Murcko scaffold
Pyrimidine scaffold
19,000 chemicals on CompoundList share this ring system.
- Rings
- 1
- Scaffold atoms
- 6
- Chemicals
- 19,000
- With full pages
- 2,066
Scaffold SMILES
c1cncnc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1,057 to 1,104 of 19,000 chemicals
4-Aminopyrimidine-5-carboxylic acid
CAS 20737-41-1C5H5N3O2
5-Chloro-4-hydrazinylpyrimidine
CAS 122082-97-7C4H5ClN4
2-Amino-4,6-difluoropyrimidine
CAS 675-11-6C4H3F2N3
4-Chloro-6-ethoxy-5-nitropyrimidine
CAS 54851-36-4C6H6ClN3O3
5-Bromopyrimidine-4,6-diamine
CAS 58023-98-6C4H5BrN4
5-Chloro-2-methanesulfonylpyrimidine-4-carboxylic acid
CAS 38275-34-2C6H5ClN2O4S
![1-[(4,6-Dimethylpyrimidin-2-yl)amino]-3-methylthiourea chemical structure, C8H13N5S, CAS 211574-56-0](/s/MRADRRUYJLSJJU-UHFFFAOYSA-N.svg)
1-[(4,6-Dimethylpyrimidin-2-yl)amino]-3-methylthiourea
CAS 211574-56-0C8H13N5S
2-Hydrazino-4-(trifluoromethyl)pyrimidine
CAS 197305-97-8C5H5F3N4
4-Methoxy-N,6-dimethylpyrimidin-2-amine
CAS 66131-76-8C7H11N3O
Pyrimidine, 4-methyl-6-(methylthio)-
CAS 62671-89-0C6H8N2S
![[(6-Methylpyrimidin-4-yl)thio]acetic acid chemical structure, C7H8N2O2S, CAS 88784-34-3](/s/CFSNFUIDTYQLSG-UHFFFAOYSA-N.svg)
[(6-Methylpyrimidin-4-yl)thio]acetic acid
CAS 88784-34-3C7H8N2O2S
1-(4,6-Dimethoxy-5-nitropyrimidin-2-yl)propan-2-one
CAS 69098-63-1C9H11N3O5
Ethyl pyrimidin-2-ylglycinate
CAS 23082-27-1C8H11N3O2
5-Ethynylpyrimidine
CAS 153286-94-3C6H4N2
![N-[4-Chloro-6-(isopropylamino)-5-(methylsulfanyl)-2-pyrimidinyl]-N-methylamine chemical structure, C9H15ClN4S, CAS 55921-78-3](/s/BICSYWBECUXRON-UHFFFAOYSA-N.svg)
N-[4-Chloro-6-(isopropylamino)-5-(methylsulfanyl)-2-pyrimidinyl]-N-methylamine
CAS 55921-78-3C9H15ClN4S
N-(4,6-Dimethylpyrimidin-2-yl)-3-oxobutanamide
CAS 338420-50-1C10H13N3O2
4,5-Dimethoxy-N,N-dimethylpyrimidin-2-amine
CAS 400082-34-0C8H13N3O2
Ethyl 2-((4-chloro-5-methoxypyrimidin-2-yl)thio)acetate
CAS 338423-24-8C9H11ClN2O3S
Methyl 2-((4,5-dimethoxy-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-43-1C9H12N2O4S
4-(Chlorodifluoromethyl)-6-methylpyrimidin-2-amine
CAS 263276-46-6C6H6ClF2N3
(2S)-1,1,1-Trifluoro-3-(2-pyrimidinylsulfanyl)-2-propanol
CAS 477712-81-5C7H7F3N2OS
![2-[(5-Acetyl-4-methyl-2-pyrimidinyl)sulfanyl]acetic acid chemical structure, C9H10N2O3S, CAS 866017-87-0](/s/FERRUCSHSCFFPP-UHFFFAOYSA-N.svg)
2-[(5-Acetyl-4-methyl-2-pyrimidinyl)sulfanyl]acetic acid
CAS 866017-87-0C9H10N2O3S
Hydrazinopyrimidine-5-carbonitrile
CAS 38373-51-2C5H5N5
