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Murcko scaffold

Ring system with 4 rings and 21 atoms

20 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 20
With full pages: 2

Scaffold SMILES

c1ccc(-n2ncc3c(N4CCOCC4)ncnc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(-n2ncc3c(N4CCOCC4)ncnc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

4-[1-(3-Methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine chemical structure, C16H17N5O, CAS 305337-36-4

4-[1-(3-Methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

CAS 305337-36-4C₁₆H₁₇N₅O

4-[1-(2,4-Dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine chemical structure, C17H19N5O, CAS 393845-14-2

4-[1-(2,4-Dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

CAS 393845-14-2C₁₇H₁₉N₅O

4-[1-(4-Methoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine chemical structure, C16H17N5O2, CAS 393845-13-1

4-[1-(4-Methoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

CAS 393845-13-1C₁₆H₁₇N₅O₂

6-(Methylsulfanyl)-4-morpholino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C16H17N5OS, CAS 478081-02-6

6-(Methylsulfanyl)-4-morpholino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

CAS 478081-02-6C₁₆H₁₇N₅OS

1-(4-Methylphenyl)-6-(methylsulfanyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5OS, CAS 478081-04-8

1-(4-Methylphenyl)-6-(methylsulfanyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidine

CAS 478081-04-8C₁₇H₁₉N₅OS

4-[1-(2,4-Dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-2,6-dimethylmorpholine chemical structure, C19H23N5O, CAS 393823-08-0

4-[1-(2,4-Dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-2,6-dimethylmorpholine

CAS 393823-08-0C₁₉H₂₃N₅O

2,6-Dimethyl-4-[1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine chemical structure, C18H21N5O, CAS 393821-29-9

2,6-Dimethyl-4-[1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

CAS 393821-29-9C₁₈H₂₁N₅O

4-[1-(4-Chlorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-2,6-dimethylmorpholine chemical structure, C17H18ClN5O, CAS 393822-20-3

4-[1-(4-Chlorophenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-2,6-dimethylmorpholine

CAS 393822-20-3C₁₇H₁₈ClN₅O

4-(2,6-Dimethylmorpholin-4-yl)-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C18H21N5O2, CAS 393822-76-9

4-(2,6-Dimethylmorpholin-4-yl)-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine

CAS 393822-76-9C₁₈H₂₁N₅O₂

4-(1-(3,4-Difluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine chemical structure, C15H13F2N5O, CAS 921162-81-4

4-(1-(3,4-Difluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

CAS 921162-81-4C₁₅H₁₃F₂N₅O

4-(1-(3,4-Dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine chemical structure, C15H13Cl2N5O, CAS 890897-89-9

4-(1-(3,4-Dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

CAS 890897-89-9C₁₅H₁₃Cl₂N₅O

1-(5-Chloro-2-methylphenyl)-4-(2,6-dimethylmorpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C18H20ClN5O, CAS 890938-08-6

1-(5-Chloro-2-methylphenyl)-4-(2,6-dimethylmorpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

CAS 890938-08-6C₁₈H₂₀ClN₅O

1-(3-Chlorophenyl)-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C15H14ClN5O, CAS 872623-05-7

1-(3-Chlorophenyl)-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

CAS 872623-05-7C₁₅H₁₄ClN₅O

1-(2,5-Dimethylphenyl)-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C17H19N5O, CAS 946304-24-1

1-(2,5-Dimethylphenyl)-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

CAS 946304-24-1C₁₇H₁₉N₅O

4-(1-(4-Chloro-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine chemical structure, C16H16ClN5O, CAS 946273-12-7

4-(1-(4-Chloro-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

CAS 946273-12-7C₁₆H₁₆ClN₅O

4-[1-(3,5-Dimethylphenyl)pyrazolo[4,5-e]pyrimidin-4-yl]morpholine chemical structure, C17H19N5O, CAS 955306-42-0

4-[1-(3,5-Dimethylphenyl)pyrazolo[4,5-e]pyrimidin-4-yl]morpholine

CAS 955306-42-0C₁₇H₁₉N₅O

4-[1-(4-Fluorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]morpholine chemical structure, C15H14FN5O, CAS 872622-58-7

4-[1-(4-Fluorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]morpholine

CAS 872622-58-7C₁₅H₁₄FN₅O

2,6-Dimethyl-4-(1-(o-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine chemical structure, C18H21N5O, CAS 1005308-05-3

2,6-Dimethyl-4-(1-(o-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

CAS 1005308-05-3C₁₈H₂₁N₅O

6-Chloro-4-morpholin-4-yl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C15H14ClN5O, CAS 58732-70-0

6-Chloro-4-morpholin-4-yl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

CAS 58732-70-0C₁₅H₁₄ClN₅O

1-(4-Fluorophenyl)-N-(1-methoxypropan-2-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-amine chemical structure, C19H23FN6O2, CAS 1207045-57-5

1-(4-Fluorophenyl)-N-(1-methoxypropan-2-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-amine

CAS 1207045-57-5C₁₉H₂₃FN₆O₂