Murcko scaffold
Ring system with 4 rings and 23 atoms
40 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 23
- Chemicals
- 40
- With full pages
- 1
Scaffold SMILES
O=c1c(=Cc2ccccc2)sc2n1CN(c1ccccc1)CN=2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 40 of 40 chemicals
![(7Z)-3-(3-Nitrophenyl)-7-[(3,4,5-trimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H20N4O6S, CAS 690688-68-7](/s/GXRCRXIZIDMYLK-NVMNQCDNSA-N.svg)
(7Z)-3-(3-Nitrophenyl)-7-[(3,4,5-trimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690688-68-7C21H20N4O6S
![(7Z)-3-(4-Bromophenyl)-7-[(3,4-dimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H18BrN3O3S, CAS 690694-90-7](/s/NQBYBCSFSPNLCV-ZDLGFXPLSA-N.svg)
(7Z)-3-(4-Bromophenyl)-7-[(3,4-dimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690694-90-7C20H18BrN3O3S
![(7Z)-7-[(3-Chlorophenyl)methylidene]-3-(4-fluorophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H13ClFN3OS, CAS 690695-91-1](/s/GKMBDGRJWYLJLF-SXGWCWSVSA-N.svg)
(7Z)-7-[(3-Chlorophenyl)methylidene]-3-(4-fluorophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690695-91-1C18H13ClFN3OS
![(7Z)-3-(4-Chlorophenyl)-7-[(4-methoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C19H16ClN3O2S, CAS 690687-48-0](/s/CEPZIRGVYPRXDU-YVLHZVERSA-N.svg)
(7Z)-3-(4-Chlorophenyl)-7-[(4-methoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690687-48-0C19H16ClN3O2S
![(7Z)-7-Benzylidene-3-(4-chlorophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H14ClN3OS, CAS 690694-10-1](/s/USGWQXMAFLESPV-YBEGLDIGSA-N.svg)
(7Z)-7-Benzylidene-3-(4-chlorophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690694-10-1C18H14ClN3OS
![(7Z)-3-(4-Fluorophenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H13FN4O3S, CAS 690696-90-3](/s/XRQQYNFOLUWLDO-SXGWCWSVSA-N.svg)
(7Z)-3-(4-Fluorophenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690696-90-3C18H13FN4O3S
![(7Z)-7-[(3-Chlorophenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H13ClN4O3S, CAS 690699-56-0](/s/NPXYPCMQYMHOQI-PXNMLYILSA-N.svg)
(7Z)-7-[(3-Chlorophenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 690699-56-0C18H13ClN4O3S
![(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H18F3N3O3S, CAS 6583-65-9](/s/UQCZYQALKASKRW-NVMNQCDNSA-N.svg)
(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 6583-65-9C21H18F3N3O3S
![(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H18N4O4S, CAS 381683-13-2](/s/XXPHGJNZOBSZQL-ZDLGFXPLSA-N.svg)
(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381683-13-2C20H18N4O4S
![(7Z)-7-[(3-Nitrophenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C19H13F3N4O3S, CAS 380588-67-0](/s/RXRHBTCCSHZCMS-PXNMLYILSA-N.svg)
(7Z)-7-[(3-Nitrophenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380588-67-0C19H13F3N4O3S
![(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H18N4O5S, CAS 378766-74-6](/s/QQLBACMFMXLWTH-NVMNQCDNSA-N.svg)
(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-(3-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 378766-74-6C20H18N4O5S
![(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H21N3O2S, CAS 378217-65-3](/s/KTUAVOMCJGKOKB-UNOMPAQXSA-N.svg)
(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 378217-65-3C21H21N3O2S
![(7Z)-3-(3-Fluorophenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H13FN4O3S, CAS 381714-26-7](/s/LGIJYKFWIVZTIV-PXNMLYILSA-N.svg)
(7Z)-3-(3-Fluorophenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381714-26-7C18H13FN4O3S
![(7Z)-3-(3-Acetylphenyl)-7-[(4-ethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C22H21N3O3S, CAS 381177-57-7](/s/YECBBKJOVZMNJU-JAIQZWGSSA-N.svg)
(7Z)-3-(3-Acetylphenyl)-7-[(4-ethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381177-57-7C22H21N3O3S
![(7Z)-3-(4-Acetylphenyl)-7-[(3,4-dimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C22H21N3O4S, CAS 352329-75-0](/s/WPPPQYBBVDXGRR-JAIQZWGSSA-N.svg)
(7Z)-3-(4-Acetylphenyl)-7-[(3,4-dimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 352329-75-0C22H21N3O4S
![(7Z)-3-(4-Acetylphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H16N4O4S, CAS 380595-21-1](/s/VQBQNVFOFVMDJE-ZDLGFXPLSA-N.svg)
(7Z)-3-(4-Acetylphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380595-21-1C20H16N4O4S
![(7Z)-3-(4-Ethoxyphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H18N4O4S, CAS 380583-61-9](/s/QIIJKDHMTGSFMF-WQRHYEAKSA-N.svg)
