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Murcko scaffold

Ring system with 4 rings and 23 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
16
With full pages
1
Scaffold SMILES

O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2nc(-c3ccccc3)ccn2n1)N1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

(7-Methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)-piperidin-1-ylmethanone chemical structure, C19H20N4O, CAS 312634-72-3
(7-Methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)-piperidin-1-ylmethanone
CAS 312634-72-3C19H20N4O
[5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](piperidin-1-yl)methanone chemical structure, C19H16F4N4O, CAS 313247-77-7
[5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl](piperidin-1-yl)methanone
CAS 313247-77-7C19H16F4N4O
3-Bromo-5-phenyl-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H16BrF3N4O, CAS 300717-64-0
3-Bromo-5-phenyl-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 300717-64-0C19H16BrF3N4O
[3-Chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone chemical structure, C19H16ClF3N4O, CAS 304687-22-7
[3-Chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone
CAS 304687-22-7C19H16ClF3N4O
4-[3-Bromo-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5-yl]phenyl methyl ether chemical structure, C20H18BrF3N4O2, CAS 313245-67-9
4-[3-Bromo-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5-yl]phenyl methyl ether
CAS 313245-67-9C20H18BrF3N4O2
[3-Chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperidin-1-yl)methanone chemical structure, C20H18ClF3N4O, CAS 312634-17-6
[3-Chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperidin-1-yl)methanone
CAS 312634-17-6C20H18ClF3N4O
5-(4-Bromophenyl)-3-chloro-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C19H15BrClF3N4O, CAS 333764-33-3
5-(4-Bromophenyl)-3-chloro-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 333764-33-3C19H15BrClF3N4O
[5-(4-Nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone chemical structure, C19H16F3N5O3, CAS 333765-16-5
[5-(4-Nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone
CAS 333765-16-5C19H16F3N5O3
[3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone chemical structure, C21H20ClF3N4O3, CAS 330950-36-2
[3-Chloro-5-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-piperidin-1-ylmethanone
CAS 330950-36-2C21H20ClF3N4O3
5-(4-Methylphenyl)-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H19F3N4O, CAS 348151-19-9
5-(4-Methylphenyl)-2-(1-piperidinylcarbonyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 348151-19-9C20H19F3N4O
[5-(3,4-Dimethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperidin-1-yl)methanone chemical structure, C22H23F3N4O, CAS 438221-78-4
[5-(3,4-Dimethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(4-methylpiperidin-1-yl)methanone
CAS 438221-78-4C22H23F3N4O
(2,6-Dimethylpiperidin-1-yl)(7-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)methanone chemical structure, C21H24N4O, CAS 381702-07-4
(2,6-Dimethylpiperidin-1-yl)(7-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-2-yl)methanone
CAS 381702-07-4C21H24N4O
[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone chemical structure, C21H20ClF3N4O2, CAS 5821-84-1
[3-Chloro-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(2-methylpiperidin-1-yl)methanone
CAS 5821-84-1C21H20ClF3N4O2
(2,6-Dimethylpiperidin-1-yl)-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone chemical structure, C22H23F3N4O, CAS 348151-41-7
(2,6-Dimethylpiperidin-1-yl)-[5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
CAS 348151-41-7C22H23F3N4O
(2-Methylpiperidin-1-yl)-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone chemical structure, C20H18F3N5O3, CAS 333765-39-2
(2-Methylpiperidin-1-yl)-[5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]methanone
CAS 333765-39-2C20H18F3N5O3
[5-(3,4-Dimethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(3,5-dimethylpiperidin-1-yl)methanone chemical structure, C23H25F3N4O, CAS 438218-51-0
[5-(3,4-Dimethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-2-yl]-(3,5-dimethylpiperidin-1-yl)methanone
CAS 438218-51-0C23H25F3N4O