Murcko scaffold
Ring system with 4 rings and 23 atoms
17 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 23
- Chemicals
- 17
- With full pages
- 1
Scaffold SMILES
O=c1c(=Cc2ccccc2)sc2n1C=CC(c1ccccc1)C=2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 17 of 17 chemicals
![Ethyl 5-amino-6-cyano-7-(4-ethoxyphenyl)-2-[(4-ethoxyphenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-8-carboxylate chemical structure, C28H27N3O5S, CAS 370841-91-1](/s/VFJACBJTPDSEBO-UHFFFAOYSA-N.svg)
Ethyl 5-amino-6-cyano-7-(4-ethoxyphenyl)-2-[(4-ethoxyphenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-8-carboxylate
CAS 370841-91-1C28H27N3O5S
![(2Z)-5-Amino-3-oxo-7-[2-(trifluoromethyl)phenyl]-2-[[2-(trifluoromethyl)phenyl]methylidene]-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile chemical structure, C24H12F6N4OS, CAS 339156-33-1](/s/ZQOKNGGFAACEHW-NVMNQCDNSA-N.svg)
(2Z)-5-Amino-3-oxo-7-[2-(trifluoromethyl)phenyl]-2-[[2-(trifluoromethyl)phenyl]methylidene]-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
CAS 339156-33-1C24H12F6N4OS
![(2Z)-5-Amino-7-(3-methoxyphenyl)-2-[(3-methoxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile chemical structure, C24H18N4O3S, CAS 298217-06-8](/s/FSVDYOCGEXYJPN-JMIUGGIZSA-N.svg)
(2Z)-5-Amino-7-(3-methoxyphenyl)-2-[(3-methoxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
CAS 298217-06-8C24H18N4O3S
![(2Z)-5-Amino-7-(4-ethylphenyl)-2-[(4-ethylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile chemical structure, C26H22N4OS, CAS 298217-04-6](/s/PJNYGSUCNUGLHR-XKZIYDEJSA-N.svg)
(2Z)-5-Amino-7-(4-ethylphenyl)-2-[(4-ethylphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
CAS 298217-04-6C26H22N4OS
![(2Z)-5-Amino-7-(3,4-dimethoxyphenyl)-2-[(3,4-dimethoxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile chemical structure, C26H22N4O5S, CAS 154365-91-0](/s/PSFBKMLCBXEIPM-YVNNLAQVSA-N.svg)
(2Z)-5-Amino-7-(3,4-dimethoxyphenyl)-2-[(3,4-dimethoxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
CAS 154365-91-0C26H22N4O5S
![Ethyl (2Z)-5-amino-6-cyano-7-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxylate chemical structure, C24H19N3O5S, CAS 5678-53-5](/s/PRNGWPHJMXIJDB-WQRHYEAKSA-N.svg)
Ethyl (2Z)-5-amino-6-cyano-7-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxylate
CAS 5678-53-5C24H19N3O5S
![5-Amino-2-(4-methoxy-benzylidene)-7-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile chemical structure, C24H18N4O3S, CAS 75052-59-4](/s/YQJQASJBTLOOCV-RGVLZGJSSA-N.svg)
5-Amino-2-(4-methoxy-benzylidene)-7-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile
CAS 75052-59-4C24H18N4O3S
![Methyl 5-amino-8-cyano-2-(4-ethoxybenzylidene)-7-(4-ethoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6-carboxylate chemical structure, C27H25N3O5S, CAS 353461-58-2](/s/SVXGVTHXOZYKKR-STZFKDTASA-N.svg)
Methyl 5-amino-8-cyano-2-(4-ethoxybenzylidene)-7-(4-ethoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6-carboxylate
CAS 353461-58-2C27H25N3O5S
![Ethyl (2Z)-5-amino-7-(2-chlorophenyl)-2-[(2-chlorophenyl)methylidene]-6-cyano-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxylate chemical structure, C24H17Cl2N3O3S, CAS 330158-77-5](/s/WSEUJRKRDOEWSD-WQRHYEAKSA-N.svg)
Ethyl (2Z)-5-amino-7-(2-chlorophenyl)-2-[(2-chlorophenyl)methylidene]-6-cyano-3-oxo-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxylate
