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Murcko scaffold

Ring system with 4 rings and 21 atoms

73 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 73
With full pages: 28

Scaffold SMILES

C1=CC(c2ccccc2)c2cnn(-c3ccccc3)c2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C1=CC(c2ccccc2)c2cnn(-c3ccccc3)c2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 73 chemicals

6-Amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano(2,3-c)pyrazole-5-carbonitrile chemical structure, C20H16N4O, CAS 53316-57-7

6-Amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano(2,3-c)pyrazole-5-carbonitrile

CAS 53316-57-7C₂₀H₁₆N₄O

6-Amino-1,4-dihydro-4-(4-methoxyphenyl)-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O2, CAS 53316-60-2

6-Amino-1,4-dihydro-4-(4-methoxyphenyl)-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

CAS 53316-60-2C₂₁H₁₈N₄O₂

RefChem:357115 chemical structure, C20H15N5O3, CAS 76973-34-7

CAS 76973-34-7C₂₀H₁₅N₅O₃

6-Amino-4-(4-chlorophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15ClN4O, CAS 76973-35-8

6-Amino-4-(4-chlorophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

CAS 76973-35-8C₂₀H₁₅ClN₄O

6-Amino-4-(2,3-dimethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C22H20N4O3, CAS 331862-15-8

6-Amino-4-(2,3-dimethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile

CAS 331862-15-8C₂₂H₂₀N₄O₃

6-Amino-4-(4-bromophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15BrN4O, CAS 82805-69-4

6-Amino-4-(4-bromophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 82805-69-4C₂₀H₁₅BrN₄O

6-Amino-4-(4-fluorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15FN4O, CAS 82805-68-3

6-Amino-4-(4-fluorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 82805-68-3C₂₀H₁₅FN₄O

6-Amino-4-(2,4-dichlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H14Cl2N4O, CAS 307553-10-2

6-Amino-4-(2,4-dichlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 307553-10-2C₂₀H₁₄Cl₂N₄O

6-Amino-3-methyl-4-(2-nitrophenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15N5O3, CAS 300804-47-1

6-Amino-3-methyl-4-(2-nitrophenyl)-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 300804-47-1C₂₀H₁₅N₅O₃

6-Amino-1,4-dihydro-3-methyl-4-(3-nitrophenyl)-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15N5O3, CAS 81000-14-8

6-Amino-1,4-dihydro-3-methyl-4-(3-nitrophenyl)-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

CAS 81000-14-8C₂₀H₁₅N₅O₃

6-Amino-4-(3-hydroxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H16N4O2, CAS 5224-71-5

6-Amino-4-(3-hydroxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 5224-71-5C₂₀H₁₆N₄O₂

6-Amino-4-(4-hydroxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H16N4O2, CAS 330957-86-3

6-Amino-4-(4-hydroxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 330957-86-3C₂₀H₁₆N₄O₂

6-Amino-4-(3,4-dimethoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C22H20N4O3, CAS 5224-72-6

6-Amino-4-(3,4-dimethoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 5224-72-6C₂₂H₂₀N₄O₃

6-Amino-3-methyl-1-phenyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C23H22N4O4, CAS 170030-57-6

6-Amino-3-methyl-1-phenyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 170030-57-6C₂₃H₂₂N₄O₄

6-Amino-3-methyl-1-phenyl-4-(p-tolyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O, CAS 53316-59-9

6-Amino-3-methyl-1-phenyl-4-(p-tolyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 53316-59-9C₂₁H₁₈N₄O

6-Amino-4-(2-chlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15ClN4O, CAS 82805-70-7

6-Amino-4-(2-chlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 82805-70-7C₂₀H₁₅ClN₄O

6-Amino-4-(4-ethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C22H20N4O2, CAS 312265-18-2

6-Amino-4-(4-ethoxyphenyl)-3-methyl-1-phenyl-4H-pyrano[2,3-c]pyrazole-5-carbonitrile

CAS 312265-18-2C₂₂H₂₀N₄O₂

6-Amino-4-(3-chlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15ClN4O, CAS 293329-86-9

6-Amino-4-(3-chlorophenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 293329-86-9C₂₀H₁₅ClN₄O

6-Amino-4-(2,5-diethoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C24H24N4O3, CAS 329693-18-7

6-Amino-4-(2,5-diethoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 329693-18-7C₂₄H₂₄N₄O₃

6-Amino-4-(2-chloro-6-fluorophenyl)-1-phenyl-3-(trifluoromethyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H11ClF4N4O, CAS 294878-10-7

6-Amino-4-(2-chloro-6-fluorophenyl)-1-phenyl-3-(trifluoromethyl)-4H-pyrano[2,3-c]pyrazole-5-carbonitrile

CAS 294878-10-7C₂₀H₁₁ClF₄N₄O

Methyl 4-(6-amino-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)benzoate chemical structure, C22H18N4O3, CAS 313702-97-5

Methyl 4-(6-amino-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)benzoate

CAS 313702-97-5C₂₂H₁₈N₄O₃

6-Amino-4-(3,4-dimethoxyphenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C23H22N4O3, CAS 309278-34-0

6-Amino-4-(3,4-dimethoxyphenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 309278-34-0C₂₃H₂₂N₄O₃

6-Amino-4-(2-chloro-6-fluorophenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H16ClFN4O, CAS 305862-70-8

6-Amino-4-(2-chloro-6-fluorophenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 305862-70-8C₂₁H₁₆ClFN₄O

6-Amino-4-(2-fluorophenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H17FN4O, CAS 309278-39-5

6-Amino-4-(2-fluorophenyl)-3-methyl-1-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 309278-39-5C₂₁H₁₇FN₄O