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Murcko scaffold

Ring system with 4 rings and 21 atoms

123 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
123
With full pages
3
Scaffold SMILES

c1ccc(-c2cnn3c(N4CCNCC4)ccnc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnn3c(N4CCNCC4)ccnc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 123 chemicals

3-(4-Chlorophenyl)-7-(4-ethylpiperazin-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C20H24ClN5, CAS 849916-86-5
3-(4-Chlorophenyl)-7-(4-ethylpiperazin-1-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine
CAS 849916-86-5C20H24ClN5
5-(tert-Butyl)-7-(4-(2-methylallyl)piperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C24H31N5, CAS 896817-61-1
5-(tert-Butyl)-7-(4-(2-methylallyl)piperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896817-61-1C24H31N5
2-(4-(3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanol chemical structure, C19H22ClN5O, CAS 896835-03-3
2-(4-(3-(4-Chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)ethanol
CAS 896835-03-3C19H22ClN5O
2-{4-[5-tert-Butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl}ethanol chemical structure, C22H28ClN5O, CAS 896836-68-3
2-{4-[5-tert-Butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]piperazin-1-yl}ethanol
CAS 896836-68-3C22H28ClN5O
5-(tert-Butyl)-7-(4-ethylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C22H29N5, CAS 896843-82-6
5-(tert-Butyl)-7-(4-ethylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896843-82-6C22H29N5
5-Methyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C18H21N5, CAS 850188-72-6
5-Methyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850188-72-6C18H21N5
2-[4-(2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol chemical structure, C22H29N5O, CAS 896853-91-1
2-[4-(2-Methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol
CAS 896853-91-1C22H29N5O
7-(4-Ethylpiperazin-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C22H29N5, CAS 899410-01-6
7-(4-Ethylpiperazin-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 899410-01-6C22H29N5
5-Isopropyl-2-methyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H27N5, CAS 899393-38-5
5-Isopropyl-2-methyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 899393-38-5C21H27N5
2-[4-(5-tert-Butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol chemical structure, C23H31N5O, CAS 850193-51-0
2-[4-(5-tert-Butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol
CAS 850193-51-0C23H31N5O
3-(4-Chlorophenyl)-5-methyl-7-(4-(2-methylallyl)piperazin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H24ClN5, CAS 899401-02-6
3-(4-Chlorophenyl)-5-methyl-7-(4-(2-methylallyl)piperazin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 899401-02-6C21H24ClN5
5-(tert-Butyl)-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C21H27N5, CAS 899388-83-1
5-(tert-Butyl)-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 899388-83-1C21H27N5
7-(4-Ethylpiperazin-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C20H25N5, CAS 850229-05-9
7-(4-Ethylpiperazin-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850229-05-9C20H25N5
7-(4-Ethylpiperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H23N5, CAS 850229-88-8
7-(4-Ethylpiperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850229-88-8C19H23N5
2-[4-(5-tert-Butyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol chemical structure, C22H29N5O, CAS 899393-43-2
2-[4-(5-tert-Butyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol
CAS 899393-43-2C22H29N5O
3-(4-Chlorophenyl)-7-(4-ethylpiperazin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C19H22ClN5, CAS 899406-66-7
3-(4-Chlorophenyl)-7-(4-ethylpiperazin-1-yl)-5-methylpyrazolo[1,5-a]pyrimidine
CAS 899406-66-7C19H22ClN5
2-Methyl-7-(4-methylpiperazin-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C21H27N5, CAS 899406-69-0
2-Methyl-7-(4-methylpiperazin-1-yl)-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 899406-69-0C21H27N5
7-(4-Ethylpiperazin-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C22H29N5, CAS 900264-51-9
7-(4-Ethylpiperazin-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 900264-51-9C22H29N5
3-(4-Chlorophenyl)-5-methyl-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C18H20ClN5, CAS 900271-38-7
3-(4-Chlorophenyl)-5-methyl-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 900271-38-7C18H20ClN5
2-[4-(5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol chemical structure, C19H23N5O, CAS 850236-62-3
2-[4-(5-Methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol
CAS 850236-62-3C19H23N5O
2,5-Dimethyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C19H23N5, CAS 850241-95-1
2,5-Dimethyl-7-(4-methylpiperazin-1-yl)-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850241-95-1C19H23N5
5-tert-Butyl-3-(4-chlorophenyl)-2-methyl-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C22H28ClN5, CAS 850744-85-3
5-tert-Butyl-3-(4-chlorophenyl)-2-methyl-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 850744-85-3C22H28ClN5
5-tert-Butyl-3-(4-chlorophenyl)-7-(4-ethylpiperazin-1-yl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C23H30ClN5, CAS 850824-86-1
5-tert-Butyl-3-(4-chlorophenyl)-7-(4-ethylpiperazin-1-yl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 850824-86-1C23H30ClN5
5-tert-Butyl-3-(4-chlorophenyl)-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C21H26ClN5, CAS 896065-50-2
5-tert-Butyl-3-(4-chlorophenyl)-7-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidine
CAS 896065-50-2C21H26ClN5