CAS 330158-77-5C24H17Cl2N3O3S
![6-Ethyl 8-methyl 5-amino-2-(4-chlorobenzylidene)-7-(4-chlorophenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C25H20Cl2N2O5S, CAS 353461-70-8](/s/WGGVEIMYEKAPFE-ATVHPVEESA-N.svg)
6-Ethyl 8-methyl 5-amino-2-(4-chlorobenzylidene)-7-(4-chlorophenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 353461-70-8C25H20Cl2N2O5S
![6-Ethyl 8-isopropyl 5-amino-2-(4-methoxybenzylidene)-7-(4-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C29H30N2O7S, CAS 352663-23-1](/s/QSHOVOSIKPNDHC-QNGOZBTKSA-N.svg)
6-Ethyl 8-isopropyl 5-amino-2-(4-methoxybenzylidene)-7-(4-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 352663-23-1C29H30N2O7S
![6-Ethyl 8-methyl 5-amino-2-(3-bromobenzylidene)-7-(3-bromophenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C25H20Br2N2O5S, CAS 353461-72-0](/s/QDLRWCFGCWRDPZ-BOPFTXTBSA-N.svg)
6-Ethyl 8-methyl 5-amino-2-(3-bromobenzylidene)-7-(3-bromophenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 353461-72-0C25H20Br2N2O5S
![6-Ethyl 8-methyl 5-amino-2-(4-methoxybenzylidene)-7-(4-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C27H26N2O7S, CAS 353461-60-6](/s/WQQAXTIMFPSTHD-RGEXLXHISA-N.svg)
6-Ethyl 8-methyl 5-amino-2-(4-methoxybenzylidene)-7-(4-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 353461-60-6C27H26N2O7S
![6-Ethyl 8-methyl 5-amino-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C31H34N2O5S, CAS 328071-58-5](/s/UOCGVQLJQAZWGC-KQWNVCNZSA-N.svg)
6-Ethyl 8-methyl 5-amino-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 328071-58-5C31H34N2O5S
![Dimethyl 5-amino-2-(4-hydroxy-3-methoxybenzylidene)-7-(4-hydroxy-3-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate chemical structure, C26H24N2O9S, CAS 353461-93-5](/s/SUMHTCVYSHXTLM-ZDLGFXPLSA-N.svg)
Dimethyl 5-amino-2-(4-hydroxy-3-methoxybenzylidene)-7-(4-hydroxy-3-methoxyphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarboxylate
CAS 353461-93-5C26H24N2O9S
![5-Amino-6-cyano-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxamide chemical structure, C28H28N4O2S, CAS 352663-19-5](/s/DOKGMYXRWUTIJR-XKZIYDEJSA-N.svg)
5-Amino-6-cyano-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-8-carboxamide
CAS 352663-19-5C28H28N4O2S
![Methyl 5-amino-8-cyano-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6-carboxylate chemical structure, C29H29N3O3S, CAS 353461-59-3](/s/VKZJERGLTYMWTL-UCQKPKSFSA-N.svg)
Methyl 5-amino-8-cyano-2-(4-isopropylbenzylidene)-7-(4-isopropylphenyl)-3-oxo-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6-carboxylate
CAS 353461-59-3C29H29N3O3S
Related scaffolds
Same ring framework with different atoms or bond orders
O=c1nc2sc(=Cc3ccccc3)c(=O)n2nc1-c1ccccc117 chemicals
O=C(c1ccccc1)c1cc2ccc(-c3ccccc3)nc2s19 chemicals
O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCOCC12 chemicals
O=c1c(=Cc2ccccn2)sc2n1CN(c1ccccc1)CN=22 chemicals
O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCCCC11 chemical
O=c1c(=Cc2ccccc2)sc2n1CN(c1ccccc1)CN=21 chemical
O=C(c1nc2nc(-c3ccccc3)ccn2n1)N1CCCCC11 chemical
O=c1c(=Cc2cccnc2)sc2n1CN(c1ccccc1)CN=21 chemical![Scaffold O=C1CC(c2ccccc2)Cc2[nH]c(C(=O)N3CCOCC3)cc21](/scaffold/VEYQFWCCTLGLGB-UHFFFAOYSA-N/structure.svg)
O=C1CC(c2ccccc2)Cc2[nH]c(C(=O)N3CCOCC3)cc211 chemical
O=C(c1cc2n(n1)CCC(c1ccccc1)N2)N1CCOCC11 chemical