGOVCUCWTP-UHFFFAOYSA-N.svg)
4-Methylbenzoic acid 2-[(5-chloro-2-thienyl)methylene]hydrazide
CAS 544457-78-5C13H11ClN2OS
![5-Chloro-N-[1-(5-chlorothiophen-2-yl)ethylideneamino]-2-methoxybenzamide chemical structure, C14H12Cl2N2O2S, CAS 6383-91-1](/s/MAOIPEZWQRXDMM-UHFFFAOYSA-N.svg)
5-Chloro-N-[1-(5-chlorothiophen-2-yl)ethylideneamino]-2-methoxybenzamide
CAS 6383-91-1C14H12Cl2N2O2S
![N'-[1-(5-Chlorothiophen-2-yl)ethylidene]-3-fluorobenzohydrazide chemical structure, C13H10ClFN2OS, CAS 6376-42-7](/s/AQMJBMWUDYJBNJ-UHFFFAOYSA-N.svg)
N'-[1-(5-Chlorothiophen-2-yl)ethylidene]-3-fluorobenzohydrazide
CAS 6376-42-7C13H10ClFN2OS
![4-Methyl-3-nitrobenzoic acid 2-[1-(5-bromo-2-thienyl)ethylidene]hydrazide chemical structure, C14H12BrN3O3S, CAS 544662-11-5](/s/LNLBHLMFWYMDGK-UHFFFAOYSA-N.svg)
4-Methyl-3-nitrobenzoic acid 2-[1-(5-bromo-2-thienyl)ethylidene]hydrazide
CAS 544662-11-5C14H12BrN3O3S
![3-Chloro-N-[(E)-(3-methylthiophen-2-yl)methylideneamino]benzamide chemical structure, C13H11ClN2OS, CAS 113874-65-0](/s/DZEJOVYESVFVMB-OVCLIPMQSA-N.svg)
3-Chloro-N-[(E)-(3-methylthiophen-2-yl)methylideneamino]benzamide
CAS 113874-65-0C13H11ClN2OS
![N-[(E)-1-(5-Bromothiophen-2-yl)ethylideneamino]-3-fluorobenzamide chemical structure, C13H10BrFN2OS, CAS 415690-18-5](/s/UBFDPSJXRBXJRY-LZYBPNLTSA-N.svg)
N-[(E)-1-(5-Bromothiophen-2-yl)ethylideneamino]-3-fluorobenzamide
CAS 415690-18-5C13H10BrFN2OS
Benzoic acid (1-thiophen-2-YL-ethylidene)-hydrazide
CAS 113875-20-0C13H12N2OS
![4-Methyl-N-[(E)-thiophen-2-ylmethylideneamino]benzamide chemical structure, C13H12N2OS, CAS 5569-22-2](/s/RLSYPONHVIZWMZ-NTEUORMPSA-N.svg)
4-Methyl-N-[(E)-thiophen-2-ylmethylideneamino]benzamide
CAS 5569-22-2C13H12N2OS
![N-[(E)-1-(5-Chlorothiophen-2-yl)ethylideneamino]-4-hydroxy-3-methoxybenzamide chemical structure, C14H13ClN2O3S, CAS 5531-52-2](/s/REXIXFHBROIHRD-LZYBPNLTSA-N.svg)
N-[(E)-1-(5-Chlorothiophen-2-yl)ethylideneamino]-4-hydroxy-3-methoxybenzamide
CAS 5531-52-2C14H13ClN2O3S
![2-Chloro-N'-[(5-nitro-2-thienyl)methylene]benzohydrazide chemical structure, C12H8ClN3O3S, CAS 294649-23-3](/s/DOSXGYZOVUQOON-VGOFMYFVSA-N.svg)
2-Chloro-N'-[(5-nitro-2-thienyl)methylene]benzohydrazide
CAS 294649-23-3C12H8ClN3O3S
![N-[(E)-(4-Bromothiophen-2-yl)methylideneamino]-2-nitrobenzamide chemical structure, C12H8BrN3O3S, CAS 341999-87-9](/s/OGVMMZDWWDAHQV-MKMNVTDBSA-N.svg)
N-[(E)-(4-Bromothiophen-2-yl)methylideneamino]-2-nitrobenzamide
CAS 341999-87-9C12H8BrN3O3S
![N-[(E)-1-(5-Chlorothiophen-2-yl)ethylideneamino]-4-hydroxybenzamide chemical structure, C13H11ClN2O2S, CAS 393857-63-1](/s/WHLLVNFEOCTUEW-OVCLIPMQSA-N.svg)
N-[(E)-1-(5-Chlorothiophen-2-yl)ethylideneamino]-4-hydroxybenzamide
CAS 393857-63-1C13H11ClN2O2S
4-tert-Butyl-N'-(2-thienylmethylene)benzohydrazide
CAS 113904-68-0C16H18N2OS
![N-[(Z)-1-(5-Bromothiophen-2-yl)propylideneamino]-3,4-dimethoxybenzamide chemical structure, C16H17BrN2O3S, CAS 445006-55-3](/s/JKPHCBVLXHRZMD-WQRHYEAKSA-N.svg)
N-[(Z)-1-(5-Bromothiophen-2-yl)propylideneamino]-3,4-dimethoxybenzamide
CAS 445006-55-3C16H17BrN2O3S
