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Murcko scaffold

Ring system with 4 rings and 21 atoms

33 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
33
With full pages
23
Scaffold SMILES

c1ccc(-c2cnn3c(N4CCOCC4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(N4CCOCC4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

4-(2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C18H20N4O, CAS 849924-34-1
4-(2,5-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 849924-34-1C18H20N4O
4-(2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C20H24N4O, CAS 896828-38-9
4-(2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 896828-38-9C20H24N4O
4-[5-tert-Butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]morpholine chemical structure, C20H23ClN4O, CAS 896831-40-6
4-[5-tert-Butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]morpholine
CAS 896831-40-6C20H23ClN4O
4-(3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C17H17ClN4O, CAS 896844-42-1
4-(3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 896844-42-1C17H17ClN4O
4-(5-(tert-Butyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C20H24N4O, CAS 896846-45-0
4-(5-(tert-Butyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 896846-45-0C20H24N4O
4-(5-Isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C20H24N4O, CAS 899415-41-9
4-(5-Isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 899415-41-9C20H24N4O
4-(3-(4-Chlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C18H19ClN4O, CAS 850193-71-4
4-(3-(4-Chlorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 850193-71-4C18H19ClN4O
4-[5-tert-Butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl]morpholine chemical structure, C21H25ClN4O, CAS 850800-25-8
4-[5-tert-Butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl]morpholine
CAS 850800-25-8C21H25ClN4O
4-(5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C17H18N4O, CAS 877794-58-6
4-(5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 877794-58-6C17H18N4O
4-(5-(tert-Butyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C21H26N4O, CAS 862194-17-0
4-(5-(tert-Butyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 862194-17-0C21H26N4O
4-[3-(4-Fluorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]morpholine chemical structure, C18H19FN4O, CAS 842111-86-8
4-[3-(4-Fluorophenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]morpholine
CAS 842111-86-8C18H19FN4O
3-(2-Methoxyphenyl)-2,5-dimethyl-7-morpholin-4-ylpyrazolo[1,5-a]pyrimidine chemical structure, C19H22N4O2, CAS 902020-78-4
3-(2-Methoxyphenyl)-2,5-dimethyl-7-morpholin-4-ylpyrazolo[1,5-a]pyrimidine
CAS 902020-78-4C19H22N4O2
4-(5-Isopropyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C19H22N4O, CAS 900263-12-9
4-(5-Isopropyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900263-12-9C19H22N4O
4-(2-Ethyl-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C19H22N4O, CAS 900270-14-6
4-(2-Ethyl-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900270-14-6C19H22N4O
3-(2-Methoxyphenyl)-5-methyl-7-(morpholin-4-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H20N4O2, CAS 902039-59-2
3-(2-Methoxyphenyl)-5-methyl-7-(morpholin-4-yl)pyrazolo[1,5-a]pyrimidine
CAS 902039-59-2C18H20N4O2
4-(5-(tert-Butyl)-3-(2-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C21H25ClN4O, CAS 902048-99-1
4-(5-(tert-Butyl)-3-(2-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 902048-99-1C21H25ClN4O
4-[5-tert-Butyl-3-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]morpholine chemical structure, C20H23ClN4O, CAS 902009-19-2
4-[5-tert-Butyl-3-(2-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]morpholine
CAS 902009-19-2C20H23ClN4O
4-(2,5-Dimethyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C19H22N4O, CAS 900896-19-7
4-(2,5-Dimethyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900896-19-7C19H22N4O
4-(5-Methyl-3-phenyl-6-prop-2-enylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C20H22N4O, CAS 900900-21-2
4-(5-Methyl-3-phenyl-6-prop-2-enylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900900-21-2C20H22N4O
4-(3-(3,4-Dimethoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C20H24N4O3, CAS 900884-62-0
4-(3-(3,4-Dimethoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900884-62-0C20H24N4O3
4-(5-Methyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C18H20N4O, CAS 900869-56-9
4-(5-Methyl-3-(p-tolyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 900869-56-9C18H20N4O
4-(5-Methyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C18H17F3N4O, CAS 902023-31-8
4-(5-Methyl-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 902023-31-8C18H17F3N4O
3-(2-Chlorophenyl)-5-methyl-7-(morpholin-4-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C17H17ClN4O, CAS 902023-61-4
3-(2-Chlorophenyl)-5-methyl-7-(morpholin-4-yl)pyrazolo[1,5-a]pyrimidine
CAS 902023-61-4C17H17ClN4O
4-(5,6-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine chemical structure, C18H20N4O, CAS 879470-55-0
4-(5,6-Dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)morpholine
CAS 879470-55-0C18H20N4O