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Murcko scaffold

Ring system with 3 rings and 21 atoms

306 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
306
With full pages
3
Scaffold SMILES

O=C(CSc1nc2ccsc2c(=O)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc2ccsc2c(=O)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 306 chemicals

Methyl 2-[[2-(3-butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanylacetyl]amino]benzoate chemical structure, C20H21N3O4S2, CAS 440328-99-4
Methyl 2-[[2-(3-butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanylacetyl]amino]benzoate
CAS 440328-99-4C20H21N3O4S2
N-(4-Ethoxyphenyl)-2-[3-(3-methylbutyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]sulfanylacetamide chemical structure, C21H25N3O3S2, CAS 440329-76-0
N-(4-Ethoxyphenyl)-2-[3-(3-methylbutyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]sulfanylacetamide
CAS 440329-76-0C21H25N3O3S2
2-[3-(3-Methylbutyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C20H20F3N3O2S2, CAS 440329-84-0
2-[3-(3-Methylbutyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 440329-84-0C20H20F3N3O2S2
N-(4-Ethoxyphenyl)-2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C18H19N3O3S2, CAS 896793-56-9
N-(4-Ethoxyphenyl)-2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
CAS 896793-56-9C18H19N3O3S2
Methyl 2-[2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamido]benzoate chemical structure, C18H17N3O4S2, CAS 896793-58-1
Methyl 2-[2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamido]benzoate
CAS 896793-58-1C18H17N3O4S2
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-(4-ethoxyphenyl)acetamide chemical structure, C20H23N3O3S2, CAS 440328-59-6
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-(4-ethoxyphenyl)acetamide
CAS 440328-59-6C20H23N3O3S2
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-(3-methoxyphenyl)acetamide chemical structure, C19H21N3O3S2, CAS 440328-65-4
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-(3-methoxyphenyl)acetamide
CAS 440328-65-4C19H21N3O3S2
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C19H18F3N3O2S2, CAS 440328-67-6
2-(3-Butyl-4-oxothieno[3,2-d]pyrimidin-2-yl)sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 440328-67-6C19H18F3N3O2S2
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(4-methoxyphenyl)acetamide chemical structure, C17H17N3O3S2, CAS 688347-35-5
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(4-methoxyphenyl)acetamide
CAS 688347-35-5C17H17N3O3S2
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(3-ethylphenyl)acetamide chemical structure, C18H19N3O2S2, CAS 892285-32-4
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(3-ethylphenyl)acetamide
CAS 892285-32-4C18H19N3O2S2
N-(2-Methoxyphenyl)-2-({3-methyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C16H15N3O3S2, CAS 923900-19-0
N-(2-Methoxyphenyl)-2-({3-methyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
CAS 923900-19-0C16H15N3O3S2
N-(3,5-Dimethoxyphenyl)-2-({3-methyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C17H17N3O4S2, CAS 924232-94-0
N-(3,5-Dimethoxyphenyl)-2-({3-methyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
CAS 924232-94-0C17H17N3O4S2
N-(3-Chloro-4-methoxyphenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide chemical structure, C19H20ClN3O3S2, CAS 923226-64-6
N-(3-Chloro-4-methoxyphenyl)-2-{[3-(2-methylpropyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide
CAS 923226-64-6C19H20ClN3O3S2
Ethyl 2-(2-((3-isobutyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamido)benzoate chemical structure, C21H23N3O4S2, CAS 923179-49-1
Ethyl 2-(2-((3-isobutyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamido)benzoate
CAS 923179-49-1C21H23N3O4S2
N-(2,4-Dimethoxyphenyl)-2-((3-(2-hydroxyethyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C18H19N3O5S2, CAS 923249-87-0
N-(2,4-Dimethoxyphenyl)-2-((3-(2-hydroxyethyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 923249-87-0C18H19N3O5S2
N-(3,5-Difluorophenyl)-2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide chemical structure, C16H13F2N3O2S2, CAS 1030188-52-3
N-(3,5-Difluorophenyl)-2-({3-ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
CAS 1030188-52-3C16H13F2N3O2S2
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(3,4,5-trimethoxyphenyl)acetamide chemical structure, C19H21N3O5S2, CAS 1031038-49-9
2-({3-Ethyl-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)-N-(3,4,5-trimethoxyphenyl)acetamide
CAS 1031038-49-9C19H21N3O5S2
N-(3-Methoxyphenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C16H15N3O3S2, CAS 1252918-43-6
N-(3-Methoxyphenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
CAS 1252918-43-6C16H15N3O3S2
2-[(3-Methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(3-methylphenyl)acetamide chemical structure, C16H15N3O2S2, CAS 1252912-58-5
2-[(3-Methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(3-methylphenyl)acetamide
CAS 1252912-58-5C16H15N3O2S2
N-(2,5-Dimethoxyphenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C17H17N3O4S2, CAS 1252815-77-2
N-(2,5-Dimethoxyphenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 1252815-77-2C17H17N3O4S2
N-(4-Methoxyphenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C16H15N3O3S2, CAS 1252917-24-0
N-(4-Methoxyphenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 1252917-24-0C16H15N3O3S2
N-(4-Bromo-2-fluorophenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C15H11BrFN3O2S2, CAS 1252847-52-1
N-(4-Bromo-2-fluorophenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
CAS 1252847-52-1C15H11BrFN3O2S2
N-(2-Ethoxyphenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide chemical structure, C17H17N3O3S2, CAS 1326264-27-0
N-(2-Ethoxyphenyl)-2-[(3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
CAS 1326264-27-0C17H17N3O3S2
N-(3-Chlorophenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide chemical structure, C15H12ClN3O2S2, CAS 1252931-25-1
N-(3-Chlorophenyl)-2-((3-methyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide
CAS 1252931-25-1C15H12ClN3O2S2