![4-Methoxy-N'-[(E)-(3-methylthiophen-2-yl)methylidene]benzohydrazide chemical structure, C14H14N2O2S, CAS 113874-70-7](/s/VNVNPKGTKHDWRQ-OQLLNIDSSA-N.svg)
4-Methoxy-N'-[(E)-(3-methylthiophen-2-yl)methylidene]benzohydrazide
CAS 113874-70-7C14H14N2O2S
![N-[(Z)-Thiophen-2-ylmethylideneamino]-2,5-bis(2,2,2-trifluoroethoxy)benzamide chemical structure, C16H12F6N2O3S, CAS 477864-06-5](/s/FDQWXQJIONVIIZ-FINSYCMTSA-N.svg)
N-[(Z)-Thiophen-2-ylmethylideneamino]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
CAS 477864-06-5C16H12F6N2O3S
![N'-[(5-Bromo-2-thienyl)methylene]-2-hydroxybenzohydrazide chemical structure, C12H9BrN2O2S, CAS 316129-92-7](/s/PSNHHMRKIZXOLY-VGOFMYFVSA-N.svg)
N'-[(5-Bromo-2-thienyl)methylene]-2-hydroxybenzohydrazide
CAS 316129-92-7C12H9BrN2O2S
![2-Hydroxy-N'-[(3-methyl-2-thienyl)methylene]benzohydrazide chemical structure, C13H12N2O2S, CAS 1400897-79-1](/s/RLMUPDBQEVGEGU-RIYZIHGNSA-N.svg)
2-Hydroxy-N'-[(3-methyl-2-thienyl)methylene]benzohydrazide
CAS 1400897-79-1C13H12N2O2S
- N'-[(5-Bromo-2-thienyl)methylene]-2-chlorobenzohydrazide316149-39-0C12H8BrClN2OS
- 3-Chloro-N-[(E)-(5-nitrothiophen-2-yl)methylideneamino]benzamide304666-81-7C12H8ClN3O3S
- 4-Hydroxy-N-[(E)-(3-methylthiophen-2-yl)methylideneamino]benzamide304478-99-7C13H12N2O2S
- 4-Ethoxy-N-[(E)-(5-nitrothiophen-2-yl)methylideneamino]benzamide314279-81-7C14H13N3O4S
- 3-(Dimethylamino)-N-[(E)-(5-ethylthiophen-2-yl)methylideneamino]benzamide445244-96-2C16H19N3OS
- 3-(Dimethylamino)-N-[(E)-thiophen-2-ylmethylideneamino]benzamide445245-05-6C14H15N3OS
- 2-Hydroxy-N-[(E)-(3-methylthiophen-2-yl)methylideneamino]-3,5-di(propan-2-yl)benzamide445246-50-4C19H24N2O2S
- N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-hydroxy-3,5-di(propan-2-yl)benzamide445246-55-9C18H21ClN2O2S
- 4-Chloro-N-[(E)-(5-ethylthiophen-2-yl)methylideneamino]-2-hydroxybenzamide445246-79-7C14H13ClN2O2S
- 2-Nitro-N'-[(5-nitro-2-thienyl)methylene]benzohydrazide304666-67-9C12H8N4O5S
- 3-Chloro-N'-(2-thienylmethylene)benzohydrazide93418-11-2C12H9ClN2OS
- N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-nitrobenzamide341999-60-8C12H8ClN3O3S
- (E)-N'-((4-Bromothiophen-2-yl)methylene)-2-hydroxybenzohydrazide758701-36-9C12H9BrN2O2S
- 4-Hydroxy-N'-(2-thienylmethylene)benzohydrazide91973-72-7C12H10N2O2S
- 2-Hydroxy-N'-(2-thienylmethylene)benzohydrazide93352-51-3C12H10N2O2S
- 3-Fluoro-N-[(E)-thiophen-2-ylmethylideneamino]benzamide93418-08-7C12H9FN2OS
- MitoBloCK-10394694-98-5C12H8FN3O3S
- Benzene acid, (2-thienylmethylene)hydrazide84889-00-9C12H10N2OS
- 4-Bromo-N-[(E)-(3-methylthiophen-2-yl)methylideneamino]benzamide301318-43-4C13H11BrN2OS
- N'-[1-(5-Bromo-2-thienyl)ethylidene]-3,4-dichlorobenzohydrazide419558-08-0C13H9BrCl2N2OS
- N'-[(1E)-1-(5-Chlorothiophen-2-yl)ethylidene]-2-hydroxybenzohydrazide329024-72-8C13H11ClN2O2S
- 2-Hydroxy-N'-[(5-nitro-2-thienyl)methylene]benzohydrazide316131-73-4C12H9N3O4S
- 3-Bromo-N'-(1-(2-thienyl)ethylidene)benzohydrazide293763-54-9C13H11BrN2OS
- N'-[1-(5-Ethyl-2-thienyl)ethylidene]-2-hydroxy-3,5-diisopropylbenzohydrazide445246-44-6C21H28N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
O=C(CCN1CCCC1)Nc1ccccc120 chemicals
O=C(NN=Cc1ccco1)c1ccccc119 chemicals