(7Z)-3-(4-Ethoxyphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380583-61-9C20H18N4O4S
![(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H18F3N3O2S, CAS 6608-56-6](/s/NMFYWAOXJVQVGT-ZDLGFXPLSA-N.svg)
(7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-[3-(trifluoromethyl)phenyl]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 6608-56-6C21H18F3N3O2S
![(Z)-Ethyl 4-(7-(3,4-dimethoxybenzylidene)-6-oxo-6,7-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-3(4H)-yl)benzoate chemical structure, C23H23N3O5S, CAS 378777-54-9](/s/JRKCKWCCVFCSRY-NDENLUEZSA-N.svg)
(Z)-Ethyl 4-(7-(3,4-dimethoxybenzylidene)-6-oxo-6,7-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-3(4H)-yl)benzoate
CAS 378777-54-9C23H23N3O5S
![(7Z)-7-[(4-Methoxyphenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C20H19N3O2S, CAS 381174-55-6](/s/MLQWWCNITSALNI-WQRHYEAKSA-N.svg)
(7Z)-7-[(4-Methoxyphenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381174-55-6C20H19N3O2S
![(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-(4-methoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H21N3O4S, CAS 381167-87-9](/s/MYTGITUMIZSHQO-ODLFYWEKSA-N.svg)
(7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-(4-methoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381167-87-9C21H21N3O4S
![(7Z)-7-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C21H20N4O5S, CAS 380574-61-8](/s/MDHNLGLIEPTWRY-OCKHKDLRSA-N.svg)
(7Z)-7-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]-3-(4-methylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 380574-61-8C21H20N4O5S
![(7Z)-7-[(3-Nitrophenyl)methylidene]-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one chemical structure, C18H14N4O3S, CAS 381692-75-7](/s/CVNWDOFHSNFXOM-YBEGLDIGSA-N.svg)
(7Z)-7-[(3-Nitrophenyl)methylidene]-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one
CAS 381692-75-7C18H14N4O3S
![Ethyl 4-[(7Z)-6-oxo-7-[(3,4,5-trimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate chemical structure, C24H25N3O6S, CAS 690696-56-1](/s/PYJKXOWVNFZPSW-NDENLUEZSA-N.svg)
Ethyl 4-[(7Z)-6-oxo-7-[(3,4,5-trimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate
CAS 690696-56-1C24H25N3O6S
- Ethyl 4-[(7Z)-7-benzylidene-6-oxo-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate690694-99-6C21H19N3O3S
- (7Z)-3-(3-Acetylphenyl)-7-benzylidene-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one690697-56-4C20H17N3O2S
- (7Z)-3-(4-Fluorophenyl)-7-[(4-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one489400-10-4C18H13FN4O3S
- (7Z)-3-(3,4-Dimethylphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one690685-11-1C20H18N4O3S
- (7Z)-3-(4-Acetylphenyl)-7-[(3-chlorophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one690687-12-8C20H16ClN3O2S
- (7Z)-7-Benzylidene-3-phenyl-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one1334176-95-2C18H15N3OS
- (7Z)-7-Benzylidene-3-(4-ethylphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one840472-61-9C20H19N3OS
- (7Z)-3-(3-Acetylphenyl)-7-[(3,4-dimethoxyphenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one381184-47-0C22H21N3O4S
- (7Z)-3-(3-Acetylphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one381695-92-7C20H16N4O4S
- Ethyl 4-[(7Z)-7-[(4-nitrophenyl)methylidene]-6-oxo-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-3-yl]benzoate488100-21-6C21H18N4O5S
- (7Z)-3-(3-Acetylphenyl)-7-[(4-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one500270-99-5C20H16N4O4S
- (7Z)-7-Benzylidene-3-(3,4,5-trimethoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one488118-76-9C21H21N3O4S
- (7Z)-7-[(3-Nitrophenyl)methylidene]-3-(3,4,5-trimethoxyphenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one500276-47-1C21H20N4O6S
- 3-(3,4-Dimethoxyphenyl)-7-[(3-nitrophenyl)methylidene]-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one4659-59-0C20H18N4O5S
- (7Z)-7-[(3,4-Dimethoxyphenyl)methylidene]-3-(4-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one381714-49-4C20H18N4O5S
- (7Z)-7-[(4-Ethoxyphenyl)methylidene]-3-(4-nitrophenyl)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one381172-15-2C20H18N4O4S
Related scaffolds
Same ring framework with different atoms or bond orders
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