4,5-Dimethoxy-2-(methylsulfanyl)pyrimidine
CAS 338954-60-2C7H10N2O2S
- Ethyl 2-{[2-(dimethylamino)-5-methoxy-4-pyrimidinyl]sulfanyl}acetate400084-01-7C11H17N3O3S
- Ethyl 2-[(4-{[(dimethylamino)carbonyl]oxy}-5-methoxy-2-pyrimidinyl)sulfanyl]acetate400084-02-8C12H17N3O5S
- N-Isopropyl-4,5-dimethoxy-2-pyrimidinamine400084-03-9C9H15N3O2
- 2-(5-Iodo-2,6-dimethylpyrimidin-4-yl)oxyacetamide677749-37-0C8H10IN3O2
- Ethyl 2-[(5-iodo-2,6-dimethyl-4-pyrimidinyl)oxy]acetate677749-39-2C10H13IN2O3
- Acetic acid, ((6-(2-methoxyethoxy)-4-pyrimidinyl)amino)oxo-, ethyl ester75274-13-4C11H15N3O5
- Acetic acid, ((6-methoxy-4-pyrimidinyl)amino)oxo-, ethyl ester75274-14-5C9H11N3O4
- Acetic acid, ((6-methoxy-2-methyl-4-pyrimidinyl)amino)oxo-, ethyl ester75274-15-6C10H13N3O4
- Acetic acid, ((6-(2-methoxyethoxy)-2-methyl-4-pyrimidinyl)amino)oxo-, ethyl ester75274-17-8C12H17N3O5
- Acetic acid, ((2-methyl-6-(methylthio)-4-pyrimidinyl)amino)oxo-, ethyl ester75274-19-0C10H13N3O3S
- Ethanedioic acid, 2-((6-((ethoxyoxoacetyl)amino)-2-methyl-4-pyrimidinyl)thio)ethyl ethyl ester75274-20-3C15H19N3O7S
- Acetic acid, ((6-chloro-4-pyrimidinyl)amino)oxo-, ethyl ester75274-21-4C8H8ClN3O3
- Acetic acid, oxo(4-pyrimidinylamino)-, ethyl ester75274-22-5C8H9N3O3
- Acetic acid, ((2,6-dimethoxy-4-pyrimidinyl)amino)oxo-, ethyl ester75274-23-6C10H13N3O5
- Ethanedioic acid, 2-((6-((ethoxyoxoacetyl)amino)-4-pyrimidinyl)thio)ethyl ethyl ester75274-24-7C14H17N3O7S
- Propanoic acid, 3-((6-((ethoxyoxoacetyl)amino)-4-pyrimidinyl)thio)-, ethyl ester75274-25-8C13H17N3O5S
- Acetic acid, ((6-((2-methoxyethyl)thio)-2-methyl-4-pyrimidinyl)amino)oxo-, ethyl ester75274-26-9C12H17N3O4S
- Acetic acid, ((6-((2-methoxyethyl)thio)-4-pyrimidinyl)amino)oxo-, ethyl ester75274-27-0C11H15N3O4S
- Acetic acid, ((6-(2-(2-methoxyethoxy)ethoxy)-4-pyrimidinyl)amino)oxo-, ethyl ester75274-28-1C13H19N3O6
- Acetic acid, ((6-((2-(2-methoxyethoxy)ethyl)thio)-4-pyrimidinyl)amino)oxo-, ethyl ester75274-29-2C13H19N3O5S
- Urea, N-(2,6-dimethyl-4-pyrimidinyl)-N'-ethyl-79513-80-7C9H14N4O
- Urea, N-(2,6-dimethyl-4-pyrimidinyl)-N'-(1-methylethyl)-79513-81-8C10H16N4O
- Pyrimidine, 4-(dimethylamino)-6-methyl-99356-90-8C7H11N3
- Tetramethyl (5-nitropyrimidine-2,4-diyl)bis(phosphonate)81216-16-2C8H13N3O8P2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cccc[nH]1](/scaffold/UBQKCCHYAOITMY-UHFFFAOYSA-N/structure.svg)
![Scaffold O=c1cc[nH]c(=O)[nH]1](/scaffold/ISAKRJDGNUQOIC-UHFFFAOYSA-N/structure.svg)