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Murcko scaffold

Ring system with 4 rings and 21 atoms

25 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
25
With full pages
7
Scaffold SMILES

c1ccc(-c2cnn3c(-c4ccccc4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(-c4ccccc4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

3-(4-Chlorophenyl)-2,5-dimethyl-7-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16ClN3, CAS 419547-42-5
3-(4-Chlorophenyl)-2,5-dimethyl-7-phenylpyrazolo[1,5-a]pyrimidine
CAS 419547-42-5C20H16ClN3
2,5-Dimethyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H17N3, CAS 428832-84-2
2,5-Dimethyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine
CAS 428832-84-2C20H17N3
2-Methyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H15N3, CAS 130159-70-5
2-Methyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine
CAS 130159-70-5C19H15N3
7-(4-Chlorophenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H14ClN3, CAS 444790-86-7
7-(4-Chlorophenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 444790-86-7C19H14ClN3
2-Methyl-7-(4-methylphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H17N3, CAS 712274-42-5
2-Methyl-7-(4-methylphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 712274-42-5C20H17N3
Ethyl 2-methyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C22H19N3O2, CAS 664360-36-5
Ethyl 2-methyl-3,7-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxylate
CAS 664360-36-5C22H19N3O2
3-(3-Bromophenyl)-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H14BrN3, CAS 432532-76-8
3-(3-Bromophenyl)-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidine
CAS 432532-76-8C19H14BrN3
3-(4-Fluorophenyl)-7-(3-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16FN3O, CAS 878994-38-8
3-(4-Fluorophenyl)-7-(3-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 878994-38-8C20H16FN3O
7-(3,4-Dimethoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H19N3O2, CAS 886154-55-8
7-(3,4-Dimethoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 886154-55-8C21H19N3O2
3-(4-Chlorophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16ClN3O, CAS 886154-76-3
3-(4-Chlorophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 886154-76-3C20H16ClN3O
7-(2-Methoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H17N3O, CAS 886154-48-9
7-(2-Methoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 886154-48-9C20H17N3O
3-(4-Fluorophenyl)-2-methyl-7-(2-methylphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C20H16FN3, CAS 878994-40-2
3-(4-Fluorophenyl)-2-methyl-7-(2-methylphenyl)pyrazolo[1,5-a]pyrimidine
CAS 878994-40-2C20H16FN3
7-(3-Methoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H17N3O, CAS 878994-30-0
7-(3-Methoxyphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 878994-30-0C20H17N3O
2-Ethyl-7-(2-methoxyphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H19N3O, CAS 895361-70-3
2-Ethyl-7-(2-methoxyphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 895361-70-3C21H19N3O
7-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C21H18FN3O2, CAS 895361-54-3
7-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 895361-54-3C21H18FN3O2
3-(4-Fluorophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16FN3O, CAS 886155-17-5
3-(4-Fluorophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 886155-17-5C20H16FN3O
3-(4-Bromophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16BrN3O, CAS 895361-61-2
3-(4-Bromophenyl)-7-(2-methoxyphenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 895361-61-2C20H16BrN3O
2-Ethyl-3-(4-fluorophenyl)-7-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H18FN3O, CAS 895361-73-6
2-Ethyl-3-(4-fluorophenyl)-7-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS 895361-73-6C21H18FN3O
2-(Methoxymethyl)-3-(4-methoxyphenyl)-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C22H21N3O2, CAS 948674-19-9
2-(Methoxymethyl)-3-(4-methoxyphenyl)-5-methyl-7-phenylpyrazolo[1,5-a]pyrimidine
CAS 948674-19-9C22H21N3O2
3-(4-Chlorophenyl)-2-(methoxymethyl)-7-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H16ClN3O, CAS 948817-39-8
3-(4-Chlorophenyl)-2-(methoxymethyl)-7-phenylpyrazolo[1,5-a]pyrimidine
CAS 948817-39-8C20H16ClN3O
3-(3-Phenylpyrazolo[1,5-a]pyrimidin-7-yl)aniline chemical structure, C18H14N4, CAS 931998-17-3
3-(3-Phenylpyrazolo[1,5-a]pyrimidin-7-yl)aniline
CAS 931998-17-3C18H14N4
3-(2-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)aniline chemical structure, C19H16N4, CAS 932240-90-9
3-(2-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)aniline
CAS 932240-90-9C19H16N4
1-[2-(Methoxymethyl)-3,7-diphenylpyrazolo[1,5-a]pyrimidin-6-yl]ethanone chemical structure, C22H19N3O2, CAS 1030424-71-5
1-[2-(Methoxymethyl)-3,7-diphenylpyrazolo[1,5-a]pyrimidin-6-yl]ethanone
CAS 1030424-71-5C22H19N3O2
7-(3-Methoxyphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H15N3O, CAS 1350991-30-8
7-(3-Methoxyphenyl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 1350991-30-8C19H15N3O