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Murcko scaffold

Ring system with 4 rings and 23 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
11
With full pages
2
Scaffold SMILES

O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

(7-Methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)-morpholin-4-ylmethanone chemical structure, C18H18N4O2, CAS 313246-51-4
(7-Methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)-morpholin-4-ylmethanone
CAS 313246-51-4C18H18N4O2
[5-(3,4-Dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone chemical structure, C20H19F3N4O4, CAS 333761-17-4
[5-(3,4-Dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone
CAS 333761-17-4C20H19F3N4O4
2-(4-Morpholinylcarbonyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H15F3N4O2, CAS 304686-67-7
2-(4-Morpholinylcarbonyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 304686-67-7C18H15F3N4O2
[5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone chemical structure, C18H14F4N4O2, CAS 5843-01-6
[5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone
CAS 5843-01-6C18H14F4N4O2
5-(4-Bromophenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H14BrF3N4O2, CAS 313248-89-4
5-(4-Bromophenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 313248-89-4C18H14BrF3N4O2
5-(4-Bromophenyl)-3-chloro-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H13BrClF3N4O2, CAS 333764-34-4
5-(4-Bromophenyl)-3-chloro-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 333764-34-4C18H13BrClF3N4O2
[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone chemical structure, C19H16ClF3N4O3, CAS 313396-07-5
[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-morpholin-4-ylmethanone
CAS 313396-07-5C19H16ClF3N4O3
3-Chloro-5-(4-chlorophenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H13Cl2F3N4O2, CAS 313396-20-2
3-Chloro-5-(4-chlorophenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 313396-20-2C18H13Cl2F3N4O2
5-(4-Methylphenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H17F3N4O2, CAS 348151-18-8
5-(4-Methylphenyl)-2-(4-morpholinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 348151-18-8C19H17F3N4O2
[3-Bromo-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone chemical structure, C19H16BrF3N4O3, CAS 299406-52-3
[3-Bromo-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](morpholin-4-yl)methanone
CAS 299406-52-3C19H16BrF3N4O3
Morpholin-4-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone chemical structure, C18H14F3N5O4, CAS 333765-17-6
Morpholin-4-yl-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
CAS 333765-17-6C18H14F3N5O4